Adhesion of Lactic Acid Bacteria to Caco-2 Cells and Their Effect on Cytokine Secretion
Cytokines secreted by human enterocytes play a critical role in mucosal and systemic immunity. Intestinal microorganisms can influence this secretion. In the present study, 30 strains of lactic acid bacteria were characterized for their adhesion to Caco‐2 cells and their potential to stimulate proin...
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| Veröffentlicht in: | Microbiology and immunology 2002-01, Vol.46 (4), p.293-297 |
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| container_title | Microbiology and immunology |
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| creator | Morita, Hirotsugu He, Fang Fuse, Tetsuo Ouwehand, Arthur C. Hashimoto, Hideo Hosoda, Masataka Mizumachi, Koko Kurisaki, Jun-ichi |
| description | Cytokines secreted by human enterocytes play a critical role in mucosal and systemic immunity. Intestinal microorganisms can influence this secretion. In the present study, 30 strains of lactic acid bacteria were characterized for their adhesion to Caco‐2 cells and their potential to stimulate proinflammatory cytokine secretion by this cell line. The bacteria adhered in a strain‐dependent manner to Caco‐2 cells. Contact with lactobacilli did not result in the production of IL‐6 or IL‐8. A slight IL‐6 and IL‐8 production by a Caco‐2 cell was detected after exposure to 8 of the tested Bifidobacterium strains. No correlation was found between adhesion and cytokine induction among the bacteria tested. This indicates that lactic acid bacteria, even those with strong adhesive properties, are not very likely to trigger an inflammatory response in human enterocytes. |
| doi_str_mv | 10.1111/j.1348-0421.2002.tb02698.x |
| format | Article |
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Intestinal microorganisms can influence this secretion. In the present study, 30 strains of lactic acid bacteria were characterized for their adhesion to Caco‐2 cells and their potential to stimulate proinflammatory cytokine secretion by this cell line. The bacteria adhered in a strain‐dependent manner to Caco‐2 cells. Contact with lactobacilli did not result in the production of IL‐6 or IL‐8. A slight IL‐6 and IL‐8 production by a Caco‐2 cell was detected after exposure to 8 of the tested Bifidobacterium strains. No correlation was found between adhesion and cytokine induction among the bacteria tested. This indicates that lactic acid bacteria, even those with strong adhesive properties, are not very likely to trigger an inflammatory response in human enterocytes.</description><identifier>ISSN: 0385-5600</identifier><identifier>EISSN: 1348-0421</identifier><identifier>DOI: 10.1111/j.1348-0421.2002.tb02698.x</identifier><identifier>PMID: 12061632</identifier><identifier>CODEN: MIIMDV</identifier><language>eng</language><publisher>Tokyo: Blackwell Publishing Ltd</publisher><subject>Adult ; Bacterial Adhesion - physiology ; Bifidobacterium ; Biological and medical sciences ; Caco-2 Cells ; cytokine ; Cytokines - metabolism ; Enterocytes - metabolism ; Enterocytes - microbiology ; Food industries ; Fundamental and applied biological sciences. Psychology ; Humans ; Infant ; interleukin 6 ; interleukin 8 ; Interleukin-6 - biosynthesis ; Interleukin-6 - metabolism ; Interleukin-8 - biosynthesis ; Interleukin-8 - metabolism ; lactic acid bacteria ; Lactobacillus - physiology ; probiotics ; Research and development. New food products, dietetic foods and beverages</subject><ispartof>Microbiology and immunology, 2002-01, Vol.46 (4), p.293-297</ispartof><rights>owned by Center for Academic Publications Japan (Publisher)</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5478-bfcc24fad2fa819c4a9f6a6f118d72b807f4e3a7b9e57e3a83067c957e45b5533</citedby><cites>FETCH-LOGICAL-c5478-bfcc24fad2fa819c4a9f6a6f118d72b807f4e3a7b9e57e3a83067c957e45b5533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1348-0421.2002.tb02698.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1348-0421.2002.tb02698.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13685043$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12061632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morita, Hirotsugu</creatorcontrib><creatorcontrib>He, Fang</creatorcontrib><creatorcontrib>Fuse, Tetsuo</creatorcontrib><creatorcontrib>Ouwehand, Arthur C.</creatorcontrib><creatorcontrib>Hashimoto, Hideo</creatorcontrib><creatorcontrib>Hosoda, Masataka</creatorcontrib><creatorcontrib>Mizumachi, Koko</creatorcontrib><creatorcontrib>Kurisaki, Jun-ichi</creatorcontrib><title>Adhesion of Lactic Acid Bacteria to Caco-2 Cells and Their Effect on Cytokine Secretion</title><title>Microbiology and immunology</title><addtitle>Microbiology and Immunology</addtitle><description>Cytokines secreted by human enterocytes play a critical role in mucosal and systemic immunity. Intestinal microorganisms can influence this secretion. In the present study, 30 strains of lactic acid bacteria were characterized for their adhesion to Caco‐2 cells and their potential to stimulate proinflammatory cytokine secretion by this cell line. The bacteria adhered in a strain‐dependent manner to Caco‐2 cells. Contact with lactobacilli did not result in the production of IL‐6 or IL‐8. A slight IL‐6 and IL‐8 production by a Caco‐2 cell was detected after exposure to 8 of the tested Bifidobacterium strains. No correlation was found between adhesion and cytokine induction among the bacteria tested. This indicates that lactic acid bacteria, even those with strong adhesive properties, are not very likely to trigger an inflammatory response in human enterocytes.</description><subject>Adult</subject><subject>Bacterial Adhesion - physiology</subject><subject>Bifidobacterium</subject><subject>Biological and medical sciences</subject><subject>Caco-2 Cells</subject><subject>cytokine</subject><subject>Cytokines - metabolism</subject><subject>Enterocytes - metabolism</subject><subject>Enterocytes - microbiology</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infant</subject><subject>interleukin 6</subject><subject>interleukin 8</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Interleukin-6 - metabolism</subject><subject>Interleukin-8 - biosynthesis</subject><subject>Interleukin-8 - metabolism</subject><subject>lactic acid bacteria</subject><subject>Lactobacillus - physiology</subject><subject>probiotics</subject><subject>Research and development. 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Psychology</topic><topic>Humans</topic><topic>Infant</topic><topic>interleukin 6</topic><topic>interleukin 8</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Interleukin-6 - metabolism</topic><topic>Interleukin-8 - biosynthesis</topic><topic>Interleukin-8 - metabolism</topic><topic>lactic acid bacteria</topic><topic>Lactobacillus - physiology</topic><topic>probiotics</topic><topic>Research and development. New food products, dietetic foods and beverages</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morita, Hirotsugu</creatorcontrib><creatorcontrib>He, Fang</creatorcontrib><creatorcontrib>Fuse, Tetsuo</creatorcontrib><creatorcontrib>Ouwehand, Arthur C.</creatorcontrib><creatorcontrib>Hashimoto, Hideo</creatorcontrib><creatorcontrib>Hosoda, Masataka</creatorcontrib><creatorcontrib>Mizumachi, Koko</creatorcontrib><creatorcontrib>Kurisaki, Jun-ichi</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Microbiology and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morita, Hirotsugu</au><au>He, Fang</au><au>Fuse, Tetsuo</au><au>Ouwehand, Arthur C.</au><au>Hashimoto, Hideo</au><au>Hosoda, Masataka</au><au>Mizumachi, Koko</au><au>Kurisaki, Jun-ichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adhesion of Lactic Acid Bacteria to Caco-2 Cells and Their Effect on Cytokine Secretion</atitle><jtitle>Microbiology and immunology</jtitle><addtitle>Microbiology and Immunology</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>46</volume><issue>4</issue><spage>293</spage><epage>297</epage><pages>293-297</pages><issn>0385-5600</issn><eissn>1348-0421</eissn><coden>MIIMDV</coden><abstract>Cytokines secreted by human enterocytes play a critical role in mucosal and systemic immunity. Intestinal microorganisms can influence this secretion. In the present study, 30 strains of lactic acid bacteria were characterized for their adhesion to Caco‐2 cells and their potential to stimulate proinflammatory cytokine secretion by this cell line. The bacteria adhered in a strain‐dependent manner to Caco‐2 cells. Contact with lactobacilli did not result in the production of IL‐6 or IL‐8. A slight IL‐6 and IL‐8 production by a Caco‐2 cell was detected after exposure to 8 of the tested Bifidobacterium strains. No correlation was found between adhesion and cytokine induction among the bacteria tested. This indicates that lactic acid bacteria, even those with strong adhesive properties, are not very likely to trigger an inflammatory response in human enterocytes.</abstract><cop>Tokyo</cop><pub>Blackwell Publishing Ltd</pub><pmid>12061632</pmid><doi>10.1111/j.1348-0421.2002.tb02698.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Bacterial Adhesion - physiology Bifidobacterium Biological and medical sciences Caco-2 Cells cytokine Cytokines - metabolism Enterocytes - metabolism Enterocytes - microbiology Food industries Fundamental and applied biological sciences. Psychology Humans Infant interleukin 6 interleukin 8 Interleukin-6 - biosynthesis Interleukin-6 - metabolism Interleukin-8 - biosynthesis Interleukin-8 - metabolism lactic acid bacteria Lactobacillus - physiology probiotics Research and development. New food products, dietetic foods and beverages |
| title | Adhesion of Lactic Acid Bacteria to Caco-2 Cells and Their Effect on Cytokine Secretion |
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