Synthesis and biological activity of novel α-substituted β-phenylpropionic acids having pyridin-2-ylphenyl moiety as antihyperglycemic agents

Graphic We previously reported the identification of novel oximes having 5-benzyl-2,4-thiazolidinedione with antihyperglycemic activity. We now report the synthesis and biological activity of a novel series of oximes and amides having α-substituted-β-phenylpropionic acids. In this series, we obtaine...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2004-05, Vol.12 (9), p.2419-2439
Hauptverfasser: Takamura, Makoto, Sakurai, Mitsuya, Yamada, Eriko, Fujita, Sachie, Yachi, Makoto, Takagi, Toshiyuki, Isobe, Aya, Hagisawa, Yuka, Fujiwara, Toshihiko, Yanagisawa, Hiroaki
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Sprache:eng
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