Previous mood state predicts response and switch rates in patients with bipolar depression
Objective: The treatment of bipolar depression is a significant clinical problem that remains understudied. The role for antidepressant (AD) agents vs. mood stabilizers has been particularly problematic to ascertain. Method: Detailed life charting data from 42 patients with 67 depressive episodes we...
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| Veröffentlicht in: | Acta psychiatrica Scandinavica 2002-06, Vol.105 (6), p.414-418 |
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| container_title | Acta psychiatrica Scandinavica |
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| creator | MacQueen, Glenda M. Trevor Young, L. Marriott, Michael Robb, Janine Begin, Helen Joffe, Russell T. |
| description | Objective: The treatment of bipolar depression is a significant clinical problem that remains understudied. The role for antidepressant (AD) agents vs. mood stabilizers has been particularly problematic to ascertain.
Method: Detailed life charting data from 42 patients with 67 depressive episodes were reviewed. Response rates and rates of switch into mania were compared based on the preceding mood state and on whether an AD or mood stabilizing (MS) agent was added following onset of depression.
Results: Patients who became depressed following a period of euthymia were more likely to respond to treatment (62.5%) than patients who became depressed following a period of mania or hypomania (27.9%). The ratio of response to switch for previously euthymic patients was particularly favorable.
Conclusion: Mood state prior to onset of depression in bipolar disorder appears to be an important clinical variable that may guide both choice of treatment administered and expectation of outcome to treatment. |
| doi_str_mv | 10.1034/j.1600-0447.2002.01116.x |
| format | Article |
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Method: Detailed life charting data from 42 patients with 67 depressive episodes were reviewed. Response rates and rates of switch into mania were compared based on the preceding mood state and on whether an AD or mood stabilizing (MS) agent was added following onset of depression.
Results: Patients who became depressed following a period of euthymia were more likely to respond to treatment (62.5%) than patients who became depressed following a period of mania or hypomania (27.9%). The ratio of response to switch for previously euthymic patients was particularly favorable.
Conclusion: Mood state prior to onset of depression in bipolar disorder appears to be an important clinical variable that may guide both choice of treatment administered and expectation of outcome to treatment.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1034/j.1600-0447.2002.01116.x</identifier><identifier>PMID: 12059844</identifier><identifier>CODEN: APYSA9</identifier><language>eng</language><publisher>Oxford UK: Munksgaard International Publishers</publisher><subject>Adolescent ; Adult ; Aged ; antidepressants ; Biological and medical sciences ; bipolar depression ; Bipolar Disorder - drug therapy ; Bipolar Disorder - epidemiology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; mood disorders ; Mood Disorders - diagnosis ; Mood Disorders - epidemiology ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Severity of Illness Index ; Time Factors</subject><ispartof>Acta psychiatrica Scandinavica, 2002-06, Vol.105 (6), p.414-418</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4346-22c3c3d9ce506512730d875063db81ada9163e2a33eca01325333ca306d28a153</citedby><cites>FETCH-LOGICAL-c4346-22c3c3d9ce506512730d875063db81ada9163e2a33eca01325333ca306d28a153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1600-0447.2002.01116.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1600-0447.2002.01116.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13731162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12059844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MacQueen, Glenda M.</creatorcontrib><creatorcontrib>Trevor Young, L.</creatorcontrib><creatorcontrib>Marriott, Michael</creatorcontrib><creatorcontrib>Robb, Janine</creatorcontrib><creatorcontrib>Begin, Helen</creatorcontrib><creatorcontrib>Joffe, Russell T.</creatorcontrib><title>Previous mood state predicts response and switch rates in patients with bipolar depression</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Objective: The treatment of bipolar depression is a significant clinical problem that remains understudied. The role for antidepressant (AD) agents vs. mood stabilizers has been particularly problematic to ascertain.
Method: Detailed life charting data from 42 patients with 67 depressive episodes were reviewed. Response rates and rates of switch into mania were compared based on the preceding mood state and on whether an AD or mood stabilizing (MS) agent was added following onset of depression.
Results: Patients who became depressed following a period of euthymia were more likely to respond to treatment (62.5%) than patients who became depressed following a period of mania or hypomania (27.9%). The ratio of response to switch for previously euthymic patients was particularly favorable.
Conclusion: Mood state prior to onset of depression in bipolar disorder appears to be an important clinical variable that may guide both choice of treatment administered and expectation of outcome to treatment.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>antidepressants</subject><subject>Biological and medical sciences</subject><subject>bipolar depression</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Bipolar Disorder - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mood disorders</subject><subject>Mood Disorders - diagnosis</subject><subject>Mood Disorders - epidemiology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFv1DAQhS0EokvhLyBf4JYw9sROckGqVrQgVVAJEGgvltf2ql6ySfBk6fbf47Cr9srJM57vvbEfY1xAKQCrd9tSaIACqqouJYAsQQihy8MTtngYPGULABCFbuHnGXtBtM2tEtA8Z2dCgmqbqlqw1U0Kf-KwJ74bBs9pslPgYwo-uol4CjQOPQVu-zy7i5O75SkTxGPPRzvF0Gcq39_ydRyHzibuQ1YTxaF_yZ5tbEfh1ek8Z98vP3xbfiyuv1x9Wl5cF67CShdSOnToWxcUaCVkjeCbOtfo142w3rZCY5AWMTgLAqVCRGcRtJeNFQrP2duj75iG3_tAk9lFcqHrbB_yx0wtGlBQ6ww2R9ClgSiFjRlT3Nl0bwSYOVezNXN8Zo7PzLmaf7maQ5a-Pu3Yr3fBPwpPQWbgzQmw5Gy3SbZ3kR45rDE7ycy9P3J3sQv3__0Ac7G8-TqX2aA4GkSawuHBwKZfRtdYK_Pj85WpVHu5UrlZ4V_sPKJ7</recordid><startdate>200206</startdate><enddate>200206</enddate><creator>MacQueen, Glenda M.</creator><creator>Trevor Young, L.</creator><creator>Marriott, Michael</creator><creator>Robb, Janine</creator><creator>Begin, Helen</creator><creator>Joffe, Russell T.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200206</creationdate><title>Previous mood state predicts response and switch rates in patients with bipolar depression</title><author>MacQueen, Glenda M. ; Trevor Young, L. ; Marriott, Michael ; Robb, Janine ; Begin, Helen ; Joffe, Russell T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4346-22c3c3d9ce506512730d875063db81ada9163e2a33eca01325333ca306d28a153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>antidepressants</topic><topic>Biological and medical sciences</topic><topic>bipolar depression</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Bipolar Disorder - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>mood disorders</topic><topic>Mood Disorders - diagnosis</topic><topic>Mood Disorders - epidemiology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Severity of Illness Index</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MacQueen, Glenda M.</creatorcontrib><creatorcontrib>Trevor Young, L.</creatorcontrib><creatorcontrib>Marriott, Michael</creatorcontrib><creatorcontrib>Robb, Janine</creatorcontrib><creatorcontrib>Begin, Helen</creatorcontrib><creatorcontrib>Joffe, Russell T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MacQueen, Glenda M.</au><au>Trevor Young, L.</au><au>Marriott, Michael</au><au>Robb, Janine</au><au>Begin, Helen</au><au>Joffe, Russell T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Previous mood state predicts response and switch rates in patients with bipolar depression</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2002-06</date><risdate>2002</risdate><volume>105</volume><issue>6</issue><spage>414</spage><epage>418</epage><pages>414-418</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><coden>APYSA9</coden><abstract>Objective: The treatment of bipolar depression is a significant clinical problem that remains understudied. The role for antidepressant (AD) agents vs. mood stabilizers has been particularly problematic to ascertain.
Method: Detailed life charting data from 42 patients with 67 depressive episodes were reviewed. Response rates and rates of switch into mania were compared based on the preceding mood state and on whether an AD or mood stabilizing (MS) agent was added following onset of depression.
Results: Patients who became depressed following a period of euthymia were more likely to respond to treatment (62.5%) than patients who became depressed following a period of mania or hypomania (27.9%). The ratio of response to switch for previously euthymic patients was particularly favorable.
Conclusion: Mood state prior to onset of depression in bipolar disorder appears to be an important clinical variable that may guide both choice of treatment administered and expectation of outcome to treatment.</abstract><cop>Oxford UK</cop><pub>Munksgaard International Publishers</pub><pmid>12059844</pmid><doi>10.1034/j.1600-0447.2002.01116.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged antidepressants Biological and medical sciences bipolar depression Bipolar Disorder - drug therapy Bipolar Disorder - epidemiology Female Humans Male Medical sciences Middle Aged mood disorders Mood Disorders - diagnosis Mood Disorders - epidemiology Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Severity of Illness Index Time Factors |
| title | Previous mood state predicts response and switch rates in patients with bipolar depression |
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