Impact of Topoisomerase II alpha and Spermine on the clinical outcome of children with acute lymphoblastic leukemia

It has been reported in the literature that a leukemic cell may be (or become) resistant to anti-cancer treatment because many mechanisms, such as efflux membrane pump (multi-drug resistance, MDR-P170), intracellular transport (LRP, MRP), or different detoxification systems (glutathione transferases...

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Veröffentlicht in:	Leukemia research 2004-05, Vol.28 (5), p.479-486
Hauptverfasser:	Grandgirard, Nathalie, Ly-Sunnaram, Beatrice, Ferrant, Dominique, Gandemer, Virginie, Edan, Christine, Le Gall, Edouard, Moulinoux, Jacques-Phillipe, Leray, Emmanuelle, Goasguen, Jean E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Antigens, Neoplasm Child Cytoplasm - chemistry Disease-Free Survival DNA Topoisomerases, Type II - analysis DNA-Binding Proteins Drug Resistance, Neoplasm Humans Immunohistochemistry Multidrug resistance Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Prognosis Retrospective Studies Spermine Spermine - analysis Topoisomerase
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