COEXPRESSION OF ONCOSTATIN M AND ITS RECEPTORS AND EVIDENCE FOR STAT3 ACTIVATION IN HUMAN OVARIAN CARCINOMAS

The expression of oncostatin M and leukemia inhibitory factor (LIF), JAK-STAT activators and members of the interleukin-6 family of cytokines, were examined in a series of primary ovarian carcinomas using immunohistochemistry. The malignant epithelial cells of all 29 ovarian carcinomas examined expr...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2002-03, Vol.17 (6), p.324-334
Hauptverfasser:	Savarese, Todd M., Campbell, Cara L., McQuain, Catherine, Mitchell, Kathryn, Guardiani, Rachel, Quesenberry, Peter J., Nelson, Beth E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - metabolism Amino Acid Sequence Apoptosis Base Sequence Carcinoma - classification Carcinoma - genetics Carcinoma - pathology Cell Death Cytokines - genetics DNA Primers DNA-Binding Proteins - metabolism Female Humans LIFRβ/oncostatin M/OSMRβ/ovarian cancer/STAT3 Molecular Sequence Data Neoplasm Staging Oncostatin M Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Peptide Fragments Peptides - genetics Phosphotyrosine - analysis Receptors, Cytokine - genetics Receptors, Oncostatin M Reverse Transcriptase Polymerase Chain Reaction STAT3 Transcription Factor Trans-Activators - metabolism Transcription, Genetic Tumor Cells, Cultured
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