Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress

‘Tissue’ transglutaminase (tTG) selectively accumulates in cells undergoing apoptosis both in vivo and in vitro. Considering the central role played by mitochondria in apoptosis, we investigated the relationships existing amongst tTG expression, apoptosis and mitochondrial function. To this aim we s...

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Veröffentlicht in:	Journal of neurochemistry 2002-06, Vol.81 (5), p.1061-1072
Hauptverfasser:	Grazia Farrace, Maria, Piredda, Lucia, Matarrese, Paola, Ciccosanti, Fabiola, Falasca, Laura, Rodolfo, Carlo, Giammarioli, Anna Maria, Verderio, Elisabetta, Griffin, Martin, Malorni, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Ageing, cell death Animals apoptosis Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Cell physiology Child Cyclosporine - pharmacology Enzyme Inhibitors - pharmacology Flow Cytometry Fundamental and applied biological sciences. Psychology Gene Expression GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism GTP-Binding Proteins - pharmacology Humans Intracellular Membranes - physiology Ion Channels - metabolism Membrane Potentials - drug effects Membrane Potentials - physiology Mice Mitochondria - drug effects Mitochondria - metabolism Mitochondria - ultrastructure mitochondrial membrane potential Mitochondrial Membrane Transport Proteins Molecular and cellular biology Neuroblastoma - metabolism Neurons - drug effects Neurons - metabolism Neurons - ultrastructure Oxidation-Reduction - drug effects Oxidative Stress - drug effects Oxidative Stress - physiology Tetracycline - pharmacology Transfection transglutaminase Transglutaminases - genetics Transglutaminases - metabolism Transglutaminases - pharmacology Tumor Cells, Cultured
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