The tumor microenvironment: CXCR4 is associated with distinct protein expression patterns in neuroblastoma cells

In previous studies, we demonstrated that human neuroblastoma cells are equipped with the machinery to direct their homing to bone marrow. These tumor cells express the CXCR4 receptor for the bone marrow stroma-derived chemokine CXCL12 (SDF-1) and secrete the CXCL12 ligand. The present study was und...

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Veröffentlicht in:	Immunology letters 2004-03, Vol.92 (1), p.163-169
Hauptverfasser:	Nevo, Ido, Sagi-Assif, Orit, Meshel, Tsipi, Geminder, Hila, Goldberg-Bittman, Lilach, Ben-Menachem, Shlomit, Shalmon, Bruria, Goldberg, Iris, Ben-Baruch, Adit, Witz, Isaac P.
Format:	Artikel
Sprache:	eng
Schlagworte:	CD56 Antigen - immunology Chemokine CXCL12 Chemokines, CXC - immunology Chemokines, CXC - metabolism CXCL12-SDF-1α CXCR4 Cytokines - immunology Cytokines - metabolism Gene expression Gene Expression - immunology Gene Expression - physiology Gene Expression Profiling Humans Integrins - immunology Integrins - metabolism Neuroblastoma Neuroblastoma - immunology Proto-Oncogene Proteins c-kit - immunology Proto-Oncogene Proteins c-kit - metabolism Receptors, CXCR4 - immunology Synaptophysin - immunology Synaptophysin - metabolism
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