Application of capillary electrophoresis to the determination of various benzylpenicillin salts
The application of capillary electrophoresis for separation of benzylpenicillin, procaine, benzathine and clemizole was investigated. Phosphate–borate buffer supplemented with sodium dodecyl sulphate 14.4 g/l and electrophoresis voltage 18 kV seem to provide optimal conditions for micellar electroki...
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| Veröffentlicht in: | Journal of Chromatography A 2004-04, Vol.1032 (1), p.265-272 |
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| container_title | Journal of Chromatography A |
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| creator | Pajchel, Genowefa Michalska, Katarzyna Tyski, Stefan |
| description | The application of capillary electrophoresis for separation of benzylpenicillin, procaine, benzathine and clemizole was investigated. Phosphate–borate buffer supplemented with sodium dodecyl sulphate 14.4
g/l and electrophoresis voltage 18
kV seem to provide optimal conditions for micellar electrokinetic chromatographic assay of penicillin salts. This method is selective and precise. The results obtained from CE method recovery assay (above 98% for all but procaine—97% substances) and from determination of benzylpenicillin by CE compared with HPLC results, confirmed good accuracy. |
| doi_str_mv | 10.1016/j.chroma.2003.11.014 |
| format | Article |
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g/l and electrophoresis voltage 18
kV seem to provide optimal conditions for micellar electrokinetic chromatographic assay of penicillin salts. This method is selective and precise. The results obtained from CE method recovery assay (above 98% for all but procaine—97% substances) and from determination of benzylpenicillin by CE compared with HPLC results, confirmed good accuracy.</description><identifier>ISSN: 0021-9673</identifier><identifier>DOI: 10.1016/j.chroma.2003.11.014</identifier><identifier>PMID: 15065804</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Antibiotics ; Benzathine ; Benzylpenicillin ; Biological and medical sciences ; Clemizole ; Electrophoresis, Capillary - methods ; General pharmacology ; Hydrogen-Ion Concentration ; Medical sciences ; Penicillin G - analysis ; Pharmaceutical analysis ; Pharmacology. Drug treatments ; Procaine ; Reproducibility of Results ; Sensitivity and Specificity</subject><ispartof>Journal of Chromatography A, 2004-04, Vol.1032 (1), p.265-272</ispartof><rights>2003 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-1c648a81ad2c538060cb61271b71d28d57fb1e0d73e7a6e11c2c71b1069d3ab23</citedby><cites>FETCH-LOGICAL-c479t-1c648a81ad2c538060cb61271b71d28d57fb1e0d73e7a6e11c2c71b1069d3ab23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chroma.2003.11.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15554762$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15065804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pajchel, Genowefa</creatorcontrib><creatorcontrib>Michalska, Katarzyna</creatorcontrib><creatorcontrib>Tyski, Stefan</creatorcontrib><title>Application of capillary electrophoresis to the determination of various benzylpenicillin salts</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>The application of capillary electrophoresis for separation of benzylpenicillin, procaine, benzathine and clemizole was investigated. Phosphate–borate buffer supplemented with sodium dodecyl sulphate 14.4
g/l and electrophoresis voltage 18
kV seem to provide optimal conditions for micellar electrokinetic chromatographic assay of penicillin salts. This method is selective and precise. The results obtained from CE method recovery assay (above 98% for all but procaine—97% substances) and from determination of benzylpenicillin by CE compared with HPLC results, confirmed good accuracy.</description><subject>Analysis</subject><subject>Antibiotics</subject><subject>Benzathine</subject><subject>Benzylpenicillin</subject><subject>Biological and medical sciences</subject><subject>Clemizole</subject><subject>Electrophoresis, Capillary - methods</subject><subject>General pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Medical sciences</subject><subject>Penicillin G - analysis</subject><subject>Pharmaceutical analysis</subject><subject>Pharmacology. Drug treatments</subject><subject>Procaine</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFP3DAQhX1oBRT4B1WVS3vbMOMkdvZSCaG2ICFxgbPljCdar5I4tbNI9Nfj7a6gp5588Pee3nxCfEYoEVBdbUvaxDDaUgJUJWIJWH8QZwASV2ulq1PxKaUtAGrQ8kScYgOqaaE-E-Z6ngdPdvFhKkJfkJ39MNj4UvDAtMQwb0Lk5FOxhGLZcOF44Tj66S3xbKMPu1R0PP15GWaePOUGPxXJDku6EB97OyS-PL7n4unnj8eb29X9w6-7m-v7FdV6vayQVN3aFq2T1FQtKKBOodTYaXSydY3uO2RwumJtFSOSpPyJoNausp2szsW3Q-8cw-8dp8WMPhHnUybO64zGfK7EOoP1AaQYUorcmzn6MR9sEMxeptmag0yzl2kQDfyNfTn277qR3XvoaDIDX4-ATWSHPtqJfPqHa5paq_3Q7weOs41nz9Ek8jwROx-zcOOC__-SV2AmmDQ</recordid><startdate>20040402</startdate><enddate>20040402</enddate><creator>Pajchel, Genowefa</creator><creator>Michalska, Katarzyna</creator><creator>Tyski, Stefan</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040402</creationdate><title>Application of capillary electrophoresis to the determination of various benzylpenicillin salts</title><author>Pajchel, Genowefa ; Michalska, Katarzyna ; Tyski, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-1c648a81ad2c538060cb61271b71d28d57fb1e0d73e7a6e11c2c71b1069d3ab23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analysis</topic><topic>Antibiotics</topic><topic>Benzathine</topic><topic>Benzylpenicillin</topic><topic>Biological and medical sciences</topic><topic>Clemizole</topic><topic>Electrophoresis, Capillary - methods</topic><topic>General pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Medical sciences</topic><topic>Penicillin G - analysis</topic><topic>Pharmaceutical analysis</topic><topic>Pharmacology. Drug treatments</topic><topic>Procaine</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pajchel, Genowefa</creatorcontrib><creatorcontrib>Michalska, Katarzyna</creatorcontrib><creatorcontrib>Tyski, Stefan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pajchel, Genowefa</au><au>Michalska, Katarzyna</au><au>Tyski, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of capillary electrophoresis to the determination of various benzylpenicillin salts</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2004-04-02</date><risdate>2004</risdate><volume>1032</volume><issue>1</issue><spage>265</spage><epage>272</epage><pages>265-272</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>The application of capillary electrophoresis for separation of benzylpenicillin, procaine, benzathine and clemizole was investigated. Phosphate–borate buffer supplemented with sodium dodecyl sulphate 14.4
g/l and electrophoresis voltage 18
kV seem to provide optimal conditions for micellar electrokinetic chromatographic assay of penicillin salts. This method is selective and precise. The results obtained from CE method recovery assay (above 98% for all but procaine—97% substances) and from determination of benzylpenicillin by CE compared with HPLC results, confirmed good accuracy.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15065804</pmid><doi>10.1016/j.chroma.2003.11.014</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Analysis Antibiotics Benzathine Benzylpenicillin Biological and medical sciences Clemizole Electrophoresis, Capillary - methods General pharmacology Hydrogen-Ion Concentration Medical sciences Penicillin G - analysis Pharmaceutical analysis Pharmacology. Drug treatments Procaine Reproducibility of Results Sensitivity and Specificity |
| title | Application of capillary electrophoresis to the determination of various benzylpenicillin salts |
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