Post-Ischemic Cardioprotection by A2A Adenosine Receptors: Dependent of Phosphatidylinositol 3-Kinase Pathway

Activation of myocardial A2A adenosine receptors during reperfusion has been shown to be cardioprotective. The intracellular mechanisms underlying this protection remain unknown. To understand the beneficial effects of activated A2A adenosine receptors in such a state, we investigated whether the en...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2004-03, Vol.43 (3), p.416-422
Hauptverfasser:	Boucher, Matthieu, Pesant, Stéphanie, Falcao, Stéphanie, de Montigny, Chantal, Schampaert, Érick, Cardinal, René, Rousseau, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine A2 Receptor Agonists Animals Blood Pressure - drug effects Caspase 3 Caspases - metabolism Chromones - pharmacology Enzyme Inhibitors - pharmacology Morpholines - pharmacology Myocardial Infarction - therapy Myocardial Reperfusion Injury - prevention & control Phenethylamines - pharmacology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Rabbits Receptor, Adenosine A2A - physiology Signal Transduction - drug effects
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