Overexpression of sTnC polypeptide in muscle cells is controlled by its rapid degradation

The check-points that maintain stoichiometric synthesis of muscle proteins were examined by misexpression of slow troponin C (sTnC) in mouse C2 myotubes. The sTnC mRNA was overexpressed in myotubes by transfecting these cells with a plasmid construct containing the constitutive CMV promoter-driven s...

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Veröffentlicht in:	FEBS letters 2002-04, Vol.517 (1), p.45-49
Hauptverfasser:	Yin, Xingping, Choudhury, Monideepa, Bag, Jnanankur
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Gene Expression Regulation, Developmental Hydrolysis Mice Muscle protein Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Overexpression Protein Biosynthesis Protein degradation RNA, Messenger - biosynthesis RNA, Messenger - metabolism sTnC, slow/cardiac troponin C Tm, tropomyosin TnI, troponin I TnT, troponin T Transfection Troponin C Troponin C - biosynthesis Troponin C - genetics Troponin C - metabolism
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