IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma
Identical twins of young adult Hodgkin lymphoma case subjects are much more likely to develop the disease compared with fraternal twins of case subjects, suggesting a genetic determinant. Interleukin 6 (IL-6) levels are increased in patients with Hodgkin lymphoma and are correlated with a poor progn...
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| Veröffentlicht in: | Blood 2004-04, Vol.103 (8), p.3216-3221 |
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| creator | Cozen, Wendy Gill, Parkash S. Ingles, Sue Ann Masood, Rizwan Martínez-Maza, Otoniel Cockburn, Myles G. Gauderman, W. James Pike, Malcolm C. Bernstein, Leslie Nathwani, Bharat N. Salam, Muhammad T. Danley, Kathleen Lackerdas Wang, Wei Gage, Julia Gundell-Miller, Susan Mack, Thomas M. |
| description | Identical twins of young adult Hodgkin lymphoma case subjects are much more likely to develop the disease compared with fraternal twins of case subjects, suggesting a genetic determinant. Interleukin 6 (IL-6) levels are increased in patients with Hodgkin lymphoma and are correlated with a poor prognosis. We hypothesized that a heritable abnormality in IL-6 regulation may predispose to young adult Hodgkin lymphoma. We obtained blood specimens from 88 young adult Hodgkin lymphoma case subjects and their twins as well as from 87 matched control subjects. IL-6 was measured from unstimulated peripheral blood mononuclear cell (PBMC) supernatant with enzyme-linked immunosorbent assays (ELISAs) and compared by using analysis of covariance. Unaffected identical twins of case subjects (surrogate case subjects) had a 87.8% higher IL-6 level compared with matched control subjects (mean difference, +483.7 pg/mL,P= .04). Analysis of the IL-6 174G>C promoter polymorphism genotypes showed that risk decreased with an increasing number of C alleles (P= .01). The CC (low secreting) genotype was associated with a decreased risk of young adult Hodgkin lymphoma relative to the GG (high secreting) genotype (odds ratio [OR] = .29;P= .03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma. (Blood. 2004;103:3216-3221) |
| doi_str_mv | 10.1182/blood-2003-08-2860 |
| format | Article |
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James ; Pike, Malcolm C. ; Bernstein, Leslie ; Nathwani, Bharat N. ; Salam, Muhammad T. ; Danley, Kathleen Lackerdas ; Wang, Wei ; Gage, Julia ; Gundell-Miller, Susan ; Mack, Thomas M.</creator><creatorcontrib>Cozen, Wendy ; Gill, Parkash S. ; Ingles, Sue Ann ; Masood, Rizwan ; Martínez-Maza, Otoniel ; Cockburn, Myles G. ; Gauderman, W. James ; Pike, Malcolm C. ; Bernstein, Leslie ; Nathwani, Bharat N. ; Salam, Muhammad T. ; Danley, Kathleen Lackerdas ; Wang, Wei ; Gage, Julia ; Gundell-Miller, Susan ; Mack, Thomas M.</creatorcontrib><description>Identical twins of young adult Hodgkin lymphoma case subjects are much more likely to develop the disease compared with fraternal twins of case subjects, suggesting a genetic determinant. Interleukin 6 (IL-6) levels are increased in patients with Hodgkin lymphoma and are correlated with a poor prognosis. We hypothesized that a heritable abnormality in IL-6 regulation may predispose to young adult Hodgkin lymphoma. We obtained blood specimens from 88 young adult Hodgkin lymphoma case subjects and their twins as well as from 87 matched control subjects. IL-6 was measured from unstimulated peripheral blood mononuclear cell (PBMC) supernatant with enzyme-linked immunosorbent assays (ELISAs) and compared by using analysis of covariance. Unaffected identical twins of case subjects (surrogate case subjects) had a 87.8% higher IL-6 level compared with matched control subjects (mean difference, +483.7 pg/mL,P= .04). Analysis of the IL-6 174G>C promoter polymorphism genotypes showed that risk decreased with an increasing number of C alleles (P= .01). The CC (low secreting) genotype was associated with a decreased risk of young adult Hodgkin lymphoma relative to the GG (high secreting) genotype (odds ratio [OR] = .29;P= .03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma. (Blood. 2004;103:3216-3221)</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2003-08-2860</identifier><identifier>PMID: 15070705</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Base Sequence ; Biological and medical sciences ; Case-Control Studies ; Diseases in Twins - genetics ; DNA, Complementary - genetics ; Female ; Genotype ; Hematologic and hematopoietic diseases ; Hodgkin Disease - blood ; Hodgkin Disease - genetics ; Hodgkin Disease - immunology ; Humans ; Interleukin-6 - blood ; Interleukin-6 - genetics ; Interleukin-6 - metabolism ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Genetic ; Risk Factors ; Twins, Dizygotic ; Twins, Monozygotic</subject><ispartof>Blood, 2004-04, Vol.103 (8), p.3216-3221</ispartof><rights>2004 American Society of Hematology</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-e25a7f3cff565c4ea6691a0aed0c55534bf69e825888dc8fbbb5a2157ebe55ef3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15806304$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15070705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cozen, Wendy</creatorcontrib><creatorcontrib>Gill, Parkash S.</creatorcontrib><creatorcontrib>Ingles, Sue Ann</creatorcontrib><creatorcontrib>Masood, Rizwan</creatorcontrib><creatorcontrib>Martínez-Maza, Otoniel</creatorcontrib><creatorcontrib>Cockburn, Myles G.</creatorcontrib><creatorcontrib>Gauderman, W. James</creatorcontrib><creatorcontrib>Pike, Malcolm C.</creatorcontrib><creatorcontrib>Bernstein, Leslie</creatorcontrib><creatorcontrib>Nathwani, Bharat N.</creatorcontrib><creatorcontrib>Salam, Muhammad T.</creatorcontrib><creatorcontrib>Danley, Kathleen Lackerdas</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Gage, Julia</creatorcontrib><creatorcontrib>Gundell-Miller, Susan</creatorcontrib><creatorcontrib>Mack, Thomas M.</creatorcontrib><title>IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma</title><title>Blood</title><addtitle>Blood</addtitle><description>Identical twins of young adult Hodgkin lymphoma case subjects are much more likely to develop the disease compared with fraternal twins of case subjects, suggesting a genetic determinant. Interleukin 6 (IL-6) levels are increased in patients with Hodgkin lymphoma and are correlated with a poor prognosis. We hypothesized that a heritable abnormality in IL-6 regulation may predispose to young adult Hodgkin lymphoma. We obtained blood specimens from 88 young adult Hodgkin lymphoma case subjects and their twins as well as from 87 matched control subjects. IL-6 was measured from unstimulated peripheral blood mononuclear cell (PBMC) supernatant with enzyme-linked immunosorbent assays (ELISAs) and compared by using analysis of covariance. Unaffected identical twins of case subjects (surrogate case subjects) had a 87.8% higher IL-6 level compared with matched control subjects (mean difference, +483.7 pg/mL,P= .04). Analysis of the IL-6 174G>C promoter polymorphism genotypes showed that risk decreased with an increasing number of C alleles (P= .01). The CC (low secreting) genotype was associated with a decreased risk of young adult Hodgkin lymphoma relative to the GG (high secreting) genotype (odds ratio [OR] = .29;P= .03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma. (Blood. 2004;103:3216-3221)</description><subject>Adolescent</subject><subject>Adult</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Diseases in Twins - genetics</subject><subject>DNA, Complementary - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hodgkin Disease - blood</subject><subject>Hodgkin Disease - genetics</subject><subject>Hodgkin Disease - immunology</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - genetics</subject><subject>Interleukin-6 - metabolism</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><subject>Twins, Dizygotic</subject><subject>Twins, Monozygotic</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpaDZJ_0APRZf2pnQkW7YWeimh-YCFUmjOQpZGGzWytZHshP338WYXklMYhrk878vwEPKFwznnSvzoYkqOCYCKgWJCNfCBLLgUigEI-EgWANCwetnyY3JSyn8AXldCfiLHXEI7j1yQvzcr1tCIjxgLNYOjaxzSuN0gNXneUpINZkRHn8J4R3Mo9zR5uk3TsKbGTXGk18mt78NA47bf3KXenJEjb2LBz4d7Sm4vf_-7uGarP1c3F79WzFaqHhkKaVpfWe9lI22NpmmW3IBBB1ZKWdWdb5aohFRKOat813XSCC5b7FBK9NUp-b7v3eT0MGEZdR-KxRjNgGkquuWKi6VqZ1DsQZtTKRm93uTQm7zVHPROpH4RqXciNSi9EzmHvh7ap65H9xo5mJuBbwfAFGuiz2awobzhFDQV1DP3c8_NgvExYNbFBhwsupDRjtql8N4fz64NkVk</recordid><startdate>20040415</startdate><enddate>20040415</enddate><creator>Cozen, Wendy</creator><creator>Gill, Parkash S.</creator><creator>Ingles, Sue Ann</creator><creator>Masood, Rizwan</creator><creator>Martínez-Maza, Otoniel</creator><creator>Cockburn, Myles G.</creator><creator>Gauderman, W. James</creator><creator>Pike, Malcolm C.</creator><creator>Bernstein, Leslie</creator><creator>Nathwani, Bharat N.</creator><creator>Salam, Muhammad T.</creator><creator>Danley, Kathleen Lackerdas</creator><creator>Wang, Wei</creator><creator>Gage, Julia</creator><creator>Gundell-Miller, Susan</creator><creator>Mack, Thomas M.</creator><general>Elsevier Inc</general><general>The Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040415</creationdate><title>IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma</title><author>Cozen, Wendy ; Gill, Parkash S. ; Ingles, Sue Ann ; Masood, Rizwan ; Martínez-Maza, Otoniel ; Cockburn, Myles G. ; Gauderman, W. James ; Pike, Malcolm C. ; Bernstein, Leslie ; Nathwani, Bharat N. ; Salam, Muhammad T. ; Danley, Kathleen Lackerdas ; Wang, Wei ; Gage, Julia ; Gundell-Miller, Susan ; Mack, Thomas M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-e25a7f3cff565c4ea6691a0aed0c55534bf69e825888dc8fbbb5a2157ebe55ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Diseases in Twins - genetics</topic><topic>DNA, Complementary - genetics</topic><topic>Female</topic><topic>Genotype</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hodgkin Disease - blood</topic><topic>Hodgkin Disease - genetics</topic><topic>Hodgkin Disease - immunology</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - genetics</topic><topic>Interleukin-6 - metabolism</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><topic>Twins, Dizygotic</topic><topic>Twins, Monozygotic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cozen, Wendy</creatorcontrib><creatorcontrib>Gill, Parkash S.</creatorcontrib><creatorcontrib>Ingles, Sue Ann</creatorcontrib><creatorcontrib>Masood, Rizwan</creatorcontrib><creatorcontrib>Martínez-Maza, Otoniel</creatorcontrib><creatorcontrib>Cockburn, Myles G.</creatorcontrib><creatorcontrib>Gauderman, W. James</creatorcontrib><creatorcontrib>Pike, Malcolm C.</creatorcontrib><creatorcontrib>Bernstein, Leslie</creatorcontrib><creatorcontrib>Nathwani, Bharat N.</creatorcontrib><creatorcontrib>Salam, Muhammad T.</creatorcontrib><creatorcontrib>Danley, Kathleen Lackerdas</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Gage, Julia</creatorcontrib><creatorcontrib>Gundell-Miller, Susan</creatorcontrib><creatorcontrib>Mack, Thomas M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cozen, Wendy</au><au>Gill, Parkash S.</au><au>Ingles, Sue Ann</au><au>Masood, Rizwan</au><au>Martínez-Maza, Otoniel</au><au>Cockburn, Myles G.</au><au>Gauderman, W. James</au><au>Pike, Malcolm C.</au><au>Bernstein, Leslie</au><au>Nathwani, Bharat N.</au><au>Salam, Muhammad T.</au><au>Danley, Kathleen Lackerdas</au><au>Wang, Wei</au><au>Gage, Julia</au><au>Gundell-Miller, Susan</au><au>Mack, Thomas M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2004-04-15</date><risdate>2004</risdate><volume>103</volume><issue>8</issue><spage>3216</spage><epage>3221</epage><pages>3216-3221</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Identical twins of young adult Hodgkin lymphoma case subjects are much more likely to develop the disease compared with fraternal twins of case subjects, suggesting a genetic determinant. Interleukin 6 (IL-6) levels are increased in patients with Hodgkin lymphoma and are correlated with a poor prognosis. We hypothesized that a heritable abnormality in IL-6 regulation may predispose to young adult Hodgkin lymphoma. We obtained blood specimens from 88 young adult Hodgkin lymphoma case subjects and their twins as well as from 87 matched control subjects. IL-6 was measured from unstimulated peripheral blood mononuclear cell (PBMC) supernatant with enzyme-linked immunosorbent assays (ELISAs) and compared by using analysis of covariance. Unaffected identical twins of case subjects (surrogate case subjects) had a 87.8% higher IL-6 level compared with matched control subjects (mean difference, +483.7 pg/mL,P= .04). Analysis of the IL-6 174G>C promoter polymorphism genotypes showed that risk decreased with an increasing number of C alleles (P= .01). The CC (low secreting) genotype was associated with a decreased risk of young adult Hodgkin lymphoma relative to the GG (high secreting) genotype (odds ratio [OR] = .29;P= .03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma. (Blood. 2004;103:3216-3221)</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>15070705</pmid><doi>10.1182/blood-2003-08-2860</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Base Sequence Biological and medical sciences Case-Control Studies Diseases in Twins - genetics DNA, Complementary - genetics Female Genotype Hematologic and hematopoietic diseases Hodgkin Disease - blood Hodgkin Disease - genetics Hodgkin Disease - immunology Humans Interleukin-6 - blood Interleukin-6 - genetics Interleukin-6 - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Polymorphism, Genetic Risk Factors Twins, Dizygotic Twins, Monozygotic |
| title | IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma |
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