Association between congenital cardiovascular malformations and neuroblastoma
We explored the association between neuroblastoma and congenital cardiovascular malformations (CCM), previously described in case reports. Echocardiogram and chart reviews of a series of 158 patients with neuroblastoma and a control group of 192 children with leukemia were performed. The proportion...
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| Veröffentlicht in: | The Journal of pediatrics 2004-04, Vol.144 (4), p.444-448 |
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| creator | George, Rani E. Lipshultz, Steven E. Lipsitz, Stuart R. Colan, Steven D. Diller, Lisa |
| description | We explored the association between neuroblastoma and congenital cardiovascular malformations (CCM), previously described in case reports.
Echocardiogram and chart reviews of a series of 158 patients with neuroblastoma and a control group of 192 children with leukemia were performed. The proportion of patients with CCM in each group was compared.
Fourteen of the 70 (20%) patients with neuroblastoma and echocardiography had CCM, compared with 7 of the 192 (3.6%) patients with leukemia with echocardiograms (
P
=
.0001). If all of the patients with neuroblastoma without echocardiograms (n
=
88) are considered to have normal cardiac anatomy, this difference remains significant (14 of 158 patients with neuroblastoma have CCM detected [8.9%] versus 7 of 192 patients with leukemia [3.6%];
P
=
.045). Neural crest–derived CCM were more common in patients with neuroblastoma, detected in 5 of 70 patients with neuroblastoma versus 2 of 192 patients with leukemia (
P
=
.016). Congenital cardiovascular malformations in patients with neuroblastoma were associated with a cancer diagnosis at age less than 1 year and a lower neuroblastoma stage, but there was no association with tumor
MYCN amplification.
Neuroblastoma and CCM may be associated. We recommend echocardiography for CCM screening in patients with newly diagnosed neuroblastoma. |
| doi_str_mv | 10.1016/j.jpeds.2003.12.032 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71812386</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347604000150</els_id><sourcerecordid>71812386</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-58945643d24535e3c6af29868f3c4ec076bac04839f89ead81ffad12e219824f3</originalsourceid><addsrcrecordid>eNp90D1rHDEQgGFhEuKzk18QCNvE3a5HH6uTChfGxB9gkyaphU4aGR270kXatcm_z9p3EFeupnlmGF5CvlLoKFB5vu22O_S1YwC8o6wDzo7IioJet1Jx_oGsABhruVjLY3JS6xYAtAD4RI5pD1JzDSvycFlrdtFOMadmg9MzYmpcTo-Y4mSHxtniY36y1c2DLc1oh5DL-MprY5NvEs4lbwZbpzzaz-RjsEPFL4d5Sn5f__h1ddve_7y5u7q8b53o6dT2SoteCu6Z6HmP3EkbmFZSBe4EOljLjXUgFNdBabRe0RCspwwZ1YqJwE_J2f7uruQ_M9bJjLE6HAabMM_VrKmijCu5QL6HruRaCwazK3G05a-hYF4qmq15rWheKhrKzFJx2fp2OD9vRvT_dw7ZFvD9AJYwS5Jik4v1jZOSQ88Xd7F3uMR4ilhMdRGTQx8Lusn4HN995B_bIpIp</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71812386</pqid></control><display><type>article</type><title>Association between congenital cardiovascular malformations and neuroblastoma</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>George, Rani E. ; Lipshultz, Steven E. ; Lipsitz, Stuart R. ; Colan, Steven D. ; Diller, Lisa</creator><creatorcontrib>George, Rani E. ; Lipshultz, Steven E. ; Lipsitz, Stuart R. ; Colan, Steven D. ; Diller, Lisa</creatorcontrib><description>We explored the association between neuroblastoma and congenital cardiovascular malformations (CCM), previously described in case reports.
Echocardiogram and chart reviews of a series of 158 patients with neuroblastoma and a control group of 192 children with leukemia were performed. The proportion of patients with CCM in each group was compared.
Fourteen of the 70 (20%) patients with neuroblastoma and echocardiography had CCM, compared with 7 of the 192 (3.6%) patients with leukemia with echocardiograms (
P
=
.0001). If all of the patients with neuroblastoma without echocardiograms (n
=
88) are considered to have normal cardiac anatomy, this difference remains significant (14 of 158 patients with neuroblastoma have CCM detected [8.9%] versus 7 of 192 patients with leukemia [3.6%];
P
=
.045). Neural crest–derived CCM were more common in patients with neuroblastoma, detected in 5 of 70 patients with neuroblastoma versus 2 of 192 patients with leukemia (
P
=
.016). Congenital cardiovascular malformations in patients with neuroblastoma were associated with a cancer diagnosis at age less than 1 year and a lower neuroblastoma stage, but there was no association with tumor
MYCN amplification.
Neuroblastoma and CCM may be associated. We recommend echocardiography for CCM screening in patients with newly diagnosed neuroblastoma.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2003.12.032</identifier><identifier>PMID: 15069390</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Acute lymphoblastic leukemia ; Adolescent ; Age Distribution ; ALL ; Biological and medical sciences ; Case-Control Studies ; CCM ; Child ; Child, Preschool ; Congenital cardiovascular malformations ; Echocardiography ; Female ; Heart Defects, Congenital - complications ; Heart Defects, Congenital - epidemiology ; Humans ; Infant ; Infant, Newborn ; Medical sciences ; Neuroblastoma ; Neuroblastoma - complications ; Neuroblastoma - epidemiology ; Neuroblastoma - pathology ; Neurology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology ; Pregnancy ; Prevalence ; Tumors of the nervous system. Phacomatoses ; United States - epidemiology</subject><ispartof>The Journal of pediatrics, 2004-04, Vol.144 (4), p.444-448</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-58945643d24535e3c6af29868f3c4ec076bac04839f89ead81ffad12e219824f3</citedby><cites>FETCH-LOGICAL-c451t-58945643d24535e3c6af29868f3c4ec076bac04839f89ead81ffad12e219824f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347604000150$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15663053$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15069390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>George, Rani E.</creatorcontrib><creatorcontrib>Lipshultz, Steven E.</creatorcontrib><creatorcontrib>Lipsitz, Stuart R.</creatorcontrib><creatorcontrib>Colan, Steven D.</creatorcontrib><creatorcontrib>Diller, Lisa</creatorcontrib><title>Association between congenital cardiovascular malformations and neuroblastoma</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>We explored the association between neuroblastoma and congenital cardiovascular malformations (CCM), previously described in case reports.
Echocardiogram and chart reviews of a series of 158 patients with neuroblastoma and a control group of 192 children with leukemia were performed. The proportion of patients with CCM in each group was compared.
Fourteen of the 70 (20%) patients with neuroblastoma and echocardiography had CCM, compared with 7 of the 192 (3.6%) patients with leukemia with echocardiograms (
P
=
.0001). If all of the patients with neuroblastoma without echocardiograms (n
=
88) are considered to have normal cardiac anatomy, this difference remains significant (14 of 158 patients with neuroblastoma have CCM detected [8.9%] versus 7 of 192 patients with leukemia [3.6%];
P
=
.045). Neural crest–derived CCM were more common in patients with neuroblastoma, detected in 5 of 70 patients with neuroblastoma versus 2 of 192 patients with leukemia (
P
=
.016). Congenital cardiovascular malformations in patients with neuroblastoma were associated with a cancer diagnosis at age less than 1 year and a lower neuroblastoma stage, but there was no association with tumor
MYCN amplification.
Neuroblastoma and CCM may be associated. We recommend echocardiography for CCM screening in patients with newly diagnosed neuroblastoma.</description><subject>Acute lymphoblastic leukemia</subject><subject>Adolescent</subject><subject>Age Distribution</subject><subject>ALL</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>CCM</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Congenital cardiovascular malformations</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart Defects, Congenital - complications</subject><subject>Heart Defects, Congenital - epidemiology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Medical sciences</subject><subject>Neuroblastoma</subject><subject>Neuroblastoma - complications</subject><subject>Neuroblastoma - epidemiology</subject><subject>Neuroblastoma - pathology</subject><subject>Neurology</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology</subject><subject>Pregnancy</subject><subject>Prevalence</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>United States - epidemiology</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90D1rHDEQgGFhEuKzk18QCNvE3a5HH6uTChfGxB9gkyaphU4aGR270kXatcm_z9p3EFeupnlmGF5CvlLoKFB5vu22O_S1YwC8o6wDzo7IioJet1Jx_oGsABhruVjLY3JS6xYAtAD4RI5pD1JzDSvycFlrdtFOMadmg9MzYmpcTo-Y4mSHxtniY36y1c2DLc1oh5DL-MprY5NvEs4lbwZbpzzaz-RjsEPFL4d5Sn5f__h1ddve_7y5u7q8b53o6dT2SoteCu6Z6HmP3EkbmFZSBe4EOljLjXUgFNdBabRe0RCspwwZ1YqJwE_J2f7uruQ_M9bJjLE6HAabMM_VrKmijCu5QL6HruRaCwazK3G05a-hYF4qmq15rWheKhrKzFJx2fp2OD9vRvT_dw7ZFvD9AJYwS5Jik4v1jZOSQ88Xd7F3uMR4ilhMdRGTQx8Lusn4HN995B_bIpIp</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>George, Rani E.</creator><creator>Lipshultz, Steven E.</creator><creator>Lipsitz, Stuart R.</creator><creator>Colan, Steven D.</creator><creator>Diller, Lisa</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040401</creationdate><title>Association between congenital cardiovascular malformations and neuroblastoma</title><author>George, Rani E. ; Lipshultz, Steven E. ; Lipsitz, Stuart R. ; Colan, Steven D. ; Diller, Lisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-58945643d24535e3c6af29868f3c4ec076bac04839f89ead81ffad12e219824f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>Adolescent</topic><topic>Age Distribution</topic><topic>ALL</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>CCM</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Congenital cardiovascular malformations</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Heart Defects, Congenital - complications</topic><topic>Heart Defects, Congenital - epidemiology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Medical sciences</topic><topic>Neuroblastoma</topic><topic>Neuroblastoma - complications</topic><topic>Neuroblastoma - epidemiology</topic><topic>Neuroblastoma - pathology</topic><topic>Neurology</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology</topic><topic>Pregnancy</topic><topic>Prevalence</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>George, Rani E.</creatorcontrib><creatorcontrib>Lipshultz, Steven E.</creatorcontrib><creatorcontrib>Lipsitz, Stuart R.</creatorcontrib><creatorcontrib>Colan, Steven D.</creatorcontrib><creatorcontrib>Diller, Lisa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>George, Rani E.</au><au>Lipshultz, Steven E.</au><au>Lipsitz, Stuart R.</au><au>Colan, Steven D.</au><au>Diller, Lisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between congenital cardiovascular malformations and neuroblastoma</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>144</volume><issue>4</issue><spage>444</spage><epage>448</epage><pages>444-448</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>We explored the association between neuroblastoma and congenital cardiovascular malformations (CCM), previously described in case reports.
Echocardiogram and chart reviews of a series of 158 patients with neuroblastoma and a control group of 192 children with leukemia were performed. The proportion of patients with CCM in each group was compared.
Fourteen of the 70 (20%) patients with neuroblastoma and echocardiography had CCM, compared with 7 of the 192 (3.6%) patients with leukemia with echocardiograms (
P
=
.0001). If all of the patients with neuroblastoma without echocardiograms (n
=
88) are considered to have normal cardiac anatomy, this difference remains significant (14 of 158 patients with neuroblastoma have CCM detected [8.9%] versus 7 of 192 patients with leukemia [3.6%];
P
=
.045). Neural crest–derived CCM were more common in patients with neuroblastoma, detected in 5 of 70 patients with neuroblastoma versus 2 of 192 patients with leukemia (
P
=
.016). Congenital cardiovascular malformations in patients with neuroblastoma were associated with a cancer diagnosis at age less than 1 year and a lower neuroblastoma stage, but there was no association with tumor
MYCN amplification.
Neuroblastoma and CCM may be associated. We recommend echocardiography for CCM screening in patients with newly diagnosed neuroblastoma.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>15069390</pmid><doi>10.1016/j.jpeds.2003.12.032</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute lymphoblastic leukemia Adolescent Age Distribution ALL Biological and medical sciences Case-Control Studies CCM Child Child, Preschool Congenital cardiovascular malformations Echocardiography Female Heart Defects, Congenital - complications Heart Defects, Congenital - epidemiology Humans Infant Infant, Newborn Medical sciences Neuroblastoma Neuroblastoma - complications Neuroblastoma - epidemiology Neuroblastoma - pathology Neurology Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology Pregnancy Prevalence Tumors of the nervous system. Phacomatoses United States - epidemiology |
| title | Association between congenital cardiovascular malformations and neuroblastoma |
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