Tuberculosis‐like lesions arising from the use of Freund's complete adjuvant in an owl monkey (Aotus sp.)

:  An apparently normal, non‐tuberculin‐reacting, splenectomized owl monkey presented tuberculosis‐like lesions of the lung at necropsy. Histological and bacteriological examination failed to demonstrate the presence of acid‐fast organisms. Retrospective inquiry showed the animal had been inoculated...

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Veröffentlicht in:Journal of Medical Primatology 2004-04, Vol.33 (2), p.109-112
Hauptverfasser: Málaga, Carlos A., Weller, Richard E., Roger Broderson, J., Gozalo, Alfonso S.
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Sprache:eng
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Zusammenfassung::  An apparently normal, non‐tuberculin‐reacting, splenectomized owl monkey presented tuberculosis‐like lesions of the lung at necropsy. Histological and bacteriological examination failed to demonstrate the presence of acid‐fast organisms. Retrospective inquiry showed the animal had been inoculated using complete Freund's Adjuvant during a malaria vaccine trial. Lesions observed were compatible with lipid embolism of the adjuvant in the lungs.
ISSN:0047-2565
1600-0684
DOI:10.1111/j.1600-0684.2004.00060.x