Thrombin induces suppressor of cytokine signaling 3 expression in brain microglia via protein kinase Cdelta activation

Microglia (brain macrophages) are activated upon brain damage. In this study, we demonstrated that thrombin, a pro-inflammatory stimulator of microglia, induced expression of suppressors of cytokine signaling (SOCS) in microglia. RT-PCR analysis and Northern blot analysis showed that thrombin induce...

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Veröffentlicht in:	Biochemical and biophysical research communications 2004-05, Vol.317 (3), p.811-816
Hauptverfasser:	Yang, Myung-Soon, Lee, Jeehyung, Ji, Kyung-Ae, Min, Kyoung-jin, Lee, Myung Ae, Jou, Ilo, Joe, Eunhye
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Blotting, Northern Brain - enzymology DNA Primers Enzyme Activation Microglia - enzymology Microglia - metabolism Protein Kinase C - metabolism Protein Kinase C-delta Repressor Proteins - genetics RNA, Messenger - genetics Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Thrombin - physiology Transcription Factors - genetics
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