Disruption of estrogen receptor beta in mice brain results in pathological alterations resembling Alzheimer disease
AIM: To study the pathological characteristics of the mice with estrogen receptor β (ERβ) disruption in brain.METHODS: Immunohistochemistry method was applied in the study. RESULTS: β-Amyloid peptide(Aβ42) and apolipoprotein E (ApoE) immunoreactive substances were accumulated notably in cortex and l...
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| Veröffentlicht in: | Acta pharmacologica Sinica 2004-04, Vol.25 (4), p.452-457 |
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| container_title | Acta pharmacologica Sinica |
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| creator | Zhang, Qing-hong Huang, Yan-hong Hu, Yu-zhen Wei, Gemg-ze Han, Xue-feng Lu, Shun-yan Zhao, Yu-feng |
| description | AIM: To study the pathological characteristics of the mice with estrogen receptor β (ERβ) disruption in brain.METHODS: Immunohistochemistry method was applied in the study. RESULTS: β-Amyloid peptide(Aβ42) and apolipoprotein E (ApoE) immunoreactive substances were accumulated notably in cortex and limbic structures such as the hippocampus and amygdala in brain, resembling the pathological changes of human Alzheimer disease(AD). Aβ formed cloudy-like deposits in parenchyma of brain, while apoE also deposited along or surrounding the blood vessels. CONCLUSIONS: ERβ is crucial to the development of neural degenerative disease, so modulation of Aβ metabolism via ERβ signal pathway might be beneficial for AD prevention or therapy. |
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RESULTS: β-Amyloid peptide(Aβ42) and apolipoprotein E (ApoE) immunoreactive substances were accumulated notably in cortex and limbic structures such as the hippocampus and amygdala in brain, resembling the pathological changes of human Alzheimer disease(AD). Aβ formed cloudy-like deposits in parenchyma of brain, while apoE also deposited along or surrounding the blood vessels. 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RESULTS: β-Amyloid peptide(Aβ42) and apolipoprotein E (ApoE) immunoreactive substances were accumulated notably in cortex and limbic structures such as the hippocampus and amygdala in brain, resembling the pathological changes of human Alzheimer disease(AD). Aβ formed cloudy-like deposits in parenchyma of brain, while apoE also deposited along or surrounding the blood vessels. CONCLUSIONS: ERβ is crucial to the development of neural degenerative disease, so modulation of Aβ metabolism via ERβ signal pathway might be beneficial for AD prevention or therapy.</abstract><cop>United States</cop><pmid>15066212</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Acta pharmacologica Sinica, 2004-04, Vol.25 (4), p.452-457 |
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| source | MEDLINE; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Alzheimer Disease - metabolism Alzheimer Disease - pathology Amygdala - metabolism Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Animals Apolipoproteins E - metabolism Brain - pathology Cerebral Cortex - metabolism Estrogen Receptor beta Female Hippocampus - metabolism Mice Mice, Inbred C57BL Plaque, Amyloid - pathology Receptors, Estrogen - metabolism 免疫组织化学 动物实验 病理形态学 载脂蛋白E 阿海默滋病 雌激素受体β |
| title | Disruption of estrogen receptor beta in mice brain results in pathological alterations resembling Alzheimer disease |
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