Total synthesis of (-)-bafilomycin A(1)

A highly stereoselective total synthesis of (-)-bafilomycin A(1), the naturally occurring enantiomer of this potent vacuolar ATPase inhibitor, is described. The synthesis features the highly stereoselective aldol reaction of methyl ketone 8b and aldehyde 60c and a Suzuki cross-coupling reaction of t...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2002-06, Vol.124 (24), p.6981-6990
Hauptverfasser:	Scheidt, Karl A, Bannister, Thomas D, Tasaka, Akihiro, Wendt, Michael D, Savall, Brad M, Fegley, Glenn J, Roush, William R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Antifungal Agents - chemical synthesis Enzyme Inhibitors - chemical synthesis Macrolides Stereoisomerism Vacuolar Proton-Translocating ATPases - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!