Relationship between p53 pathway and estrogen receptor status in endometrioid-type endometrial cancer

We analyzed the mechanism of estrogen receptor (ER) loss and status of the p53 pathway in 64 cases of endometrial cancer. 26.6% (17 of 64) of endometrial cancers lost ER. Methylation of the ER CpG island was significantly related to ER status (P = 0.0074). However, the methylation site of the ER CpG...

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Veröffentlicht in:	Human pathology 2002-04, Vol.33 (4), p.386-391
Hauptverfasser:	Maeda, Kyoko, Tsuda, Hiroshi, Hashiguchi, Yasunori, Yamamoto, Kumio, Inoue, Takeshi, Ishiko, Osamu, Ogita, Sachio
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma, Endometrioid - chemistry Carcinoma, Endometrioid - genetics Carcinoma, Endometrioid - metabolism DNA Methylation DNA, Neoplasm - analysis endometrial cancer Endometrial Neoplasms - chemistry Endometrial Neoplasms - genetics Endometrial Neoplasms - metabolism estrogen receptor methylation Female Female genital diseases Gene Deletion Gene Expression Gynecology. Andrology. Obstetrics Humans Immunohistochemistry MDM2 Medical sciences Mutation Nuclear Proteins p14ARF p53 p53 pathway Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-mdm2 Receptors, Estrogen - analysis Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Tumor Suppressor Protein p14ARF - genetics Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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