The Von Willebrand Factor Propeptide (VWFpp) Traffics an Unrelated Protein to Storage

The von Willebrand factor (VWF) propeptide (VWFpp) is critical for the targeting of VWF multimers to storage granules. VWFpp alone efficiently navigates the storage pathway in AtT-20 and endothelial cells and chaperones mature VWF multimers to storage granules when the two proteins are expressed in...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2002-06, Vol.22 (6), p.921-926
Hauptverfasser:	Haberichter, Sandra L, Jozwiak, Mary A, Rosenberg, Jonathan B, Christopherson, Pamela A, Montgomery, Robert R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - cytology Aorta - metabolism Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cattle Cell Line Complement C3a - biosynthesis Complement C3a - genetics Complement C3a - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Medical sciences Mice Peptides - genetics Peptides - metabolism Peptides - physiology Protein Precursors - biosynthesis Protein Precursors - genetics Protein Precursors - metabolism Protein Precursors - physiology Protein Sorting Signals - genetics Protein Sorting Signals - physiology Protein Transport - physiology Proteins - metabolism Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Secretory Vesicles - metabolism von Willebrand Factor - biosynthesis von Willebrand Factor - genetics von Willebrand Factor - metabolism von Willebrand Factor - physiology Weibel-Palade Bodies - metabolism
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