The Evolution of Airway Function in Early Childhood Following Clinical Diagnosis of Cystic Fibrosis
This study aimed to investigate the evolution of airway function in infants newly diagnosed with cystic fibrosis (CF). FEV(0.5) was measured soon after diagnosis (median age of 28 weeks) and 6 months later in subjects with CF and on two occasions 6 months apart (median ages of 7.4 and 33.7 weeks) in...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2004-04, Vol.169 (8), p.928-933 |
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| creator | Ranganathan, Sarath C Stocks, Janet Dezateux, Carol Bush, Andrew Wade, Angie Carr, Siobhan Castle, Rosemary Dinwiddie, Robert Hoo, Ah-Fong Lum, Sooky Price, John Stroobant, John Wallis, Colin |
| description | This study aimed to investigate the evolution of airway function in infants newly diagnosed with cystic fibrosis (CF). FEV(0.5) was measured soon after diagnosis (median age of 28 weeks) and 6 months later in subjects with CF and on two occasions 6 months apart (median ages of 7.4 and 33.7 weeks) in healthy infants, using the raised-volume technique. Repeated measurements were successful in 34 CF and 32 healthy subjects. After adjustment for age, length, sex, and exposure to maternal smoking, mean FEV(0.5) was significantly lower in infants with CF both shortly after diagnosis and at the second test, with no significant difference in rate of increase in FEV(0.5) with growth between the two groups. When compared with published reference data, FEV(0.5) was reduced by an average of two z scores on both test occasions in those with CF, with 72% of individuals having an FEV(0.5) of less than 1.64 z-scores (i.e., less than the fifth percentile) on one or both test occasions. On longitudinal analysis, subjects with CF experienced a mean (95% confidence interval) reduction in FEV(0.5) of 20% (11, 28). Airway function is diminished soon after diagnosis in infants with CF and does not catch up during infancy and early childhood. These findings have important implications for early interventions in CF. |
| doi_str_mv | 10.1164/rccm.200309-1344OC |
| format | Article |
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FEV(0.5) was measured soon after diagnosis (median age of 28 weeks) and 6 months later in subjects with CF and on two occasions 6 months apart (median ages of 7.4 and 33.7 weeks) in healthy infants, using the raised-volume technique. Repeated measurements were successful in 34 CF and 32 healthy subjects. After adjustment for age, length, sex, and exposure to maternal smoking, mean FEV(0.5) was significantly lower in infants with CF both shortly after diagnosis and at the second test, with no significant difference in rate of increase in FEV(0.5) with growth between the two groups. When compared with published reference data, FEV(0.5) was reduced by an average of two z scores on both test occasions in those with CF, with 72% of individuals having an FEV(0.5) of less than 1.64 z-scores (i.e., less than the fifth percentile) on one or both test occasions. On longitudinal analysis, subjects with CF experienced a mean (95% confidence interval) reduction in FEV(0.5) of 20% (11, 28). Airway function is diminished soon after diagnosis in infants with CF and does not catch up during infancy and early childhood. These findings have important implications for early interventions in CF.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.200309-1344OC</identifier><identifier>PMID: 14754763</identifier><language>eng</language><publisher>New York, NY: Am Thoracic Soc</publisher><subject>Age ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Body Height ; Body Weight ; Case-Control Studies ; Child ; Child Development - physiology ; Child, Preschool ; Cohort Studies ; Cystic fibrosis ; Cystic Fibrosis - diagnosis ; Cystic Fibrosis - physiopathology ; Cystic Fibrosis - therapy ; Female ; Forced Expiratory Volume ; Humans ; Infant ; Intensive care medicine ; Longitudinal studies ; Lung - physiopathology ; Male ; Medical sciences ; Medical screening ; Research ethics</subject><ispartof>American journal of respiratory and critical care medicine, 2004-04, Vol.169 (8), p.928-933</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Thoracic Society Apr 15, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-90c12bd6c8074d1ed9d870df9daf1345bdb616438402f368b7150b7f768fc9b73</citedby><cites>FETCH-LOGICAL-c458t-90c12bd6c8074d1ed9d870df9daf1345bdb616438402f368b7150b7f768fc9b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4011,4012,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15608388$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14754763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ranganathan, Sarath C</creatorcontrib><creatorcontrib>Stocks, Janet</creatorcontrib><creatorcontrib>Dezateux, Carol</creatorcontrib><creatorcontrib>Bush, Andrew</creatorcontrib><creatorcontrib>Wade, Angie</creatorcontrib><creatorcontrib>Carr, Siobhan</creatorcontrib><creatorcontrib>Castle, Rosemary</creatorcontrib><creatorcontrib>Dinwiddie, Robert</creatorcontrib><creatorcontrib>Hoo, Ah-Fong</creatorcontrib><creatorcontrib>Lum, Sooky</creatorcontrib><creatorcontrib>Price, John</creatorcontrib><creatorcontrib>Stroobant, John</creatorcontrib><creatorcontrib>Wallis, Colin</creatorcontrib><title>The Evolution of Airway Function in Early Childhood Following Clinical Diagnosis of Cystic Fibrosis</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>This study aimed to investigate the evolution of airway function in infants newly diagnosed with cystic fibrosis (CF). FEV(0.5) was measured soon after diagnosis (median age of 28 weeks) and 6 months later in subjects with CF and on two occasions 6 months apart (median ages of 7.4 and 33.7 weeks) in healthy infants, using the raised-volume technique. Repeated measurements were successful in 34 CF and 32 healthy subjects. After adjustment for age, length, sex, and exposure to maternal smoking, mean FEV(0.5) was significantly lower in infants with CF both shortly after diagnosis and at the second test, with no significant difference in rate of increase in FEV(0.5) with growth between the two groups. When compared with published reference data, FEV(0.5) was reduced by an average of two z scores on both test occasions in those with CF, with 72% of individuals having an FEV(0.5) of less than 1.64 z-scores (i.e., less than the fifth percentile) on one or both test occasions. On longitudinal analysis, subjects with CF experienced a mean (95% confidence interval) reduction in FEV(0.5) of 20% (11, 28). Airway function is diminished soon after diagnosis in infants with CF and does not catch up during infancy and early childhood. These findings have important implications for early interventions in CF.</description><subject>Age</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Body Height</subject><subject>Body Weight</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child Development - physiology</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - diagnosis</subject><subject>Cystic Fibrosis - physiopathology</subject><subject>Cystic Fibrosis - therapy</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Infant</subject><subject>Intensive care medicine</subject><subject>Longitudinal studies</subject><subject>Lung - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical screening</subject><subject>Research ethics</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkM1q3DAUhU1padK0L9BFEYUWunAqWbJ-lsGdSQuBbFLoTsj6GWuQrVQaZ5i3rxwPBLqSuHz3SOerqo8IXiNEyfek9XjdQIihqBEm5L57VV2iFrc1EQy-LnfIcE2I-HNRvct5DyFqOIJvqwtEWEsYxZeVfhgs2DzFMB98nEB04ManozqB7Tzp55GfwEalcALd4IMZYjRgG0OIRz_tQBf85LUK4IdXuylmn5eI7pQPXoOt79Myel-9cSpk--F8XlW_t5uH7md9d3_7q7u5qzVp-aEWUKOmN1RzyIhB1gjDGTROGOVKvbY3PS21MSewcZjynqEW9swxyp0WPcNX1dc19zHFv7PNBzn6rG0IarJxzpIhXrw1qICf_wP3cU5T-ZtEQrSUI7pAzQrpUiIn6-Rj8qNKJ4mgXPzLxb9c_cvVf1n6dE6e-9Gal5Wz8AJ8OQMqF28uqUn7_MK1FHLMeeG-rdzgd8PRJyvzqEIosUiq_fIyokJyKRqO_wHTpJyc</recordid><startdate>20040415</startdate><enddate>20040415</enddate><creator>Ranganathan, Sarath C</creator><creator>Stocks, Janet</creator><creator>Dezateux, Carol</creator><creator>Bush, Andrew</creator><creator>Wade, Angie</creator><creator>Carr, Siobhan</creator><creator>Castle, Rosemary</creator><creator>Dinwiddie, Robert</creator><creator>Hoo, Ah-Fong</creator><creator>Lum, Sooky</creator><creator>Price, John</creator><creator>Stroobant, John</creator><creator>Wallis, Colin</creator><general>Am Thoracic Soc</general><general>American Lung Association</general><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20040415</creationdate><title>The Evolution of Airway Function in Early Childhood Following Clinical Diagnosis of Cystic Fibrosis</title><author>Ranganathan, Sarath C ; Stocks, Janet ; Dezateux, Carol ; Bush, Andrew ; Wade, Angie ; Carr, Siobhan ; Castle, Rosemary ; Dinwiddie, Robert ; Hoo, Ah-Fong ; Lum, Sooky ; Price, John ; Stroobant, John ; Wallis, Colin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-90c12bd6c8074d1ed9d870df9daf1345bdb616438402f368b7150b7f768fc9b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Age</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Body Height</topic><topic>Body Weight</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child Development - physiology</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Cystic fibrosis</topic><topic>Cystic Fibrosis - diagnosis</topic><topic>Cystic Fibrosis - physiopathology</topic><topic>Cystic Fibrosis - therapy</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Humans</topic><topic>Infant</topic><topic>Intensive care medicine</topic><topic>Longitudinal studies</topic><topic>Lung - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medical screening</topic><topic>Research ethics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ranganathan, Sarath C</creatorcontrib><creatorcontrib>Stocks, Janet</creatorcontrib><creatorcontrib>Dezateux, Carol</creatorcontrib><creatorcontrib>Bush, Andrew</creatorcontrib><creatorcontrib>Wade, Angie</creatorcontrib><creatorcontrib>Carr, Siobhan</creatorcontrib><creatorcontrib>Castle, Rosemary</creatorcontrib><creatorcontrib>Dinwiddie, Robert</creatorcontrib><creatorcontrib>Hoo, Ah-Fong</creatorcontrib><creatorcontrib>Lum, Sooky</creatorcontrib><creatorcontrib>Price, John</creatorcontrib><creatorcontrib>Stroobant, John</creatorcontrib><creatorcontrib>Wallis, Colin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ranganathan, Sarath C</au><au>Stocks, Janet</au><au>Dezateux, Carol</au><au>Bush, Andrew</au><au>Wade, Angie</au><au>Carr, Siobhan</au><au>Castle, Rosemary</au><au>Dinwiddie, Robert</au><au>Hoo, Ah-Fong</au><au>Lum, Sooky</au><au>Price, John</au><au>Stroobant, John</au><au>Wallis, Colin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Evolution of Airway Function in Early Childhood Following Clinical Diagnosis of Cystic Fibrosis</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2004-04-15</date><risdate>2004</risdate><volume>169</volume><issue>8</issue><spage>928</spage><epage>933</epage><pages>928-933</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>This study aimed to investigate the evolution of airway function in infants newly diagnosed with cystic fibrosis (CF). FEV(0.5) was measured soon after diagnosis (median age of 28 weeks) and 6 months later in subjects with CF and on two occasions 6 months apart (median ages of 7.4 and 33.7 weeks) in healthy infants, using the raised-volume technique. Repeated measurements were successful in 34 CF and 32 healthy subjects. After adjustment for age, length, sex, and exposure to maternal smoking, mean FEV(0.5) was significantly lower in infants with CF both shortly after diagnosis and at the second test, with no significant difference in rate of increase in FEV(0.5) with growth between the two groups. When compared with published reference data, FEV(0.5) was reduced by an average of two z scores on both test occasions in those with CF, with 72% of individuals having an FEV(0.5) of less than 1.64 z-scores (i.e., less than the fifth percentile) on one or both test occasions. On longitudinal analysis, subjects with CF experienced a mean (95% confidence interval) reduction in FEV(0.5) of 20% (11, 28). Airway function is diminished soon after diagnosis in infants with CF and does not catch up during infancy and early childhood. These findings have important implications for early interventions in CF.</abstract><cop>New York, NY</cop><pub>Am Thoracic Soc</pub><pmid>14754763</pmid><doi>10.1164/rccm.200309-1344OC</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; American Thoracic Society (ATS) Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Age Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Body Height Body Weight Case-Control Studies Child Child Development - physiology Child, Preschool Cohort Studies Cystic fibrosis Cystic Fibrosis - diagnosis Cystic Fibrosis - physiopathology Cystic Fibrosis - therapy Female Forced Expiratory Volume Humans Infant Intensive care medicine Longitudinal studies Lung - physiopathology Male Medical sciences Medical screening Research ethics |
| title | The Evolution of Airway Function in Early Childhood Following Clinical Diagnosis of Cystic Fibrosis |
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