Mycophenolate mofetil prevents autoimmune glomerulonephritis and alterations of intrarenal adrenomedullin in rats
We studied the effects of mycophenolate mofetil, a specific inhibitor of inosine monophosphate dehydrogenase, on the mercuric chloride induced autoimmune glomerulonephritis in Brown Norway rats and also on the renal contents of adrenomedullin. In the rats with autoimmune glomerulonephritis, plasma a...
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| Veröffentlicht in: | European journal of pharmacology 2004-04, Vol.489 (1), p.127-133 |
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| creator | Shi, Yi Yoshihara, Fumiki Nakahama, Hajime Goto, Rieko Sada, Masaharu Kawano, Yuhei Moriyama, Toshiki Yazawa, Koji Ichimaru, Naotsugu Takahara, Shiro Kangawa, Kenji |
| description | We studied the effects of mycophenolate mofetil, a specific inhibitor of inosine monophosphate dehydrogenase, on the mercuric chloride induced autoimmune glomerulonephritis in Brown Norway rats and also on the renal contents of adrenomedullin. In the rats with autoimmune glomerulonephritis, plasma and renal tissue adrenomedullin levels were increased significantly. Coadministration of mycophenolate mofetil resulted in prevention of autoimmune glomerulonephritis and also in maintaining of plasma and renal tissue adrenomedullin levels at control levels. Adrenomedullin mRNA expressions in the renal cortex were also higher in the rats with autoimmune glomerulonephritis. Significant positive correlations were found between renal cortical adrenomedullin levels and urinary Na
+ and
N-acetyl-β-
d-glucosaminidase excretion. A significant negative correlation between renal cortical adrenomedullin levels and creatinine clearance was also found. These results suggest that mycophenolate mofetil suppresses the renal damage in rats with autoimmune glomerulonephritis and renal adrenomedullin may participate in the pathophysiology of autoimmune glomerulonephritis. |
| doi_str_mv | 10.1016/j.ejphar.2004.02.037 |
| format | Article |
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+ and
N-acetyl-β-
d-glucosaminidase excretion. A significant negative correlation between renal cortical adrenomedullin levels and creatinine clearance was also found. These results suggest that mycophenolate mofetil suppresses the renal damage in rats with autoimmune glomerulonephritis and renal adrenomedullin may participate in the pathophysiology of autoimmune glomerulonephritis.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2004.02.037</identifier><identifier>PMID: 15063164</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adrenomedullin ; Animals ; Autoimmune glomerulonephritis ; Biological and medical sciences ; Blotting, Northern ; Brown Norway, rat ; Glomerulonephritis, Membranoproliferative - pathology ; Glomerulonephritis, Membranoproliferative - prevention & control ; Immunosuppressive Agents - pharmacology ; Immunosuppressive Agents - therapeutic use ; IMP Dehydrogenase - antagonists & inhibitors ; Kidney - drug effects ; Kidney - metabolism ; Male ; Medical sciences ; Mercuric chloride ; Mercuric Chloride - pharmacology ; Mycophenolate mofetil ; Mycophenolic Acid - analogs & derivatives ; Mycophenolic Acid - pharmacology ; Mycophenolic Acid - therapeutic use ; Peptides - metabolism ; Pharmacology. Drug treatments ; Proteinuria - drug therapy ; Purines - metabolism ; Radioimmunoassay ; Rats ; Rats, Inbred BN</subject><ispartof>European journal of pharmacology, 2004-04, Vol.489 (1), p.127-133</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-828a3372cd9804239889db5363b55b82535f47f70ccebe3b188b7858604a70c73</citedby><cites>FETCH-LOGICAL-c390t-828a3372cd9804239889db5363b55b82535f47f70ccebe3b188b7858604a70c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2004.02.037$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15627792$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15063164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Yi</creatorcontrib><creatorcontrib>Yoshihara, Fumiki</creatorcontrib><creatorcontrib>Nakahama, Hajime</creatorcontrib><creatorcontrib>Goto, Rieko</creatorcontrib><creatorcontrib>Sada, Masaharu</creatorcontrib><creatorcontrib>Kawano, Yuhei</creatorcontrib><creatorcontrib>Moriyama, Toshiki</creatorcontrib><creatorcontrib>Yazawa, Koji</creatorcontrib><creatorcontrib>Ichimaru, Naotsugu</creatorcontrib><creatorcontrib>Takahara, Shiro</creatorcontrib><creatorcontrib>Kangawa, Kenji</creatorcontrib><title>Mycophenolate mofetil prevents autoimmune glomerulonephritis and alterations of intrarenal adrenomedullin in rats</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>We studied the effects of mycophenolate mofetil, a specific inhibitor of inosine monophosphate dehydrogenase, on the mercuric chloride induced autoimmune glomerulonephritis in Brown Norway rats and also on the renal contents of adrenomedullin. In the rats with autoimmune glomerulonephritis, plasma and renal tissue adrenomedullin levels were increased significantly. Coadministration of mycophenolate mofetil resulted in prevention of autoimmune glomerulonephritis and also in maintaining of plasma and renal tissue adrenomedullin levels at control levels. Adrenomedullin mRNA expressions in the renal cortex were also higher in the rats with autoimmune glomerulonephritis. Significant positive correlations were found between renal cortical adrenomedullin levels and urinary Na
+ and
N-acetyl-β-
d-glucosaminidase excretion. A significant negative correlation between renal cortical adrenomedullin levels and creatinine clearance was also found. These results suggest that mycophenolate mofetil suppresses the renal damage in rats with autoimmune glomerulonephritis and renal adrenomedullin may participate in the pathophysiology of autoimmune glomerulonephritis.</description><subject>Adrenomedullin</subject><subject>Animals</subject><subject>Autoimmune glomerulonephritis</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Brown Norway, rat</subject><subject>Glomerulonephritis, Membranoproliferative - pathology</subject><subject>Glomerulonephritis, Membranoproliferative - prevention & control</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>IMP Dehydrogenase - antagonists & inhibitors</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mercuric chloride</subject><subject>Mercuric Chloride - pharmacology</subject><subject>Mycophenolate mofetil</subject><subject>Mycophenolic Acid - analogs & derivatives</subject><subject>Mycophenolic Acid - pharmacology</subject><subject>Mycophenolic Acid - therapeutic use</subject><subject>Peptides - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Proteinuria - drug therapy</subject><subject>Purines - metabolism</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Rats, Inbred BN</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM-L1TAQx4Mo7nP1PxDpRW-tk6Rtkosgi79gxYueQ5pOfXmkSTdJF_a_N8t7oCdPAzOf7zDzIeQ1hY4CHd-fOjxtR5M6BtB3wDrg4gk5UClUC4Kyp-QAQPuWKaWuyIucTwAwKDY8J1d0gJHTsT-Qu-8PNm5HDNGbgs0aFyzON1vCewwlN2Yv0a3rHrD57eOKafcx4HZMrrg6DXNjfMFkioshN3FpXCjJJAzGN2autWbm3XsX6qSpXH5Jni3GZ3x1qdfk1-dPP2--trc_vny7-XjbWq6gtJJJw7lgdlYSesaVlGqeBj7yaRgmyQY-LL1YBFiLE_KJSjkJOcgRelObgl-Td-e9W4p3O-aiV5ctem8Cxj1rQSVQxVUF-zNoU8w54aK35FaTHjQF_ahan_RZtX5UrYHpqrrG3lz271P98W_o4rYCby-Aydb4JZlgXf6HG5kQilXuw5nDauPeYdLZOgwWZ5fQFj1H9_9L_gB_26Di</recordid><startdate>20040405</startdate><enddate>20040405</enddate><creator>Shi, Yi</creator><creator>Yoshihara, Fumiki</creator><creator>Nakahama, Hajime</creator><creator>Goto, Rieko</creator><creator>Sada, Masaharu</creator><creator>Kawano, Yuhei</creator><creator>Moriyama, Toshiki</creator><creator>Yazawa, Koji</creator><creator>Ichimaru, Naotsugu</creator><creator>Takahara, Shiro</creator><creator>Kangawa, Kenji</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040405</creationdate><title>Mycophenolate mofetil prevents autoimmune glomerulonephritis and alterations of intrarenal adrenomedullin in rats</title><author>Shi, Yi ; Yoshihara, Fumiki ; Nakahama, Hajime ; Goto, Rieko ; Sada, Masaharu ; Kawano, Yuhei ; Moriyama, Toshiki ; Yazawa, Koji ; Ichimaru, Naotsugu ; Takahara, Shiro ; Kangawa, Kenji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-828a3372cd9804239889db5363b55b82535f47f70ccebe3b188b7858604a70c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adrenomedullin</topic><topic>Animals</topic><topic>Autoimmune glomerulonephritis</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Brown Norway, rat</topic><topic>Glomerulonephritis, Membranoproliferative - pathology</topic><topic>Glomerulonephritis, Membranoproliferative - prevention & control</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>IMP Dehydrogenase - antagonists & inhibitors</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mercuric chloride</topic><topic>Mercuric Chloride - pharmacology</topic><topic>Mycophenolate mofetil</topic><topic>Mycophenolic Acid - analogs & derivatives</topic><topic>Mycophenolic Acid - pharmacology</topic><topic>Mycophenolic Acid - therapeutic use</topic><topic>Peptides - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Proteinuria - drug therapy</topic><topic>Purines - metabolism</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Rats, Inbred BN</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Yi</creatorcontrib><creatorcontrib>Yoshihara, Fumiki</creatorcontrib><creatorcontrib>Nakahama, Hajime</creatorcontrib><creatorcontrib>Goto, Rieko</creatorcontrib><creatorcontrib>Sada, Masaharu</creatorcontrib><creatorcontrib>Kawano, Yuhei</creatorcontrib><creatorcontrib>Moriyama, Toshiki</creatorcontrib><creatorcontrib>Yazawa, Koji</creatorcontrib><creatorcontrib>Ichimaru, Naotsugu</creatorcontrib><creatorcontrib>Takahara, Shiro</creatorcontrib><creatorcontrib>Kangawa, Kenji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Yi</au><au>Yoshihara, Fumiki</au><au>Nakahama, Hajime</au><au>Goto, Rieko</au><au>Sada, Masaharu</au><au>Kawano, Yuhei</au><au>Moriyama, Toshiki</au><au>Yazawa, Koji</au><au>Ichimaru, Naotsugu</au><au>Takahara, Shiro</au><au>Kangawa, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mycophenolate mofetil prevents autoimmune glomerulonephritis and alterations of intrarenal adrenomedullin in rats</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2004-04-05</date><risdate>2004</risdate><volume>489</volume><issue>1</issue><spage>127</spage><epage>133</epage><pages>127-133</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>We studied the effects of mycophenolate mofetil, a specific inhibitor of inosine monophosphate dehydrogenase, on the mercuric chloride induced autoimmune glomerulonephritis in Brown Norway rats and also on the renal contents of adrenomedullin. In the rats with autoimmune glomerulonephritis, plasma and renal tissue adrenomedullin levels were increased significantly. Coadministration of mycophenolate mofetil resulted in prevention of autoimmune glomerulonephritis and also in maintaining of plasma and renal tissue adrenomedullin levels at control levels. Adrenomedullin mRNA expressions in the renal cortex were also higher in the rats with autoimmune glomerulonephritis. Significant positive correlations were found between renal cortical adrenomedullin levels and urinary Na
+ and
N-acetyl-β-
d-glucosaminidase excretion. A significant negative correlation between renal cortical adrenomedullin levels and creatinine clearance was also found. These results suggest that mycophenolate mofetil suppresses the renal damage in rats with autoimmune glomerulonephritis and renal adrenomedullin may participate in the pathophysiology of autoimmune glomerulonephritis.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15063164</pmid><doi>10.1016/j.ejphar.2004.02.037</doi><tpages>7</tpages></addata></record> |
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| subjects | Adrenomedullin Animals Autoimmune glomerulonephritis Biological and medical sciences Blotting, Northern Brown Norway, rat Glomerulonephritis, Membranoproliferative - pathology Glomerulonephritis, Membranoproliferative - prevention & control Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use IMP Dehydrogenase - antagonists & inhibitors Kidney - drug effects Kidney - metabolism Male Medical sciences Mercuric chloride Mercuric Chloride - pharmacology Mycophenolate mofetil Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - pharmacology Mycophenolic Acid - therapeutic use Peptides - metabolism Pharmacology. Drug treatments Proteinuria - drug therapy Purines - metabolism Radioimmunoassay Rats Rats, Inbred BN |
| title | Mycophenolate mofetil prevents autoimmune glomerulonephritis and alterations of intrarenal adrenomedullin in rats |
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