Modulation of error-prone double-strand break repair in mammalian chromosomes by DNA mismatch repair protein Mlh1

We assayed error-prone double-strand break (DSB) repair in wild-type and isogenic Mlh1-null mouse embryonic fibroblasts containing a stably integrated DSB repair substrate. The substrate contained a thymidine kinase ( tk) gene fused to a neomycin-resistance ( neo) gene; the tk-neo fusion gene was di...

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Veröffentlicht in:	DNA repair 2004-05, Vol.3 (5), p.465-474
Hauptverfasser:	Bannister, Laura A., Waldman, Barbara Criscuolo, Waldman, Alan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Base Pair Mismatch - genetics Base Sequence Carrier Proteins Cell Line Chromosome Breakage - genetics Chromosomes, Mammalian - genetics Chromosomes, Mammalian - metabolism DNA mismatch repair DNA Repair Double-strand break repair Endonuclease I- SceI Gene Deletion Mice Mice, Knockout MutL Protein Homolog 1 Neoplasm Proteins - deficiency Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nonhomologous end-joining Nuclear Proteins
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