N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome
Objective: To evaluate the effect of N-acetyl-cysteine (NAC) on insulin secretion and peripheral insulin resistance in subjects with polycystic ovary syndrome (PCOS). Design: Prospective data analysis. Setting: Volunteer women in an academic research environment. Patient(s): Six lean and 31 obese su...
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| Veröffentlicht in: | Fertility and sterility 2002-06, Vol.77 (6), p.1128-1135 |
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| container_title | Fertility and sterility |
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| creator | Fulghesu, Anna Maria Ciampelli, Mario Muzj, Giuseppe Belosi, Chiara Selvaggi, Luigi Ayala, Gian Franco Lanzone, Antonio |
| description | Objective: To evaluate the effect of N-acetyl-cysteine (NAC) on insulin secretion and peripheral insulin resistance in subjects with polycystic ovary syndrome (PCOS).
Design: Prospective data analysis.
Setting: Volunteer women in an academic research environment.
Patient(s): Six lean and 31 obese subjects, aged 19–33 years.
Intervention(s): Patients were treated for 5–6 weeks with NAC at a dose of 1.8 g/day orally. A dose of 3 g/day was arbitrarily chosen for massively obese subjects. Six of 31 obese patients with PCOS were treated with placebo and served as controls.
Main Outcome Measure(s): Before and after the treatment period, the hormonal and lipid blood profile and insulin sensitivity, assessed by an hyperinsulinemic euglycemic clamp, were evaluated and an oral glucose tolerance test (OGTT) was performed.
Result(s): Fasting glucose, fasting insulin, and glucose area under curve (AUC) were unchanged after treatment. Insulin AUC after OGTT was significantly reduced, and the peripheral insulin sensitivity increased after NAC administration, whereas the hepatic insulin extraction was unaffected. The NAC treatment induced a significant fall in T levels and in free androgen index values (
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| doi_str_mv | 10.1016/S0015-0282(02)03133-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71820854</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0015028202031333</els_id><sourcerecordid>71820854</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-4a2f8431d246b1c4fcbf0df4f6f1f7ef3f1541918eb135e78151d7537405f28b3</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi0EotvCT6DyBdQeAh5_xOkJoYq2SBUcgLNxnLFwlThb27tV_j3e7qo9chlL42dmXj2EvAP2ERi0n34yBqphvONnjJ8zAUI04gVZgVJto1olXpLVE3JEjnO-Y4y1oPlrcgScKa1Br8if7411WJaxcUsuGCLSktCWCWOhYVqneYuZhpg3Y4g0Y8yhhG0oS-3Rh7li9CGUv3Q9j8tuQ3B03tq00LzEIdX_N-SVt2PGt4f3hPy--vrr8qa5_XH97fLLbeOk6EojLfedFDBw2fbgpHe9Z4OXvvXgNXrhQUm4gA57EAp1BwoGrYSWTHne9eKEfNjvrZHvN5iLmUJ2OI424rzJRkPHWadkBdUedGnOOaE36xSmGtkAMzu15lGt2XmrxTyqNaLOnR4ObPoJh-epg8sKvD8ANjs7-mSjC_mZE1pcMA2V-7znsOrYBkwmu4DR4RASumKGOfwnyj8vbJc0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71820854</pqid></control><display><type>article</type><title>N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Fulghesu, Anna Maria ; Ciampelli, Mario ; Muzj, Giuseppe ; Belosi, Chiara ; Selvaggi, Luigi ; Ayala, Gian Franco ; Lanzone, Antonio</creator><creatorcontrib>Fulghesu, Anna Maria ; Ciampelli, Mario ; Muzj, Giuseppe ; Belosi, Chiara ; Selvaggi, Luigi ; Ayala, Gian Franco ; Lanzone, Antonio</creatorcontrib><description>Objective: To evaluate the effect of N-acetyl-cysteine (NAC) on insulin secretion and peripheral insulin resistance in subjects with polycystic ovary syndrome (PCOS).
Design: Prospective data analysis.
Setting: Volunteer women in an academic research environment.
Patient(s): Six lean and 31 obese subjects, aged 19–33 years.
Intervention(s): Patients were treated for 5–6 weeks with NAC at a dose of 1.8 g/day orally. A dose of 3 g/day was arbitrarily chosen for massively obese subjects. Six of 31 obese patients with PCOS were treated with placebo and served as controls.
Main Outcome Measure(s): Before and after the treatment period, the hormonal and lipid blood profile and insulin sensitivity, assessed by an hyperinsulinemic euglycemic clamp, were evaluated and an oral glucose tolerance test (OGTT) was performed.
Result(s): Fasting glucose, fasting insulin, and glucose area under curve (AUC) were unchanged after treatment. Insulin AUC after OGTT was significantly reduced, and the peripheral insulin sensitivity increased after NAC administration, whereas the hepatic insulin extraction was unaffected. The NAC treatment induced a significant fall in T levels and in free androgen index values (
P<.05). In analyzing patients according to their insulinemic response to OGTT, normoinsulinemic subjects and placebo-treated patients did not show any modification of the above parameters, whereas a significant improvement was observed in hyperinsulinemic subjects.
Conclusion(s): NAC may be a new treatment for the improvement of insulin circulating levels and insulin sensitivity in hyperinsulinemic patients with polycystic ovary syndrome.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(02)03133-3</identifier><identifier>PMID: 12057717</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acetylcysteine - administration & dosage ; Acetylcysteine - therapeutic use ; Adult ; Androgens - blood ; Biological and medical sciences ; Drug Administration Schedule ; Female ; Female genital diseases ; Glucose Tolerance Test ; Gynecology. Andrology. Obstetrics ; Humans ; Hyperinsulinism - blood ; insulin ; Insulin - blood ; Insulin - metabolism ; insulin resistance ; Insulin Resistance - physiology ; Liver - metabolism ; Medical sciences ; N-acetyl-cysteine ; obesity ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - drug therapy ; Polycystic Ovary Syndrome - physiopathology ; Prospective Studies ; Testosterone - blood ; Tumors</subject><ispartof>Fertility and sterility, 2002-06, Vol.77 (6), p.1128-1135</ispartof><rights>2002 American Society for Reproductive Medicine</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-4a2f8431d246b1c4fcbf0df4f6f1f7ef3f1541918eb135e78151d7537405f28b3</citedby><cites>FETCH-LOGICAL-c438t-4a2f8431d246b1c4fcbf0df4f6f1f7ef3f1541918eb135e78151d7537405f28b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028202031333$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13739071$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12057717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fulghesu, Anna Maria</creatorcontrib><creatorcontrib>Ciampelli, Mario</creatorcontrib><creatorcontrib>Muzj, Giuseppe</creatorcontrib><creatorcontrib>Belosi, Chiara</creatorcontrib><creatorcontrib>Selvaggi, Luigi</creatorcontrib><creatorcontrib>Ayala, Gian Franco</creatorcontrib><creatorcontrib>Lanzone, Antonio</creatorcontrib><title>N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective: To evaluate the effect of N-acetyl-cysteine (NAC) on insulin secretion and peripheral insulin resistance in subjects with polycystic ovary syndrome (PCOS).
Design: Prospective data analysis.
Setting: Volunteer women in an academic research environment.
Patient(s): Six lean and 31 obese subjects, aged 19–33 years.
Intervention(s): Patients were treated for 5–6 weeks with NAC at a dose of 1.8 g/day orally. A dose of 3 g/day was arbitrarily chosen for massively obese subjects. Six of 31 obese patients with PCOS were treated with placebo and served as controls.
Main Outcome Measure(s): Before and after the treatment period, the hormonal and lipid blood profile and insulin sensitivity, assessed by an hyperinsulinemic euglycemic clamp, were evaluated and an oral glucose tolerance test (OGTT) was performed.
Result(s): Fasting glucose, fasting insulin, and glucose area under curve (AUC) were unchanged after treatment. Insulin AUC after OGTT was significantly reduced, and the peripheral insulin sensitivity increased after NAC administration, whereas the hepatic insulin extraction was unaffected. The NAC treatment induced a significant fall in T levels and in free androgen index values (
P<.05). In analyzing patients according to their insulinemic response to OGTT, normoinsulinemic subjects and placebo-treated patients did not show any modification of the above parameters, whereas a significant improvement was observed in hyperinsulinemic subjects.
Conclusion(s): NAC may be a new treatment for the improvement of insulin circulating levels and insulin sensitivity in hyperinsulinemic patients with polycystic ovary syndrome.</description><subject>Acetylcysteine - administration & dosage</subject><subject>Acetylcysteine - therapeutic use</subject><subject>Adult</subject><subject>Androgens - blood</subject><subject>Biological and medical sciences</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Glucose Tolerance Test</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hyperinsulinism - blood</subject><subject>insulin</subject><subject>Insulin - blood</subject><subject>Insulin - metabolism</subject><subject>insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Liver - metabolism</subject><subject>Medical sciences</subject><subject>N-acetyl-cysteine</subject><subject>obesity</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - drug therapy</subject><subject>Polycystic Ovary Syndrome - physiopathology</subject><subject>Prospective Studies</subject><subject>Testosterone - blood</subject><subject>Tumors</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EotvCT6DyBdQeAh5_xOkJoYq2SBUcgLNxnLFwlThb27tV_j3e7qo9chlL42dmXj2EvAP2ERi0n34yBqphvONnjJ8zAUI04gVZgVJto1olXpLVE3JEjnO-Y4y1oPlrcgScKa1Br8if7411WJaxcUsuGCLSktCWCWOhYVqneYuZhpg3Y4g0Y8yhhG0oS-3Rh7li9CGUv3Q9j8tuQ3B03tq00LzEIdX_N-SVt2PGt4f3hPy--vrr8qa5_XH97fLLbeOk6EojLfedFDBw2fbgpHe9Z4OXvvXgNXrhQUm4gA57EAp1BwoGrYSWTHne9eKEfNjvrZHvN5iLmUJ2OI424rzJRkPHWadkBdUedGnOOaE36xSmGtkAMzu15lGt2XmrxTyqNaLOnR4ObPoJh-epg8sKvD8ANjs7-mSjC_mZE1pcMA2V-7znsOrYBkwmu4DR4RASumKGOfwnyj8vbJc0</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Fulghesu, Anna Maria</creator><creator>Ciampelli, Mario</creator><creator>Muzj, Giuseppe</creator><creator>Belosi, Chiara</creator><creator>Selvaggi, Luigi</creator><creator>Ayala, Gian Franco</creator><creator>Lanzone, Antonio</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome</title><author>Fulghesu, Anna Maria ; Ciampelli, Mario ; Muzj, Giuseppe ; Belosi, Chiara ; Selvaggi, Luigi ; Ayala, Gian Franco ; Lanzone, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-4a2f8431d246b1c4fcbf0df4f6f1f7ef3f1541918eb135e78151d7537405f28b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acetylcysteine - administration & dosage</topic><topic>Acetylcysteine - therapeutic use</topic><topic>Adult</topic><topic>Androgens - blood</topic><topic>Biological and medical sciences</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Glucose Tolerance Test</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hyperinsulinism - blood</topic><topic>insulin</topic><topic>Insulin - blood</topic><topic>Insulin - metabolism</topic><topic>insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Liver - metabolism</topic><topic>Medical sciences</topic><topic>N-acetyl-cysteine</topic><topic>obesity</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - drug therapy</topic><topic>Polycystic Ovary Syndrome - physiopathology</topic><topic>Prospective Studies</topic><topic>Testosterone - blood</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fulghesu, Anna Maria</creatorcontrib><creatorcontrib>Ciampelli, Mario</creatorcontrib><creatorcontrib>Muzj, Giuseppe</creatorcontrib><creatorcontrib>Belosi, Chiara</creatorcontrib><creatorcontrib>Selvaggi, Luigi</creatorcontrib><creatorcontrib>Ayala, Gian Franco</creatorcontrib><creatorcontrib>Lanzone, Antonio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fulghesu, Anna Maria</au><au>Ciampelli, Mario</au><au>Muzj, Giuseppe</au><au>Belosi, Chiara</au><au>Selvaggi, Luigi</au><au>Ayala, Gian Franco</au><au>Lanzone, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>77</volume><issue>6</issue><spage>1128</spage><epage>1135</epage><pages>1128-1135</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective: To evaluate the effect of N-acetyl-cysteine (NAC) on insulin secretion and peripheral insulin resistance in subjects with polycystic ovary syndrome (PCOS).
Design: Prospective data analysis.
Setting: Volunteer women in an academic research environment.
Patient(s): Six lean and 31 obese subjects, aged 19–33 years.
Intervention(s): Patients were treated for 5–6 weeks with NAC at a dose of 1.8 g/day orally. A dose of 3 g/day was arbitrarily chosen for massively obese subjects. Six of 31 obese patients with PCOS were treated with placebo and served as controls.
Main Outcome Measure(s): Before and after the treatment period, the hormonal and lipid blood profile and insulin sensitivity, assessed by an hyperinsulinemic euglycemic clamp, were evaluated and an oral glucose tolerance test (OGTT) was performed.
Result(s): Fasting glucose, fasting insulin, and glucose area under curve (AUC) were unchanged after treatment. Insulin AUC after OGTT was significantly reduced, and the peripheral insulin sensitivity increased after NAC administration, whereas the hepatic insulin extraction was unaffected. The NAC treatment induced a significant fall in T levels and in free androgen index values (
P<.05). In analyzing patients according to their insulinemic response to OGTT, normoinsulinemic subjects and placebo-treated patients did not show any modification of the above parameters, whereas a significant improvement was observed in hyperinsulinemic subjects.
Conclusion(s): NAC may be a new treatment for the improvement of insulin circulating levels and insulin sensitivity in hyperinsulinemic patients with polycystic ovary syndrome.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12057717</pmid><doi>10.1016/S0015-0282(02)03133-3</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acetylcysteine - administration & dosage Acetylcysteine - therapeutic use Adult Androgens - blood Biological and medical sciences Drug Administration Schedule Female Female genital diseases Glucose Tolerance Test Gynecology. Andrology. Obstetrics Humans Hyperinsulinism - blood insulin Insulin - blood Insulin - metabolism insulin resistance Insulin Resistance - physiology Liver - metabolism Medical sciences N-acetyl-cysteine obesity Polycystic ovary syndrome Polycystic Ovary Syndrome - drug therapy Polycystic Ovary Syndrome - physiopathology Prospective Studies Testosterone - blood Tumors |
| title | N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome |
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