Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors

Modification of imidazo[1,2-a]pyridine CDK inhibitors lead to identification of less lipophilic imidazo[1,2-b]pyridazine series of CDK inhibitors. Although several equivalent compounds from these two series have similar structure and show similar CDK activity, the SAR of the two series differs signi...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-05, Vol.14 (9), p.2249-2252
Hauptverfasser:	BYTH, Kate F, COOPER, Nicola, PANNIFER, Andrew, ROWSELL, Sian, STANWAY, Judith J, VALENTINE, Anna L, THOMAS, Andrew P, CULSHAW, Janet D, HEATON, David W, OAKES, Sandra E, MINSHULL, Claire A, NORMAN, Richard A, PAUPTIT, Richard A, TUCKER, Julie A, BREED, Jason
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cyclin-Dependent Kinases - antagonists & inhibitors Enzyme Inhibitors - blood Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General aspects Medical sciences Mice Models, Molecular Pharmacology. Drug treatments Pyridazines - blood Pyridazines - chemistry Pyridazines - pharmacology
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