The role of ribose in human skeletal muscle metabolism
Bioenergetic pathways in muscle provide high-energy compounds that are required for cellular integrity and function. Increased cellular demand for adenosine triphosphate (ATP) or limitations in the rephosphorylation rate of adenosine diphosphate (ADP) can decrease the total adenine nucleotide (TAN)...
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| Veröffentlicht in: | Medical hypotheses 2004-01, Vol.62 (5), p.819-824 |
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| creator | Dodd, Stephen L Johnson, Clarence A Fernholz, Kelijo Cyr, John A.St |
| description | Bioenergetic pathways in muscle provide high-energy compounds that are required for cellular integrity and function. Increased cellular demand for adenosine triphosphate (ATP) or limitations in the rephosphorylation rate of adenosine diphosphate (ADP) can decrease the total adenine nucleotide (TAN) pool, which may take several days to recover or may not recover at all in cases of chronic ischemia. Total adenine nucleotide levels may be significantly decreased as a result of myocardial or skeletal muscle ischemia, certain metabolic diseases, repeated intense skeletal muscle contractions or in repetitive high-intensity exercise. Ribose, a naturally occurring pentose sugar, has been shown to enhance the recovery of myocardial or skeletal muscle ATP and TAN levels following ischemia or high-intensity exercise. Furthermore, ribose has been demonstrated to modulate the production of oxygen free radicals during and following exercise. The following paper reviews skeletal muscle energetics and the potential role of ribose during and following exercise. |
| doi_str_mv | 10.1016/j.mehy.2003.10.026 |
| format | Article |
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Increased cellular demand for adenosine triphosphate (ATP) or limitations in the rephosphorylation rate of adenosine diphosphate (ADP) can decrease the total adenine nucleotide (TAN) pool, which may take several days to recover or may not recover at all in cases of chronic ischemia. Total adenine nucleotide levels may be significantly decreased as a result of myocardial or skeletal muscle ischemia, certain metabolic diseases, repeated intense skeletal muscle contractions or in repetitive high-intensity exercise. Ribose, a naturally occurring pentose sugar, has been shown to enhance the recovery of myocardial or skeletal muscle ATP and TAN levels following ischemia or high-intensity exercise. Furthermore, ribose has been demonstrated to modulate the production of oxygen free radicals during and following exercise. 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The following paper reviews skeletal muscle energetics and the potential role of ribose during and following exercise.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Exercise - physiology</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle, Skeletal - physiology</subject><subject>Physical Endurance - physiology</subject><subject>Physical Exertion - physiology</subject><subject>Ribose - metabolism</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6BzxIT95aJ0mbNOBFxC9Y8LL3kKRTNms_1qQV9t_bsgvePA0zPO8L8xBySyGjQMXDLmtxe8gYAJ8OGTBxRpa04CxlUspzsgQOIlWllAtyFeMOAFTOy0uyoAWUjNJ8ScRmi0noG0z6Ogne9hET3yXbsTVdEr-wwcE0STtGNyHttNi-8bG9Jhe1aSLenOaKbF5fNs_v6frz7eP5aZ06XrAhLSoLlWLCKllZywspcrS8yotSFLQEVyqFEqi0tLbSqNoiGHAGBFrDheIrcn-s3Yf-e8Q46NZHh01jOuzHqCUtmchzNoHsCLrQxxiw1vvgWxMOmoKeZemdnmXpWdZ8m2RNobtT-2hbrP4iJzsT8HgEcHrxx2PQ0XnsHFY-oBt01fv_-n8B2rh6Vg</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Dodd, Stephen L</creator><creator>Johnson, Clarence A</creator><creator>Fernholz, Kelijo</creator><creator>Cyr, John A.St</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>The role of ribose in human skeletal muscle metabolism</title><author>Dodd, Stephen L ; Johnson, Clarence A ; Fernholz, Kelijo ; Cyr, John A.St</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-5db0d926b97dbb35764eb3d45865180c899e7017b1fb7a9fbe0a0ca06eba3693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Exercise - physiology</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle, Skeletal - physiology</topic><topic>Physical Endurance - physiology</topic><topic>Physical Exertion - physiology</topic><topic>Ribose - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dodd, Stephen L</creatorcontrib><creatorcontrib>Johnson, Clarence A</creatorcontrib><creatorcontrib>Fernholz, Kelijo</creatorcontrib><creatorcontrib>Cyr, John A.St</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical hypotheses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dodd, Stephen L</au><au>Johnson, Clarence A</au><au>Fernholz, Kelijo</au><au>Cyr, John A.St</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of ribose in human skeletal muscle metabolism</atitle><jtitle>Medical hypotheses</jtitle><addtitle>Med Hypotheses</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>62</volume><issue>5</issue><spage>819</spage><epage>824</epage><pages>819-824</pages><issn>0306-9877</issn><eissn>1532-2777</eissn><abstract>Bioenergetic pathways in muscle provide high-energy compounds that are required for cellular integrity and function. 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| fulltext | fulltext |
| identifier | ISSN: 0306-9877 |
| ispartof | Medical hypotheses, 2004-01, Vol.62 (5), p.819-824 |
| issn | 0306-9877 1532-2777 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adenosine Triphosphate - metabolism Exercise - physiology Humans Models, Biological Muscle Contraction - physiology Muscle, Skeletal - physiology Physical Endurance - physiology Physical Exertion - physiology Ribose - metabolism |
| title | The role of ribose in human skeletal muscle metabolism |
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