Expression of the neonatal Fc receptor (FcRn) at the blood–brain barrier
The blood–brain barrier (BBB) restricts transport of immunoglobulin G (IgG) in the blood to brain direction. However, IgG undergoes rapid efflux in the brain to blood direction via reverse transcytosis across the BBB after direct intracerebral injection. This BBB IgG transport system has the charact...
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| Veröffentlicht in: | Journal of neurochemistry 2002-04, Vol.81 (1), p.203-206 |
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| creator | Schlachetzki, Felix Zhu, Chunni Pardridge, William M. |
| description | The blood–brain barrier (BBB) restricts transport of immunoglobulin G (IgG) in the blood to brain direction. However, IgG undergoes rapid efflux in the brain to blood direction via reverse transcytosis across the BBB after direct intracerebral injection. This BBB IgG transport system has the characteristics of an Fc receptor (FcR), but there is no molecular information on the putative BBB FcR. The present study uses confocal microscopy and an antibody to the rat neonatal FcR (FcRn), and demonstrates the expression of the FcRn at the brain microvasculature and choroid plexus epithelium. Co‐localization with the Glut1 glucose transporter indicates the brain microvascular FcRn is expressed in the capillary endothelium. The capillary endothelial FcRn may mediate the ‘reverse transcytosis’ of IgG in the brain to blood direction. |
| doi_str_mv | 10.1046/j.1471-4159.2002.00840.x |
| format | Article |
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However, IgG undergoes rapid efflux in the brain to blood direction via reverse transcytosis across the BBB after direct intracerebral injection. This BBB IgG transport system has the characteristics of an Fc receptor (FcR), but there is no molecular information on the putative BBB FcR. The present study uses confocal microscopy and an antibody to the rat neonatal FcR (FcRn), and demonstrates the expression of the FcRn at the brain microvasculature and choroid plexus epithelium. Co‐localization with the Glut1 glucose transporter indicates the brain microvascular FcRn is expressed in the capillary endothelium. The capillary endothelial FcRn may mediate the ‘reverse transcytosis’ of IgG in the brain to blood direction.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1046/j.1471-4159.2002.00840.x</identifier><identifier>PMID: 12067234</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science, Ltd</publisher><subject>Animals ; Arterioles - cytology ; Arterioles - metabolism ; Biological and medical sciences ; biological transport ; Blood-Brain Barrier - physiology ; blood–brain barrier ; Brain - cytology ; Brain - metabolism ; Capillaries - cytology ; Capillaries - metabolism ; Cell Line ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Choroid Plexus - cytology ; Choroid Plexus - metabolism ; endothelium ; Endothelium, Vascular - cytology ; Endothelium, Vascular - metabolism ; Fundamental and applied biological sciences. Psychology ; Glucose Transporter Type 1 ; Histocompatibility Antigens Class I ; Kidney - cytology ; Kidney - metabolism ; Liver - cytology ; Liver - metabolism ; Male ; Mice ; Microcirculation ; Microscopy, Confocal ; Monosaccharide Transport Proteins - biosynthesis ; Muscle, Skeletal - cytology ; Muscle, Skeletal - innervation ; Muscle, Skeletal - metabolism ; neonatal Fc receptor ; Organ Specificity ; Rats ; Receptors, Fc - biosynthesis ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of neurochemistry, 2002-04, Vol.81 (1), p.203-206</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4920-cf9564f74426959fdfdbddf0cb35a5d1cc4d8c4f07a0bc8cc42078ef4310df333</citedby><cites>FETCH-LOGICAL-c4920-cf9564f74426959fdfdbddf0cb35a5d1cc4d8c4f07a0bc8cc42078ef4310df333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1471-4159.2002.00840.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1471-4159.2002.00840.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13609828$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12067234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schlachetzki, Felix</creatorcontrib><creatorcontrib>Zhu, Chunni</creatorcontrib><creatorcontrib>Pardridge, William M.</creatorcontrib><title>Expression of the neonatal Fc receptor (FcRn) at the blood–brain barrier</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>The blood–brain barrier (BBB) restricts transport of immunoglobulin G (IgG) in the blood to brain direction. However, IgG undergoes rapid efflux in the brain to blood direction via reverse transcytosis across the BBB after direct intracerebral injection. This BBB IgG transport system has the characteristics of an Fc receptor (FcR), but there is no molecular information on the putative BBB FcR. The present study uses confocal microscopy and an antibody to the rat neonatal FcR (FcRn), and demonstrates the expression of the FcRn at the brain microvasculature and choroid plexus epithelium. Co‐localization with the Glut1 glucose transporter indicates the brain microvascular FcRn is expressed in the capillary endothelium. The capillary endothelial FcRn may mediate the ‘reverse transcytosis’ of IgG in the brain to blood direction.</description><subject>Animals</subject><subject>Arterioles - cytology</subject><subject>Arterioles - metabolism</subject><subject>Biological and medical sciences</subject><subject>biological transport</subject><subject>Blood-Brain Barrier - physiology</subject><subject>blood–brain barrier</subject><subject>Brain - cytology</subject><subject>Brain - metabolism</subject><subject>Capillaries - cytology</subject><subject>Capillaries - metabolism</subject><subject>Cell Line</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Choroid Plexus - cytology</subject><subject>Choroid Plexus - metabolism</subject><subject>endothelium</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose Transporter Type 1</subject><subject>Histocompatibility Antigens Class I</subject><subject>Kidney - cytology</subject><subject>Kidney - metabolism</subject><subject>Liver - cytology</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Microcirculation</subject><subject>Microscopy, Confocal</subject><subject>Monosaccharide Transport Proteins - biosynthesis</subject><subject>Muscle, Skeletal - cytology</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - metabolism</subject><subject>neonatal Fc receptor</subject><subject>Organ Specificity</subject><subject>Rats</subject><subject>Receptors, Fc - biosynthesis</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1O20AQgFdVUQkpr1DtpRUc7M7uju31gQOKSAtCRULlvFrvj-rIsdNdRyS3vgNv2CfBJhE5wmlmNN_86COEMkgZYP59kTIsWIIsK1MOwFMAiZBuPpDJa-MjmQwdnghAfkxOYlwAsBxz9okcMw55wQVOyM3VZhVcjHXX0s7T_o-jreta3euGzg0NzrhV3wV6Njf37TnV_QtSNV1n__97qoKuW1rpEGoXPpMjr5voTvdxSh7mV79nP5Pbux_Xs8vbxGDJITG-zHL0BSLPy6z01tvKWg-mEpnOLDMGrTToodBQGTmUHArpPAoG1gshpuTbbu8qdH_XLvZqWUfjmkYPn6-jKpjkyBHfBJlEVrKyGEC5A03oYgzOq1WolzpsFQM1ClcLNXpVo1c1ClcvwtVmGP2yv7Guls4eBveGB-DrHtDR6MYH3Zo6HjiRQym5HLiLHfdYN2777gfUza_ZmIlns82bsw</recordid><startdate>200204</startdate><enddate>200204</enddate><creator>Schlachetzki, Felix</creator><creator>Zhu, Chunni</creator><creator>Pardridge, William M.</creator><general>Blackwell Science, Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200204</creationdate><title>Expression of the neonatal Fc receptor (FcRn) at the blood–brain barrier</title><author>Schlachetzki, Felix ; Zhu, Chunni ; Pardridge, William M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4920-cf9564f74426959fdfdbddf0cb35a5d1cc4d8c4f07a0bc8cc42078ef4310df333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Arterioles - cytology</topic><topic>Arterioles - metabolism</topic><topic>Biological and medical sciences</topic><topic>biological transport</topic><topic>Blood-Brain Barrier - physiology</topic><topic>blood–brain barrier</topic><topic>Brain - cytology</topic><topic>Brain - metabolism</topic><topic>Capillaries - cytology</topic><topic>Capillaries - metabolism</topic><topic>Cell Line</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Choroid Plexus - cytology</topic><topic>Choroid Plexus - metabolism</topic><topic>endothelium</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose Transporter Type 1</topic><topic>Histocompatibility Antigens Class I</topic><topic>Kidney - cytology</topic><topic>Kidney - metabolism</topic><topic>Liver - cytology</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Microcirculation</topic><topic>Microscopy, Confocal</topic><topic>Monosaccharide Transport Proteins - biosynthesis</topic><topic>Muscle, Skeletal - cytology</topic><topic>Muscle, Skeletal - innervation</topic><topic>Muscle, Skeletal - metabolism</topic><topic>neonatal Fc receptor</topic><topic>Organ Specificity</topic><topic>Rats</topic><topic>Receptors, Fc - biosynthesis</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schlachetzki, Felix</creatorcontrib><creatorcontrib>Zhu, Chunni</creatorcontrib><creatorcontrib>Pardridge, William M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schlachetzki, Felix</au><au>Zhu, Chunni</au><au>Pardridge, William M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of the neonatal Fc receptor (FcRn) at the blood–brain barrier</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>2002-04</date><risdate>2002</risdate><volume>81</volume><issue>1</issue><spage>203</spage><epage>206</epage><pages>203-206</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>The blood–brain barrier (BBB) restricts transport of immunoglobulin G (IgG) in the blood to brain direction. However, IgG undergoes rapid efflux in the brain to blood direction via reverse transcytosis across the BBB after direct intracerebral injection. This BBB IgG transport system has the characteristics of an Fc receptor (FcR), but there is no molecular information on the putative BBB FcR. The present study uses confocal microscopy and an antibody to the rat neonatal FcR (FcRn), and demonstrates the expression of the FcRn at the brain microvasculature and choroid plexus epithelium. Co‐localization with the Glut1 glucose transporter indicates the brain microvascular FcRn is expressed in the capillary endothelium. The capillary endothelial FcRn may mediate the ‘reverse transcytosis’ of IgG in the brain to blood direction.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science, Ltd</pub><pmid>12067234</pmid><doi>10.1046/j.1471-4159.2002.00840.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Arterioles - cytology Arterioles - metabolism Biological and medical sciences biological transport Blood-Brain Barrier - physiology blood–brain barrier Brain - cytology Brain - metabolism Capillaries - cytology Capillaries - metabolism Cell Line Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Choroid Plexus - cytology Choroid Plexus - metabolism endothelium Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fundamental and applied biological sciences. Psychology Glucose Transporter Type 1 Histocompatibility Antigens Class I Kidney - cytology Kidney - metabolism Liver - cytology Liver - metabolism Male Mice Microcirculation Microscopy, Confocal Monosaccharide Transport Proteins - biosynthesis Muscle, Skeletal - cytology Muscle, Skeletal - innervation Muscle, Skeletal - metabolism neonatal Fc receptor Organ Specificity Rats Receptors, Fc - biosynthesis Vertebrates: nervous system and sense organs |
| title | Expression of the neonatal Fc receptor (FcRn) at the blood–brain barrier |
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