Visually Driven Modulation of Glutamatergic Synaptic Transmission Is Mediated by the Regulation of Intracellular Polyamines

Ca 2+-permeable AMPARs are inwardly rectifying due to block by intracellular polyamines. Neuronal activity regulates polyamine synthesis, yet whether this affects Ca 2+-AMPAR-mediated synaptic transmission is unknown. We test whether 4 hr of increased visual stimulation regulates glutamatergic retin...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2002-05, Vol.34 (4), p.623-634
Hauptverfasser:	Aizenman, Carlos D, Muñoz-Elı́as, Guillermo, Cline, Hollis T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biogenic Polyamines - metabolism Biogenic Polyamines - pharmacology Calcium Signaling - drug effects Calcium Signaling - physiology Cell Differentiation - drug effects Cell Differentiation - physiology Cell division Cell Membrane Permeability - drug effects Cell Membrane Permeability - physiology Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Glutamic Acid - metabolism Information storage Ion Channels - drug effects Ion Channels - metabolism Larva Neurons Photic Stimulation Polyamines Presynaptic Terminals - metabolism Presynaptic Terminals - ultrastructure Receptors, AMPA - drug effects Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - metabolism Retina - cytology Retina - growth & development Retina - metabolism Spermine - metabolism Spermine - pharmacology Superior Colliculi - cytology Superior Colliculi - growth & development Superior Colliculi - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology Visual Pathways - cytology Visual Pathways - growth & development Visual Pathways - metabolism Xenopus laevis
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