Selective termination for fetal anomaly/ genetic disorder in twin pregnancy at 32+ menstrual weeks: Report of four cases
To conduct a pilot study of 4 cases of selective termination of a single abnormal fetus in a dichorionic, diamniotic twin pregnancy advanced to 32 or more menstrual weeks of gestation. This is a case series of 4 patients in highly unusual circumstances and treatment. Four healthy patients with desir...
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| Veröffentlicht in: | Fetal diagnosis and therapy 2004-05, Vol.19 (3), p.292-295 |
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| container_title | Fetal diagnosis and therapy |
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| creator | HERN, Warren M |
| description | To conduct a pilot study of 4 cases of selective termination of a single abnormal fetus in a dichorionic, diamniotic twin pregnancy advanced to 32 or more menstrual weeks of gestation.
This is a case series of 4 patients in highly unusual circumstances and treatment. Four healthy patients with desired pregnancies complicated by the presence of an abnormal genetic or developmental diagnosis in 1 twin were treated by selective termination of the abnormal twin using intracardiac injection of potassium chloride.
In all 4 patients, cardiac arrest in the abnormal twin was effected without disturbance of the healthy twin or the mother. Postoperative maternal serum potassium levels remained at normal levels. Delivery of a healthy surviving twin occurred from 2 days to 4 weeks following the selective termination along with delivery of a stillborn abnormal twin.
Selective termination of an abnormal twin may be performed on an outpatient basis in the last weeks of pregnancy. |
| doi_str_mv | 10.1159/000076714 |
| format | Article |
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This is a case series of 4 patients in highly unusual circumstances and treatment. Four healthy patients with desired pregnancies complicated by the presence of an abnormal genetic or developmental diagnosis in 1 twin were treated by selective termination of the abnormal twin using intracardiac injection of potassium chloride.
In all 4 patients, cardiac arrest in the abnormal twin was effected without disturbance of the healthy twin or the mother. Postoperative maternal serum potassium levels remained at normal levels. Delivery of a healthy surviving twin occurred from 2 days to 4 weeks following the selective termination along with delivery of a stillborn abnormal twin.
Selective termination of an abnormal twin may be performed on an outpatient basis in the last weeks of pregnancy.</description><identifier>ISSN: 1015-3837</identifier><identifier>EISSN: 1421-9964</identifier><identifier>DOI: 10.1159/000076714</identifier><identifier>PMID: 15067243</identifier><language>eng</language><publisher>Freiburg: Karger</publisher><subject>Ambulatory Care ; Biological and medical sciences ; Birth control ; Female ; Fetal Diseases - genetics ; Fetus - abnormalities ; Gynecology. Andrology. Obstetrics ; Heart - drug effects ; Hormonal contraception ; Humans ; Injections ; Medical sciences ; Pilot Projects ; Potassium Chloride - administration & dosage ; Pregnancy ; Pregnancy Reduction, Multifetal ; Pregnancy Trimester, Third ; Pregnancy, Multiple ; Twins</subject><ispartof>Fetal diagnosis and therapy, 2004-05, Vol.19 (3), p.292-295</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 S. Karger AG, Basel</rights><rights>Copyright (c) 2004 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15623867$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15067243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HERN, Warren M</creatorcontrib><title>Selective termination for fetal anomaly/ genetic disorder in twin pregnancy at 32+ menstrual weeks: Report of four cases</title><title>Fetal diagnosis and therapy</title><addtitle>Fetal Diagn Ther</addtitle><description>To conduct a pilot study of 4 cases of selective termination of a single abnormal fetus in a dichorionic, diamniotic twin pregnancy advanced to 32 or more menstrual weeks of gestation.
This is a case series of 4 patients in highly unusual circumstances and treatment. Four healthy patients with desired pregnancies complicated by the presence of an abnormal genetic or developmental diagnosis in 1 twin were treated by selective termination of the abnormal twin using intracardiac injection of potassium chloride.
In all 4 patients, cardiac arrest in the abnormal twin was effected without disturbance of the healthy twin or the mother. Postoperative maternal serum potassium levels remained at normal levels. Delivery of a healthy surviving twin occurred from 2 days to 4 weeks following the selective termination along with delivery of a stillborn abnormal twin.
Selective termination of an abnormal twin may be performed on an outpatient basis in the last weeks of pregnancy.</description><subject>Ambulatory Care</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Female</subject><subject>Fetal Diseases - genetics</subject><subject>Fetus - abnormalities</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Heart - drug effects</subject><subject>Hormonal contraception</subject><subject>Humans</subject><subject>Injections</subject><subject>Medical sciences</subject><subject>Pilot Projects</subject><subject>Potassium Chloride - administration & dosage</subject><subject>Pregnancy</subject><subject>Pregnancy Reduction, Multifetal</subject><subject>Pregnancy Trimester, Third</subject><subject>Pregnancy, Multiple</subject><subject>Twins</subject><issn>1015-3837</issn><issn>1421-9964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0Etr3DAQAGARGvLY5JA_EEShuRRn9bBevZUlaQuBQB5nI8vjoNSWXUluuv8-CtlC6Rxm5vDNMAxCZ5RcUirMmpRQUtF6Dx3RmtHKGFl_KD2houKaq0N0nNJzUVpxeYAOqSBSsZofoT_3MIDL_jfgDHH0wWY_BdxPEfeQ7YBtmEY7bNf4CQJk73Dn0xQ7iNgHnF9KmiM8BRvcFtuMOfuMRwgpx6UMvwD8TF_wHcxTzHjqy94lYmcTpBO039shwemurtDj9dXD5nt1c_vtx-brTTUzWeeqVWBkS1grWiJMR1vdWymFASHBttoZ4sCovlNGE9EK6hTTTkmuBe8c8I6v0MX73jlOvxZIuRl9cjAMNsC0pEZRTWqjeYEf_4PP5dhQbmsYY1zqN7VC5zu0tCN0zRz9aOO2-fvQAj7tgE3ODn0sj_HpHycZ11LxV0EBg7M</recordid><startdate>200405</startdate><enddate>200405</enddate><creator>HERN, Warren M</creator><general>Karger</general><general>S. 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Andrology. Obstetrics</topic><topic>Heart - drug effects</topic><topic>Hormonal contraception</topic><topic>Humans</topic><topic>Injections</topic><topic>Medical sciences</topic><topic>Pilot Projects</topic><topic>Potassium Chloride - administration & dosage</topic><topic>Pregnancy</topic><topic>Pregnancy Reduction, Multifetal</topic><topic>Pregnancy Trimester, Third</topic><topic>Pregnancy, Multiple</topic><topic>Twins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HERN, Warren M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Fetal diagnosis and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HERN, Warren M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective termination for fetal anomaly/ genetic disorder in twin pregnancy at 32+ menstrual weeks: Report of four cases</atitle><jtitle>Fetal diagnosis and therapy</jtitle><addtitle>Fetal Diagn Ther</addtitle><date>2004-05</date><risdate>2004</risdate><volume>19</volume><issue>3</issue><spage>292</spage><epage>295</epage><pages>292-295</pages><issn>1015-3837</issn><eissn>1421-9964</eissn><abstract>To conduct a pilot study of 4 cases of selective termination of a single abnormal fetus in a dichorionic, diamniotic twin pregnancy advanced to 32 or more menstrual weeks of gestation.
This is a case series of 4 patients in highly unusual circumstances and treatment. Four healthy patients with desired pregnancies complicated by the presence of an abnormal genetic or developmental diagnosis in 1 twin were treated by selective termination of the abnormal twin using intracardiac injection of potassium chloride.
In all 4 patients, cardiac arrest in the abnormal twin was effected without disturbance of the healthy twin or the mother. Postoperative maternal serum potassium levels remained at normal levels. Delivery of a healthy surviving twin occurred from 2 days to 4 weeks following the selective termination along with delivery of a stillborn abnormal twin.
Selective termination of an abnormal twin may be performed on an outpatient basis in the last weeks of pregnancy.</abstract><cop>Freiburg</cop><cop>Basel</cop><cop>Paris</cop><pub>Karger</pub><pmid>15067243</pmid><doi>10.1159/000076714</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1015-3837 |
| ispartof | Fetal diagnosis and therapy, 2004-05, Vol.19 (3), p.292-295 |
| issn | 1015-3837 1421-9964 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71804983 |
| source | Karger Journal Archive Collection; Karger Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Ambulatory Care Biological and medical sciences Birth control Female Fetal Diseases - genetics Fetus - abnormalities Gynecology. Andrology. Obstetrics Heart - drug effects Hormonal contraception Humans Injections Medical sciences Pilot Projects Potassium Chloride - administration & dosage Pregnancy Pregnancy Reduction, Multifetal Pregnancy Trimester, Third Pregnancy, Multiple Twins |
| title | Selective termination for fetal anomaly/ genetic disorder in twin pregnancy at 32+ menstrual weeks: Report of four cases |
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