Attenuation of the amphetamine discriminative cue in rats with the atypical antipsychotic olanzapine

Sixteen male Sprague–Dawley rats were trained to discriminate between saline and amphetamine injections (1.0 mg/kg ip) using a standard two-lever (FR10) drug discrimination paradigm. A baseline dose–effect curve was generated for amphetamine administration alone, using doses both above and below the...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2002-07, Vol.72 (4), p.767-777
Hauptverfasser:	Mechanic, Jordan A, Wasielewski, Jill A, Carl, Kathy L, Holloway, Frank A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine Amphetamine - antagonists & inhibitors Amphetamine - pharmacology Animals Antipsychotic Agents - pharmacology Atypical antipsychotic Benzodiazepines Biological and medical sciences Central Nervous System Stimulants - antagonists & inhibitors Central Nervous System Stimulants - pharmacology Conditioning, Operant - drug effects Cues Discrimination (Psychology) - drug effects Dose-Response Relationship, Drug Drug addictions Drug discrimination Male Medical sciences Olanzapine Pirenzepine - analogs & derivatives Pirenzepine - pharmacology Rats Rats, Sprague-Dawley Rats, Wistar Reinforcement Schedule Stimulant abuse Toxicology
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