Differential regulation of apoptotic genes by Rb in human versus mouse cells

The retinoblastoma protein (Rb) controls cellular proliferation and suppresses tumor formation through its effects upon E2F transcriptional regulation of the cell cycle. Unexpectedly, however, in proliferating human cells, Rb was present at the promoters of eight of eight E2F-regulated apoptotic gen...

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Veröffentlicht in:	Oncogene 2004-04, Vol.23 (15), p.2587-2599
Hauptverfasser:	Young, Arthur P, Longmore, Gregory D
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Animals Apoptosis Binding Sites Biological and medical sciences Blotting, Northern Blotting, Western Cancer Cell Biology Cell Cycle Cell Cycle Proteins Cell death Cell Differentiation Cell Division Cell Line Cell Line, Tumor Cell physiology Cell proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells, Cultured Chromatin - metabolism DNA-Binding Proteins E2F protein E2F Transcription Factors Fibroblasts Fibroblasts - metabolism Flow Cytometry Fundamental and applied biological sciences. Psychology Gene regulation Genes Human Genetics Humans Internal Medicine Keratinocytes - metabolism Kinetics Medicine Medicine & Public Health Mice Mice, Inbred C57BL Molecular and cellular biology Oncology original-paper Precipitin Tests Promoter Regions, Genetic Promoters Protein Binding Protein folding Retina Retinoblastoma Retinoblastoma protein Retinoblastoma Protein - metabolism Retroviridae - genetics RNA - metabolism Time Factors Transcription Transcription Factors - metabolism Transcription, Genetic Tumors
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