Hypothalamic neuropeptide release after experimental subarachnoid hemorrhage: in vivo microdialysis study
Objectives – As evidence exists about independent regulation of peripheral and central release of the vasoactive and natriuretic neuropeptides arginine–vasopressin (AVP) and oxytocin (OXT), we investigated their release patterns following subarachnoid hemorrhage (SAH). Materials and methods – After...
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| Veröffentlicht in: | Acta neurologica Scandinavica 2004-05, Vol.109 (5), p.361-368 |
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| container_title | Acta neurologica Scandinavica |
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| creator | Kleindienst, A. Hildebrandt, G. Kroemer, S. A. Franke, G. Gaab, M. R. Landgraf, R. |
| description | Objectives – As evidence exists about independent regulation of peripheral and central release of the vasoactive and natriuretic neuropeptides arginine–vasopressin (AVP) and oxytocin (OXT), we investigated their release patterns following subarachnoid hemorrhage (SAH).
Materials and methods – After injection of 0.1 ml arterial blood or saline into the great cistern of 33 Wistar rats, AVP and OXT levels were measured in blood and by microdialysis in the hypothalamic supraoptic (SON) and paraventricular nucleus (PVN). For statistical analysis, the analysis of variance (ANOVA) was used with Tukey HSD post hoc ANOVA tests to determine specific group differences.
Results – Plasma AVP and OXT peaked 2 h after SAH (P |
| doi_str_mv | 10.1046/j.1600-0404.2003.00245.x |
| format | Article |
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Materials and methods – After injection of 0.1 ml arterial blood or saline into the great cistern of 33 Wistar rats, AVP and OXT levels were measured in blood and by microdialysis in the hypothalamic supraoptic (SON) and paraventricular nucleus (PVN). For statistical analysis, the analysis of variance (ANOVA) was used with Tukey HSD post hoc ANOVA tests to determine specific group differences.
Results – Plasma AVP and OXT peaked 2 h after SAH (P < 0.05), and normalized at 4 h. In the SON, both AVP and OXT peaked 4 h after SAH (P < 0.05). In the PVN, AVP increased in both groups (P < 0.05), while no OXT release occurred. By the sham group, any effect of experimental procedure was excluded.
Conclusions – The SAH‐specific central neuropeptide release, which exceeded peripheral release and continued longer, may contribute to pathophysiological events following SAH.</description><identifier>ISSN: 0001-6314</identifier><identifier>EISSN: 1600-0404</identifier><identifier>DOI: 10.1046/j.1600-0404.2003.00245.x</identifier><identifier>PMID: 15080864</identifier><identifier>CODEN: ANRSAS</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing</publisher><subject>Animals ; Arginine Vasopressin - metabolism ; Biological and medical sciences ; experimental subarachnoid hemorrhage ; Hypothalamus - pathology ; Male ; Medical sciences ; microdialysis ; Neurology ; Neuropeptides - metabolism ; oxytocin ; Oxytocin - metabolism ; Paraventricular Hypothalamic Nucleus - pathology ; paraventricular nucleus ; Rats ; Rats, Wistar ; Subarachnoid Hemorrhage - pathology ; supraoptic nucleus ; Supraoptic Nucleus - pathology ; vasopressin</subject><ispartof>Acta neurologica Scandinavica, 2004-05, Vol.109 (5), p.361-368</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4825-641a37ee9ea3602de98cb26957d41f1b5b2c4070b3c934aada344a272db533c33</citedby><cites>FETCH-LOGICAL-c4825-641a37ee9ea3602de98cb26957d41f1b5b2c4070b3c934aada344a272db533c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1600-0404.2003.00245.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1600-0404.2003.00245.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15679645$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15080864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kleindienst, A.</creatorcontrib><creatorcontrib>Hildebrandt, G.</creatorcontrib><creatorcontrib>Kroemer, S. A.</creatorcontrib><creatorcontrib>Franke, G.</creatorcontrib><creatorcontrib>Gaab, M. R.</creatorcontrib><creatorcontrib>Landgraf, R.</creatorcontrib><title>Hypothalamic neuropeptide release after experimental subarachnoid hemorrhage: in vivo microdialysis study</title><title>Acta neurologica Scandinavica</title><addtitle>Acta Neurol Scand</addtitle><description>Objectives – As evidence exists about independent regulation of peripheral and central release of the vasoactive and natriuretic neuropeptides arginine–vasopressin (AVP) and oxytocin (OXT), we investigated their release patterns following subarachnoid hemorrhage (SAH).
Materials and methods – After injection of 0.1 ml arterial blood or saline into the great cistern of 33 Wistar rats, AVP and OXT levels were measured in blood and by microdialysis in the hypothalamic supraoptic (SON) and paraventricular nucleus (PVN). For statistical analysis, the analysis of variance (ANOVA) was used with Tukey HSD post hoc ANOVA tests to determine specific group differences.
Results – Plasma AVP and OXT peaked 2 h after SAH (P < 0.05), and normalized at 4 h. In the SON, both AVP and OXT peaked 4 h after SAH (P < 0.05). In the PVN, AVP increased in both groups (P < 0.05), while no OXT release occurred. By the sham group, any effect of experimental procedure was excluded.
Conclusions – The SAH‐specific central neuropeptide release, which exceeded peripheral release and continued longer, may contribute to pathophysiological events following SAH.</description><subject>Animals</subject><subject>Arginine Vasopressin - metabolism</subject><subject>Biological and medical sciences</subject><subject>experimental subarachnoid hemorrhage</subject><subject>Hypothalamus - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>microdialysis</subject><subject>Neurology</subject><subject>Neuropeptides - metabolism</subject><subject>oxytocin</subject><subject>Oxytocin - metabolism</subject><subject>Paraventricular Hypothalamic Nucleus - pathology</subject><subject>paraventricular nucleus</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Subarachnoid Hemorrhage - pathology</subject><subject>supraoptic nucleus</subject><subject>Supraoptic Nucleus - pathology</subject><subject>vasopressin</subject><issn>0001-6314</issn><issn>1600-0404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtu1DAUQC0EokPhF5A3sEvqV-wEsSlV6SBVRUIgurNunBvGQ161kzL5-2Y6o8KSlWX5HPv6EEI5SzlT-mybcs1YwhRTqWBMpowJlaW7Z2T1dPCcrBhjPNGSqxPyKsbtshNGqZfkhGcsZ7lWK-LX89CPG2ig9Y52OIV-wGH0FdKADUJECvWIgeJuwOBb7EZoaJxKCOA2Xe8rusG2D2EDv_AD9R299_c9XS4LfeWhmaOPNI5TNb8mL2poIr45rqfkx-fL7xfr5Prr1ZeL8-vEqVxkiVYcpEEsEKRmosIid6XQRWYqxWteZqVwihlWSldIBVCBVAqEEVWZSemkPCXvD_cOob-bMI629dFh00CH_RSt4Tk3nOkFzA_gMmqMAWs7LB-EMFvO7D6z3dp9TbuvafeZ7WNmu1vUt8c3prLF6q947LoA744ARAdNHaBzPv7DaVNolS3cxwP3xzc4__cA9vzmUjzqyUH3ccTdkw7ht9VGmsz-vLlanG-3Ut2u7Sf5AFnOqSs</recordid><startdate>200405</startdate><enddate>200405</enddate><creator>Kleindienst, A.</creator><creator>Hildebrandt, G.</creator><creator>Kroemer, S. A.</creator><creator>Franke, G.</creator><creator>Gaab, M. R.</creator><creator>Landgraf, R.</creator><general>Blackwell Publishing</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200405</creationdate><title>Hypothalamic neuropeptide release after experimental subarachnoid hemorrhage: in vivo microdialysis study</title><author>Kleindienst, A. ; Hildebrandt, G. ; Kroemer, S. A. ; Franke, G. ; Gaab, M. R. ; Landgraf, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4825-641a37ee9ea3602de98cb26957d41f1b5b2c4070b3c934aada344a272db533c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Arginine Vasopressin - metabolism</topic><topic>Biological and medical sciences</topic><topic>experimental subarachnoid hemorrhage</topic><topic>Hypothalamus - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>microdialysis</topic><topic>Neurology</topic><topic>Neuropeptides - metabolism</topic><topic>oxytocin</topic><topic>Oxytocin - metabolism</topic><topic>Paraventricular Hypothalamic Nucleus - pathology</topic><topic>paraventricular nucleus</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Subarachnoid Hemorrhage - pathology</topic><topic>supraoptic nucleus</topic><topic>Supraoptic Nucleus - pathology</topic><topic>vasopressin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kleindienst, A.</creatorcontrib><creatorcontrib>Hildebrandt, G.</creatorcontrib><creatorcontrib>Kroemer, S. A.</creatorcontrib><creatorcontrib>Franke, G.</creatorcontrib><creatorcontrib>Gaab, M. R.</creatorcontrib><creatorcontrib>Landgraf, R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kleindienst, A.</au><au>Hildebrandt, G.</au><au>Kroemer, S. A.</au><au>Franke, G.</au><au>Gaab, M. R.</au><au>Landgraf, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypothalamic neuropeptide release after experimental subarachnoid hemorrhage: in vivo microdialysis study</atitle><jtitle>Acta neurologica Scandinavica</jtitle><addtitle>Acta Neurol Scand</addtitle><date>2004-05</date><risdate>2004</risdate><volume>109</volume><issue>5</issue><spage>361</spage><epage>368</epage><pages>361-368</pages><issn>0001-6314</issn><eissn>1600-0404</eissn><coden>ANRSAS</coden><abstract>Objectives – As evidence exists about independent regulation of peripheral and central release of the vasoactive and natriuretic neuropeptides arginine–vasopressin (AVP) and oxytocin (OXT), we investigated their release patterns following subarachnoid hemorrhage (SAH).
Materials and methods – After injection of 0.1 ml arterial blood or saline into the great cistern of 33 Wistar rats, AVP and OXT levels were measured in blood and by microdialysis in the hypothalamic supraoptic (SON) and paraventricular nucleus (PVN). For statistical analysis, the analysis of variance (ANOVA) was used with Tukey HSD post hoc ANOVA tests to determine specific group differences.
Results – Plasma AVP and OXT peaked 2 h after SAH (P < 0.05), and normalized at 4 h. In the SON, both AVP and OXT peaked 4 h after SAH (P < 0.05). In the PVN, AVP increased in both groups (P < 0.05), while no OXT release occurred. By the sham group, any effect of experimental procedure was excluded.
Conclusions – The SAH‐specific central neuropeptide release, which exceeded peripheral release and continued longer, may contribute to pathophysiological events following SAH.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing</pub><pmid>15080864</pmid><doi>10.1046/j.1600-0404.2003.00245.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Arginine Vasopressin - metabolism Biological and medical sciences experimental subarachnoid hemorrhage Hypothalamus - pathology Male Medical sciences microdialysis Neurology Neuropeptides - metabolism oxytocin Oxytocin - metabolism Paraventricular Hypothalamic Nucleus - pathology paraventricular nucleus Rats Rats, Wistar Subarachnoid Hemorrhage - pathology supraoptic nucleus Supraoptic Nucleus - pathology vasopressin |
| title | Hypothalamic neuropeptide release after experimental subarachnoid hemorrhage: in vivo microdialysis study |
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