Picrotoxin and bicuculline have different effects on lumbar spinal networks and motoneurons in the neonatal rat

Bicuculline is the most commonly used GABA A receptor antagonist to investigate the contribution of these receptors in motor control. However, this compound has been shown recently to potentiate the burst firing of neurons in various brain regions by blocking a calcium-activated potassium current un...

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Veröffentlicht in:	Brain research 2002-05, Vol.935 (1), p.81-86
Hauptverfasser:	Pflieger, Jean-François, Clarac, François, Vinay, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - pharmacology 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Action Potentials - drug effects Action Potentials - physiology Animals Animals, Newborn Bicuculline Bicuculline - pharmacology Biological and medical sciences Central pattern generator Disinhibition Excitatory Amino Acid Antagonists Fundamental and applied biological sciences. Psychology GABA A receptor GABA Antagonists - pharmacology GABA-A Receptor Antagonists gamma-Aminobutyric Acid - metabolism Interneurons - cytology Interneurons - drug effects Interneurons - metabolism Locomotion Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Motor Neurons - cytology Motor Neurons - drug effects Motor Neurons - metabolism Nerve Net - cytology Nerve Net - drug effects Nerve Net - metabolism Neural Inhibition - drug effects Neural Inhibition - physiology Neural Pathways - cytology Neural Pathways - drug effects Neural Pathways - metabolism Picrotoxin - pharmacology Rats Rats, Wistar Receptors, GABA-A - metabolism Spinal Cord - cytology Spinal Cord - drug effects Spinal Cord - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology Vertebrates: nervous system and sense organs
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