Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors

Streptococcus pneumoniae is an important human pathogen and the most common cause of community-acquired pneumonia. Both adaptive and innate immune mechanisms provide protection from infection. Innate immunity to S. pneumoniae in mice is mediated by naturally occurring anti-phosphocholine (PC) Abs an...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-06, Vol.168 (12), p.6375-6381
Hauptverfasser:	Mold, Carolyn, Rodic-Polic, Bojana, Du Clos, Terry W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - biosynthesis Antibodies, Bacterial - physiology C-Reactive Protein - administration & dosage C-Reactive Protein - therapeutic use Complement Pathway, Classical - genetics Complement Pathway, Classical - immunology Complement System Proteins - physiology Female Genetic Predisposition to Disease Humans Immunity, Innate - genetics Immunoglobulin M - biosynthesis Immunoglobulin M - physiology Injections, Intravenous Male Mice Mice, Inbred C57BL Mice, Knockout Phosphorylcholine - administration & dosage Phosphorylcholine - immunology Pneumococcal Infections - genetics Pneumococcal Infections - immunology Pneumococcal Infections - prevention & control Polysaccharides, Bacterial - administration & dosage Polysaccharides, Bacterial - immunology Receptors, IgG - deficiency Receptors, IgG - genetics Receptors, IgG - physiology
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