Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data

Motivations: Classification of biological samples for diagnostic purposes is a difficult task because of the many decisions involved on the number, type and functional manipulations of the input variables. This study presents a generally applicable strategy for systematic formulation of optimal diag...

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Veröffentlicht in:	Bioinformatics 2004-04, Vol.20 (6), p.959-969
Hauptverfasser:	Lee, Kyongbum, Hwang, Daehee, Yokoyama, Tadaaki, Stephanopoulos, George, Stephanopoulos, Gregory N., Yarmush, Martin L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Amino Acids - metabolism Ammonia - metabolism Animals Biological and medical sciences Biomarkers - blood Diagnosis, Computer-Assisted - methods Fundamental and applied biological sciences. Psychology Galactosamine General aspects Glucose - metabolism Ketone Bodies - metabolism Lactic Acid - metabolism Liver Failure - blood Liver Failure - diagnosis Liver Failure - metabolism Male Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Metabolic Clearance Rate Models, Biological Models, Statistical Multivariate Analysis Organ Specificity Rats Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity Urea - metabolism
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