Human Wild-Type Tau Interacts with wingless Pathway Components and Produces Neurofibrillary Pathology in Drosophila

Pathologic alterations in the microtubule-associated protein tau have been implicated in a number of neurodegenerative disorders, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP), and frontotemporal dementia (FTD). Here, we show that tau overexpression, in combination wi...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2002-05, Vol.34 (4), p.509-519
Hauptverfasser:	Jackson, George R, Wiedau-Pazos, Martina, Sang, Tzu-Kang, Wagle, Naveed, Brown, Carlos A, Massachi, Sasan, Geschwind, Daniel H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Apoptosis - genetics Armadillo Domain Proteins beta Catenin Calcium-Calmodulin-Dependent Protein Kinases - genetics Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Disease Models, Animal Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila melanogaster - ultrastructure Drosophila Proteins Eye Abnormalities - genetics Eye Abnormalities - metabolism Eye Abnormalities - pathology Genotype & phenotype Glycogen Synthase Kinase 3 Glycogen Synthase Kinases High Mobility Group Proteins - genetics High Mobility Group Proteins - metabolism Humans Inhibitor of Apoptosis Proteins Insect Proteins - genetics Insect Proteins - metabolism Insect Proteins - ultrastructure Insects Kinases Mutation Mutation - genetics Nervous System Malformations - genetics Nervous System Malformations - metabolism Nervous System Malformations - pathology Neurodegeneration Neurofibrillary Tangles - genetics Neurofibrillary Tangles - pathology Neurofibrillary Tangles - ultrastructure Pathology Phenotype Phosphorylation Photoreceptor Cells, Invertebrate - abnormalities Photoreceptor Cells, Invertebrate - pathology Photoreceptor Cells, Invertebrate - ultrastructure Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Repressor Proteins - genetics Repressor Proteins - metabolism Scanning electron microscopy tau Proteins - genetics tau Proteins - metabolism tau Proteins - ultrastructure Trans-Activators Transcription Factors Transgenes - genetics
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