Rhythmic expression of DEC1 and DEC2 in peripheral tissues: DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP

The mammalian master molecular clock consisting of several clock gene products in the suprachiasmatic nucleus (SCN) drives circadian rhythms in behaviour and physiology. Molecular clocks consisting of the same components also exist in various peripheral organs. DEC1 and DEC2, basic helix-loop-helix...

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Veröffentlicht in:	Genes to cells : devoted to molecular & cellular mechanisms 2004-04, Vol.9 (4), p.317-329
Hauptverfasser:	Noshiro, Mitsuhide, Kawamoto, Takeshi, Furukawa, Masae, Fujimoto, Katsumi, Yoshida, Yuzo, Sasabe, Eri, Tsutsumi, Shinichi, Hamada, Taizo, Honma, Sato, Honma, Ken‐ichi, Kato, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors Cholesterol 7-alpha-Hydroxylase - metabolism Circadian Rhythm - physiology Cytochrome P-450 Enzyme System - metabolism DNA-Binding Proteins - metabolism Liver - metabolism Rats RNA, Messenger - metabolism Steroid 12-alpha-Hydroxylase - metabolism Suprachiasmatic Nucleus - metabolism Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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