Amending of fluorescence sensor signal localization in human skin by matching of the refractive index
Fluorescence diagnostic techniques are notable amongst many other optical methods because they offer high sensitivity and noninvasive measurement of tissue properties. However, a combination of multiple scattering and physical heterogeneity of biological tissues hampers interpretation of the fluores...
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| Veröffentlicht in: | Journal of Biomedical Optics 2004-03, Vol.9 (2), p.339-346 |
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| creator | Churmakov, Dmitry Y Meglinski, Igor V Greenhalgh, Douglas A |
| description | Fluorescence diagnostic techniques are notable amongst many other optical methods because they offer high sensitivity and noninvasive measurement of tissue properties. However, a combination of multiple scattering and physical heterogeneity of biological tissues hampers interpretation of the fluorescence measurements. Analyses of the spatial distribution of endogenous and exogenous fluorophores excitation within tissues and their contribution to the detected signal localization are essential for many applications. We have developed a novel Monte Carlo technique that gives a graphical perception of how the excitation and fluorescence detected signal are localized in tissues. Our model takes into account the spatial distribution of fluorophores, the variation of concentrations and quantum yield. We demonstrate that matching the refractive indices of the ambient medium and topical skin layer improves spatial localization of the detected fluorescence signal within the tissues. © |
| doi_str_mv | 10.1117/1.1645796 |
| format | Article |
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However, a combination of multiple scattering and physical heterogeneity of biological tissues hampers interpretation of the fluorescence measurements. Analyses of the spatial distribution of endogenous and exogenous fluorophores excitation within tissues and their contribution to the detected signal localization are essential for many applications. We have developed a novel Monte Carlo technique that gives a graphical perception of how the excitation and fluorescence detected signal are localized in tissues. Our model takes into account the spatial distribution of fluorophores, the variation of concentrations and quantum yield. 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We demonstrate that matching the refractive indices of the ambient medium and topical skin layer improves spatial localization of the detected fluorescence signal within the tissues. ©</description><subject>Computer Simulation</subject><subject>Fluorescence</subject><subject>fluorescence localization</subject><subject>Humans</subject><subject>Models, Theoretical</subject><subject>Monte Carlo Method</subject><subject>Monte Carlo simulation</subject><subject>refractive index matching</subject><subject>Refractometry</subject><subject>sampling volume</subject><subject>Skin Physiological Phenomena</subject><subject>skin tissues</subject><subject>Spectrometry, Fluorescence - methods</subject><subject>tattoo</subject><issn>1083-3668</issn><issn>1560-2281</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP3TAQha0KVB7ton8AeYXEIuCxY8de0iserZAuC7qOHGfMdUmc2zhBhV-P6Y3aZUeamSPNpyPNIeQLsHMAqC7gHFQpK6M-kEOQihWca9jLmmlRCKX0ATlK6SdjTCujPpIDkExJw9ghwcseYxviIx089d08jJgcRoc0YUzDSFN4jLaj3eBsF17tFIZIQ6SbubeRpqcsmxfa28ltFpNpg3REP1o3hWfMbIu_P5F9b7uEn5d9TH5cXz2sbou79c231eVd4YRhU-GxbH1pQUvZGOcdmEYzy72EkjvRQgkgeYNGWatZZRVvhZeysiAMb40HcUxOd77bcfg1Y5rqPuR3us5GHOZUV6BZNv8_yI1WHEBn8GwHunFIKf9Vb8fQ2_GlBla_h19DvYSf2ZPFdG56bP-RS9oZ4DsgbQP-PX__ur6_XrP3Mn8mzy3EToN4A-m-jQM</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Churmakov, Dmitry Y</creator><creator>Meglinski, Igor V</creator><creator>Greenhalgh, Douglas A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Amending of fluorescence sensor signal localization in human skin by matching of the refractive index</title><author>Churmakov, Dmitry Y ; Meglinski, Igor V ; Greenhalgh, Douglas A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-fe4df4a1855b9cfc19b80a2f5142c3d141152be96aa807a62d3f557a1392d9f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Computer Simulation</topic><topic>Fluorescence</topic><topic>fluorescence localization</topic><topic>Humans</topic><topic>Models, Theoretical</topic><topic>Monte Carlo Method</topic><topic>Monte Carlo simulation</topic><topic>refractive index matching</topic><topic>Refractometry</topic><topic>sampling volume</topic><topic>Skin Physiological Phenomena</topic><topic>skin tissues</topic><topic>Spectrometry, Fluorescence - methods</topic><topic>tattoo</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Churmakov, Dmitry Y</creatorcontrib><creatorcontrib>Meglinski, Igor V</creatorcontrib><creatorcontrib>Greenhalgh, Douglas A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Biomedical Optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Churmakov, Dmitry Y</au><au>Meglinski, Igor V</au><au>Greenhalgh, Douglas A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amending of fluorescence sensor signal localization in human skin by matching of the refractive index</atitle><jtitle>Journal of Biomedical Optics</jtitle><addtitle>J Biomed Opt</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>9</volume><issue>2</issue><spage>339</spage><epage>346</epage><pages>339-346</pages><issn>1083-3668</issn><eissn>1560-2281</eissn><coden>JBOPFO</coden><abstract>Fluorescence diagnostic techniques are notable amongst many other optical methods because they offer high sensitivity and noninvasive measurement of tissue properties. 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| subjects | Computer Simulation Fluorescence fluorescence localization Humans Models, Theoretical Monte Carlo Method Monte Carlo simulation refractive index matching Refractometry sampling volume Skin Physiological Phenomena skin tissues Spectrometry, Fluorescence - methods tattoo |
| title | Amending of fluorescence sensor signal localization in human skin by matching of the refractive index |
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