Human thyroid carcinoma cell lines show different retinoic acid receptor repertoires and retinoid responses

OBJECTIVE: Disturbed expression of retinoic acid (RA) receptors (RAR/RXR) contributes to the pathogenesis and tumor progression of epithelial carcinomas. DESIGN: To examine whether altered responses to retinoids may correlate with differences in RA receptor equipment, retinoid effects were examined...

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Veröffentlicht in:	European journal of endocrinology 2004-04, Vol.150 (4), p.547-556
Hauptverfasser:	Schmutzler, C, Hoang-Vu, C, Ruger, B, Kohrle, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Follicular - drug therapy Adenocarcinoma, Follicular - physiopathology Animals Antineoplastic Agents - pharmacology Biological and medical sciences Cell Line, Tumor Endocrinopathies Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic - drug effects Humans Medical sciences Mice Mice, Nude Non tumoral diseases. Target tissue resistance. Benign neoplasms Rats Rats, Nude Receptors, Retinoic Acid - genetics Retinoic Acid Receptor alpha RNA, Messenger - analysis Thyroid Neoplasms - drug therapy Thyroid Neoplasms - physiopathology Thyroid. Thyroid axis (diseases) Tretinoin - pharmacology Vertebrates: endocrinology Xenograft Model Antitumor Assays
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