Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation

We explored, by cDNA mini-arrays, gene expression measurements of MVLN, a human breast carcinoma cell line derived from MCF-7, after 4 days of exposure to 17beta-estradiol (E(2)) treatment, in order to extend our understanding of the mechanism of the pharmacological action of estrogens. We focused o...

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Veröffentlicht in:	Journal of molecular endocrinology 2004-04, Vol.32 (2), p.397-414
Hauptverfasser:	Vendrell, JA, Magnino, F, Danis, E, Duchesne, MJ, Pinloche, S, Pons, M, Birnbaum, D, Nguyen, C, Theillet, C, Cohen, PA
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Proliferation - drug effects Cell Transformation, Neoplastic Cycloheximide - pharmacology Estradiol - analogs & derivatives Estradiol - pharmacology Estrogen Antagonists - pharmacology Estrogens - metabolism Estrogens - pharmacology Gene Expression Regulation, Neoplastic - drug effects Humans Neoplasm Proteins - drug effects Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oligonucleotide Array Sequence Analysis Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction Tamoxifen - analogs & derivatives Tamoxifen - pharmacology Time Factors Tumor Cells, Cultured
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