Results of a Cytomegalovirus (CMV)-Specific CD8+/Interferon-γ+ Cytokine Flow Cytometry Assay Correlate with Clinical Evidence of Protective Immunity in Patients with AIDS with CMV Retinitis
To evaluate the potential clinical utility of a cytomegalovirus (CMV)-specific CD8+/interferon (IFN)-γ+ cytokine flow cytometry (CFC) assay for patients with CMV retinitis (CMVR), stored peripheral blood mononuclear cell specimens were obtained from patients with active CMVR (i.e., having clinical e...
Gespeichert in:
| Veröffentlicht in: | The Journal of infectious diseases 2004-04, Vol.189 (8), p.1362-1373 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1373 |
|---|---|
| container_issue | 8 |
| container_start_page | 1362 |
| container_title | The Journal of infectious diseases |
| container_volume | 189 |
| creator | Jacobson, Mark A. Maecker, Holden T. Orr, Patricia L. D'Amico, Ron Van Natta, Mark Li, Xiao-Dong Pollard, Richard B. Bredt, Barry M. |
| description | To evaluate the potential clinical utility of a cytomegalovirus (CMV)-specific CD8+/interferon (IFN)-γ+ cytokine flow cytometry (CFC) assay for patients with CMV retinitis (CMVR), stored peripheral blood mononuclear cell specimens were obtained from patients with active CMVR (i.e., having clinical evidence of absent CMVprotective immunity), as well as from highly active antiretroviral therapy-treated patients with CMVR who were able to discontinue anti-CMV therapy without subsequent progression of retinitis (i.e., having clinical evidence of restored CMV-protective immunity). Positive CD8+/IFN-γ+ T lymphocyte responses to CMV phosphoprotein 65 or immediate early peptide-pool stimulation were present in specimens from only 3 of 10 patients with active CMVR but were present in at least 1 specimen from all 20 patients with immunorestored CMVR, with a mean of 2.4 specimens/patient tested, spanning up to 6 months of observation (P = .0001). Among the patients with immunorestored CMVR, positive responses were present in all longitudinal specimens from 15 of the 20 patients. These data suggest that further testing of the CMV-specific CD8+/IFN-γ+ CFC assay, for clinical utility in predicting incident and progressive CMVR disease, is warranted. |
| doi_str_mv | 10.1086/382964 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_71809658</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30075952</jstor_id><oup_id>10.1086/382964</oup_id><sourcerecordid>30075952</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-47139106704dc0bf2ff309df493dd6d28e7f718c7f1644b3a289fb9f552961f53</originalsourceid><addsrcrecordid>eNp1kdFu0zAYhSMEYmXAG4AMEgg0hdlxYseXJdtYpQ2qFSrEjeU6NrhL7GI7HX0u7nkEnol0jTaExJUt_d8559d_kuQxgm8QLMkhLjNG8jvJCBWYpoQgfDcZQZhlKSoZ20sehLCEEOaY0PvJHiog7X_ZKPl1oULXxACcBgJUm-ha9VU0bm18F8Cr6nz-Op2tlDTaSFAdlQeHExuV18o7m_7-eXAtuTRWgZPGXQ0G0W_AOASxAZXzXjUiKnBl4jdQNcYaKRpwvDa1slJtY6feRSWjWSswadvOmrgBxoKpiEbZfrNr5XhyNBs8zufgQsXeKJrwMLmnRRPUo-HdTz6dHH-sTtOzD-8m1fgslXkBY5pThBmChMK8lnChM60xZLXOGa5rUmelopqiUlKNSJ4vsMhKphdMF0V_VaQLvJ-83PmuvPveqRB5a4JUTSOscl3gvRgyUpQ9-PwfcOk6b_vdeJZhBktK4K2b9C4ErzRfedMKv-EI8m2dfFdnDz4d3LpFq-pbbOivB14MgAj9XbUXVprwF0dJxuh2_2c7znWr_4c92THLEJ2_oTCEtGDFNivdzU2I6sfNXPhLTiimBT_9_IWz4u37Gc7nfIr_AJmrynM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223908760</pqid></control><display><type>article</type><title>Results of a Cytomegalovirus (CMV)-Specific CD8+/Interferon-γ+ Cytokine Flow Cytometry Assay Correlate with Clinical Evidence of Protective Immunity in Patients with AIDS with CMV Retinitis</title><source>Jstor Complete Legacy</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Jacobson, Mark A. ; Maecker, Holden T. ; Orr, Patricia L. ; D'Amico, Ron ; Van Natta, Mark ; Li, Xiao-Dong ; Pollard, Richard B. ; Bredt, Barry M.</creator><creatorcontrib>Jacobson, Mark A. ; Maecker, Holden T. ; Orr, Patricia L. ; D'Amico, Ron ; Van Natta, Mark ; Li, Xiao-Dong ; Pollard, Richard B. ; Bredt, Barry M. ; Adult Aids clinical Trials Group ; Studies of Ocular Complications of AIDS Research Group ; Adult AIDS Clinical Trials Group and the Studies of Ocular Complications of AIDS Research Group ; the Adult AIDS Clinical Trials Group and the Studies of Ocular Complications of AIDS Research Group</creatorcontrib><description>To evaluate the potential clinical utility of a cytomegalovirus (CMV)-specific CD8+/interferon (IFN)-γ+ cytokine flow cytometry (CFC) assay for patients with CMV retinitis (CMVR), stored peripheral blood mononuclear cell specimens were obtained from patients with active CMVR (i.e., having clinical evidence of absent CMVprotective immunity), as well as from highly active antiretroviral therapy-treated patients with CMVR who were able to discontinue anti-CMV therapy without subsequent progression of retinitis (i.e., having clinical evidence of restored CMV-protective immunity). Positive CD8+/IFN-γ+ T lymphocyte responses to CMV phosphoprotein 65 or immediate early peptide-pool stimulation were present in specimens from only 3 of 10 patients with active CMVR but were present in at least 1 specimen from all 20 patients with immunorestored CMVR, with a mean of 2.4 specimens/patient tested, spanning up to 6 months of observation (P = .0001). Among the patients with immunorestored CMVR, positive responses were present in all longitudinal specimens from 15 of the 20 patients. These data suggest that further testing of the CMV-specific CD8+/IFN-γ+ CFC assay, for clinical utility in predicting incident and progressive CMVR disease, is warranted.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/382964</identifier><identifier>PMID: 15073672</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; AIDS ; AIDS-Related Opportunistic Infections - drug therapy ; AIDS-Related Opportunistic Infections - immunology ; AIDS-Related Opportunistic Infections - virology ; Antigens ; Antiretroviral Therapy, Highly Active - standards ; Biological and medical sciences ; Blood ; CD8-Positive T-Lymphocytes - cytology ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - virology ; Cell Division - immunology ; Chlorofluorocarbons ; Cytomegalovirus ; Cytomegalovirus - immunology ; Cytomegalovirus Retinitis - drug therapy ; Cytomegalovirus Retinitis - immunology ; Cytomegalovirus Retinitis - virology ; Female ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; Highly active antiretroviral therapy ; HIV - immunology ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV Infections - virology ; Human viral diseases ; Humans ; Immediate-Early Proteins - immunology ; Immunity ; Infectious diseases ; Interferon-gamma - immunology ; Longitudinal Studies ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Phosphoproteins - immunology ; Retinitis ; Specimens ; T lymphocytes ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Matrix Proteins - immunology ; Virology ; Viruses</subject><ispartof>The Journal of infectious diseases, 2004-04, Vol.189 (8), p.1362-1373</ispartof><rights>Copyright 2003 Infectious Diseases Society of America</rights><rights>2004 by the Infectious Diseases Society of America 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Apr 15 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-47139106704dc0bf2ff309df493dd6d28e7f718c7f1644b3a289fb9f552961f53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30075952$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30075952$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15762975$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15073672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacobson, Mark A.</creatorcontrib><creatorcontrib>Maecker, Holden T.</creatorcontrib><creatorcontrib>Orr, Patricia L.</creatorcontrib><creatorcontrib>D'Amico, Ron</creatorcontrib><creatorcontrib>Van Natta, Mark</creatorcontrib><creatorcontrib>Li, Xiao-Dong</creatorcontrib><creatorcontrib>Pollard, Richard B.</creatorcontrib><creatorcontrib>Bredt, Barry M.</creatorcontrib><creatorcontrib>Adult Aids clinical Trials Group</creatorcontrib><creatorcontrib>Studies of Ocular Complications of AIDS Research Group</creatorcontrib><creatorcontrib>Adult AIDS Clinical Trials Group and the Studies of Ocular Complications of AIDS Research Group</creatorcontrib><creatorcontrib>the Adult AIDS Clinical Trials Group and the Studies of Ocular Complications of AIDS Research Group</creatorcontrib><title>Results of a Cytomegalovirus (CMV)-Specific CD8+/Interferon-γ+ Cytokine Flow Cytometry Assay Correlate with Clinical Evidence of Protective Immunity in Patients with AIDS with CMV Retinitis</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>To evaluate the potential clinical utility of a cytomegalovirus (CMV)-specific CD8+/interferon (IFN)-γ+ cytokine flow cytometry (CFC) assay for patients with CMV retinitis (CMVR), stored peripheral blood mononuclear cell specimens were obtained from patients with active CMVR (i.e., having clinical evidence of absent CMVprotective immunity), as well as from highly active antiretroviral therapy-treated patients with CMVR who were able to discontinue anti-CMV therapy without subsequent progression of retinitis (i.e., having clinical evidence of restored CMV-protective immunity). Positive CD8+/IFN-γ+ T lymphocyte responses to CMV phosphoprotein 65 or immediate early peptide-pool stimulation were present in specimens from only 3 of 10 patients with active CMVR but were present in at least 1 specimen from all 20 patients with immunorestored CMVR, with a mean of 2.4 specimens/patient tested, spanning up to 6 months of observation (P = .0001). Among the patients with immunorestored CMVR, positive responses were present in all longitudinal specimens from 15 of the 20 patients. These data suggest that further testing of the CMV-specific CD8+/IFN-γ+ CFC assay, for clinical utility in predicting incident and progressive CMVR disease, is warranted.</description><subject>Adult</subject><subject>AIDS</subject><subject>AIDS-Related Opportunistic Infections - drug therapy</subject><subject>AIDS-Related Opportunistic Infections - immunology</subject><subject>AIDS-Related Opportunistic Infections - virology</subject><subject>Antigens</subject><subject>Antiretroviral Therapy, Highly Active - standards</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>CD8-Positive T-Lymphocytes - cytology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - virology</subject><subject>Cell Division - immunology</subject><subject>Chlorofluorocarbons</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - immunology</subject><subject>Cytomegalovirus Retinitis - drug therapy</subject><subject>Cytomegalovirus Retinitis - immunology</subject><subject>Cytomegalovirus Retinitis - virology</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV - immunology</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immediate-Early Proteins - immunology</subject><subject>Immunity</subject><subject>Infectious diseases</subject><subject>Interferon-gamma - immunology</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Phosphoproteins - immunology</subject><subject>Retinitis</subject><subject>Specimens</subject><subject>T lymphocytes</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Matrix Proteins - immunology</subject><subject>Virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kdFu0zAYhSMEYmXAG4AMEgg0hdlxYseXJdtYpQ2qFSrEjeU6NrhL7GI7HX0u7nkEnol0jTaExJUt_d8559d_kuQxgm8QLMkhLjNG8jvJCBWYpoQgfDcZQZhlKSoZ20sehLCEEOaY0PvJHiog7X_ZKPl1oULXxACcBgJUm-ha9VU0bm18F8Cr6nz-Op2tlDTaSFAdlQeHExuV18o7m_7-eXAtuTRWgZPGXQ0G0W_AOASxAZXzXjUiKnBl4jdQNcYaKRpwvDa1slJtY6feRSWjWSswadvOmrgBxoKpiEbZfrNr5XhyNBs8zufgQsXeKJrwMLmnRRPUo-HdTz6dHH-sTtOzD-8m1fgslXkBY5pThBmChMK8lnChM60xZLXOGa5rUmelopqiUlKNSJ4vsMhKphdMF0V_VaQLvJ-83PmuvPveqRB5a4JUTSOscl3gvRgyUpQ9-PwfcOk6b_vdeJZhBktK4K2b9C4ErzRfedMKv-EI8m2dfFdnDz4d3LpFq-pbbOivB14MgAj9XbUXVprwF0dJxuh2_2c7znWr_4c92THLEJ2_oTCEtGDFNivdzU2I6sfNXPhLTiimBT_9_IWz4u37Gc7nfIr_AJmrynM</recordid><startdate>20040415</startdate><enddate>20040415</enddate><creator>Jacobson, Mark A.</creator><creator>Maecker, Holden T.</creator><creator>Orr, Patricia L.</creator><creator>D'Amico, Ron</creator><creator>Van Natta, Mark</creator><creator>Li, Xiao-Dong</creator><creator>Pollard, Richard B.</creator><creator>Bredt, Barry M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20040415</creationdate><title>Results of a Cytomegalovirus (CMV)-Specific CD8+/Interferon-γ+ Cytokine Flow Cytometry Assay Correlate with Clinical Evidence of Protective Immunity in Patients with AIDS with CMV Retinitis</title><author>Jacobson, Mark A. ; Maecker, Holden T. ; Orr, Patricia L. ; D'Amico, Ron ; Van Natta, Mark ; Li, Xiao-Dong ; Pollard, Richard B. ; Bredt, Barry M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-47139106704dc0bf2ff309df493dd6d28e7f718c7f1644b3a289fb9f552961f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>AIDS</topic><topic>AIDS-Related Opportunistic Infections - drug therapy</topic><topic>AIDS-Related Opportunistic Infections - immunology</topic><topic>AIDS-Related Opportunistic Infections - virology</topic><topic>Antigens</topic><topic>Antiretroviral Therapy, Highly Active - standards</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>CD8-Positive T-Lymphocytes - cytology</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - virology</topic><topic>Cell Division - immunology</topic><topic>Chlorofluorocarbons</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus - immunology</topic><topic>Cytomegalovirus Retinitis - drug therapy</topic><topic>Cytomegalovirus Retinitis - immunology</topic><topic>Cytomegalovirus Retinitis - virology</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Highly active antiretroviral therapy</topic><topic>HIV - immunology</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - virology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immediate-Early Proteins - immunology</topic><topic>Immunity</topic><topic>Infectious diseases</topic><topic>Interferon-gamma - immunology</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Phosphoproteins - immunology</topic><topic>Retinitis</topic><topic>Specimens</topic><topic>T lymphocytes</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Matrix Proteins - immunology</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jacobson, Mark A.</creatorcontrib><creatorcontrib>Maecker, Holden T.</creatorcontrib><creatorcontrib>Orr, Patricia L.</creatorcontrib><creatorcontrib>D'Amico, Ron</creatorcontrib><creatorcontrib>Van Natta, Mark</creatorcontrib><creatorcontrib>Li, Xiao-Dong</creatorcontrib><creatorcontrib>Pollard, Richard B.</creatorcontrib><creatorcontrib>Bredt, Barry M.</creatorcontrib><creatorcontrib>Adult Aids clinical Trials Group</creatorcontrib><creatorcontrib>Studies of Ocular Complications of AIDS Research Group</creatorcontrib><creatorcontrib>Adult AIDS Clinical Trials Group and the Studies of Ocular Complications of AIDS Research Group</creatorcontrib><creatorcontrib>the Adult AIDS Clinical Trials Group and the Studies of Ocular Complications of AIDS Research Group</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jacobson, Mark A.</au><au>Maecker, Holden T.</au><au>Orr, Patricia L.</au><au>D'Amico, Ron</au><au>Van Natta, Mark</au><au>Li, Xiao-Dong</au><au>Pollard, Richard B.</au><au>Bredt, Barry M.</au><aucorp>Adult Aids clinical Trials Group</aucorp><aucorp>Studies of Ocular Complications of AIDS Research Group</aucorp><aucorp>Adult AIDS Clinical Trials Group and the Studies of Ocular Complications of AIDS Research Group</aucorp><aucorp>the Adult AIDS Clinical Trials Group and the Studies of Ocular Complications of AIDS Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Results of a Cytomegalovirus (CMV)-Specific CD8+/Interferon-γ+ Cytokine Flow Cytometry Assay Correlate with Clinical Evidence of Protective Immunity in Patients with AIDS with CMV Retinitis</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2004-04-15</date><risdate>2004</risdate><volume>189</volume><issue>8</issue><spage>1362</spage><epage>1373</epage><pages>1362-1373</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To evaluate the potential clinical utility of a cytomegalovirus (CMV)-specific CD8+/interferon (IFN)-γ+ cytokine flow cytometry (CFC) assay for patients with CMV retinitis (CMVR), stored peripheral blood mononuclear cell specimens were obtained from patients with active CMVR (i.e., having clinical evidence of absent CMVprotective immunity), as well as from highly active antiretroviral therapy-treated patients with CMVR who were able to discontinue anti-CMV therapy without subsequent progression of retinitis (i.e., having clinical evidence of restored CMV-protective immunity). Positive CD8+/IFN-γ+ T lymphocyte responses to CMV phosphoprotein 65 or immediate early peptide-pool stimulation were present in specimens from only 3 of 10 patients with active CMVR but were present in at least 1 specimen from all 20 patients with immunorestored CMVR, with a mean of 2.4 specimens/patient tested, spanning up to 6 months of observation (P = .0001). Among the patients with immunorestored CMVR, positive responses were present in all longitudinal specimens from 15 of the 20 patients. These data suggest that further testing of the CMV-specific CD8+/IFN-γ+ CFC assay, for clinical utility in predicting incident and progressive CMVR disease, is warranted.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>15073672</pmid><doi>10.1086/382964</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2004-04, Vol.189 (8), p.1362-1373 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71809658 |
| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult AIDS AIDS-Related Opportunistic Infections - drug therapy AIDS-Related Opportunistic Infections - immunology AIDS-Related Opportunistic Infections - virology Antigens Antiretroviral Therapy, Highly Active - standards Biological and medical sciences Blood CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - virology Cell Division - immunology Chlorofluorocarbons Cytomegalovirus Cytomegalovirus - immunology Cytomegalovirus Retinitis - drug therapy Cytomegalovirus Retinitis - immunology Cytomegalovirus Retinitis - virology Female Flow Cytometry Fundamental and applied biological sciences. Psychology Highly active antiretroviral therapy HIV - immunology HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology Human viral diseases Humans Immediate-Early Proteins - immunology Immunity Infectious diseases Interferon-gamma - immunology Longitudinal Studies Male Medical sciences Microbiology Middle Aged Miscellaneous Phosphoproteins - immunology Retinitis Specimens T lymphocytes Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Matrix Proteins - immunology Virology Viruses |
| title | Results of a Cytomegalovirus (CMV)-Specific CD8+/Interferon-γ+ Cytokine Flow Cytometry Assay Correlate with Clinical Evidence of Protective Immunity in Patients with AIDS with CMV Retinitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T04%3A10%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Results%20of%20a%20Cytomegalovirus%20(CMV)-Specific%20CD8+/Interferon-%CE%B3+%20Cytokine%20Flow%20Cytometry%20Assay%20Correlate%20with%20Clinical%20Evidence%20of%20Protective%20Immunity%20in%20Patients%20with%20AIDS%20with%20CMV%20Retinitis&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=Jacobson,%20Mark%20A.&rft.aucorp=Adult%20Aids%20clinical%20Trials%20Group&rft.date=2004-04-15&rft.volume=189&rft.issue=8&rft.spage=1362&rft.epage=1373&rft.pages=1362-1373&rft.issn=0022-1899&rft.eissn=1537-6613&rft.coden=JIDIAQ&rft_id=info:doi/10.1086/382964&rft_dat=%3Cjstor_proqu%3E30075952%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223908760&rft_id=info:pmid/15073672&rft_jstor_id=30075952&rft_oup_id=10.1086/382964&rfr_iscdi=true |