Reliability of diagnosis of melanoma in situ
Early and correct diagnosis of malignant melanoma is of utmost importance to ensure adequate treatment and the best outcome. Prompted by the death of a patient with an apparent metastasising melanoma in situ, we reassessed 104 people with this malignant disorder, whose diagnosis had been histopathol...
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| Veröffentlicht in: | The Lancet (British edition) 2002-06, Vol.359 (9321), p.1921-1922 |
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| container_issue | 9321 |
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| container_title | The Lancet (British edition) |
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| creator | Megahed, Mosaad Schön, Margarete Selimovic, Dennis Schön, Michael P |
| description | Early and correct diagnosis of malignant melanoma is of utmost importance to ensure adequate treatment and the best outcome. Prompted by the death of a patient with an apparent metastasising melanoma in situ, we reassessed 104 people with this malignant disorder, whose diagnosis had been histopathologically verified. We did immuno-histochemical analysis of cells with the melanocytic marker melan-A/MART-1, and results of this analysis showed that 30 (29%) of 104 patients had invasive melanomas. One patient died of distant metastases, and the tumour recurred in another. Our finding could be relevant for diagnosis and treatment of melanoma in situ. |
| doi_str_mv | 10.1016/S0140-6736(02)08741-X |
| format | Article |
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Prompted by the death of a patient with an apparent metastasising melanoma in situ, we reassessed 104 people with this malignant disorder, whose diagnosis had been histopathologically verified. We did immuno-histochemical analysis of cells with the melanocytic marker melan-A/MART-1, and results of this analysis showed that 30 (29%) of 104 patients had invasive melanomas. One patient died of distant metastases, and the tumour recurred in another. Our finding could be relevant for diagnosis and treatment of melanoma in situ.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(02)08741-X</identifier><identifier>PMID: 12057558</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Antigens, Neoplasm ; Biological and medical sciences ; Dermatology ; Diagnosis ; Fatal Outcome ; Hematoxylin ; Histochemical analysis ; Humans ; Lymphatic Metastasis ; Male ; MART-1 Antigen ; Medical diagnosis ; Medical research ; Medical sciences ; Melanoma ; Melanoma - diagnosis ; Melanoma - pathology ; Metastases ; Metastasis ; Middle Aged ; Neoplasm Proteins ; Patients ; Phosphatase ; Reproducibility of Results ; Skin cancer ; Skin Neoplasms - diagnosis ; Skin Neoplasms - pathology ; Tumors ; Tumors of the skin and soft tissue. 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Prompted by the death of a patient with an apparent metastasising melanoma in situ, we reassessed 104 people with this malignant disorder, whose diagnosis had been histopathologically verified. We did immuno-histochemical analysis of cells with the melanocytic marker melan-A/MART-1, and results of this analysis showed that 30 (29%) of 104 patients had invasive melanomas. One patient died of distant metastases, and the tumour recurred in another. Our finding could be relevant for diagnosis and treatment of melanoma in situ.</description><subject>Antigens, Neoplasm</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Diagnosis</subject><subject>Fatal Outcome</subject><subject>Hematoxylin</subject><subject>Histochemical analysis</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>MART-1 Antigen</subject><subject>Medical diagnosis</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Melanoma</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - pathology</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins</subject><subject>Patients</subject><subject>Phosphatase</subject><subject>Reproducibility of Results</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - pathology</subject><subject>Tumors</subject><subject>Tumors of the skin and soft tissue. 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| subjects | Antigens, Neoplasm Biological and medical sciences Dermatology Diagnosis Fatal Outcome Hematoxylin Histochemical analysis Humans Lymphatic Metastasis Male MART-1 Antigen Medical diagnosis Medical research Medical sciences Melanoma Melanoma - diagnosis Melanoma - pathology Metastases Metastasis Middle Aged Neoplasm Proteins Patients Phosphatase Reproducibility of Results Skin cancer Skin Neoplasms - diagnosis Skin Neoplasms - pathology Tumors Tumors of the skin and soft tissue. Premalignant lesions |
| title | Reliability of diagnosis of melanoma in situ |
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