Photostability studies on nicardipine–cyclodextrin complexes by capillary electrophoresis
Nicardipine (NC)–cyclodextrin solid systems were prepared in equimolar ratios and their photostability in aqueous solution under exposure to UV(A)–UV(B) radiations was evaluated. The photodegradation process was monitored by a capillary electrophoresis (CE) method able to provide the enantioresoluti...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2004-04, Vol.35 (2), p.267-275 |
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| creator | Pomponio, R. Gotti, R. Fiori, J. Cavrini, V. Mura, P. Cirri, M. Maestrelli, F. |
| description | Nicardipine (NC)–cyclodextrin solid systems were prepared in equimolar ratios and their photostability in aqueous solution under exposure to UV(A)–UV(B) radiations was evaluated. The photodegradation process was monitored by a capillary electrophoresis (CE) method able to provide the enantioresolution of the
rac-nicardipine. Enantioresolution was achieved using the mixture 3.0% sulfate-β-cyclodextrin (SβCD) and 2.0% heptakis(2,3,6-tri-
O-methyl)-β-cyclodextrin (TMβCD) as chiral selector in 20
mM triethanolammonium phosphate solution (pH 3.0). The photostability studies were carried out on inclusion complexes of
rac-nicardipine with α-cyclodextrin (αCD), β-cyclodextrin (βCD), γ-cyclodextrin (γCD), hydroxypropyl-α-cyclodextrin (HPαCD), hydroxypropyl-β-cyclodextrin (HPβCD), hydroxypropyl-γ-cyclodextrin (HPγCD), (2-hydroxyethyl)-β-cyclodextrin (HEβCD) and methyl-β-cyclodextrin (MβCD). A photoprotective effect was observed by βCD, HPαCD, HEβCD, whereas γCD, MβCD, HPβCD and HPγCD did not affect the nicardipine photostability. Conversely, αCD was found to favour the drug photodegradation.
Evidences for CD
s-mediated stereoselective photodegradation of
rac-nicardipine were observed only for the β-CD complex. In this case, two distinct photodegradation profiles, with two different kinetic constants (
k), were observed for the nicardipine enantiomers. |
| doi_str_mv | 10.1016/S0731-7085(03)00532-6 |
| format | Article |
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rac-nicardipine. Enantioresolution was achieved using the mixture 3.0% sulfate-β-cyclodextrin (SβCD) and 2.0% heptakis(2,3,6-tri-
O-methyl)-β-cyclodextrin (TMβCD) as chiral selector in 20
mM triethanolammonium phosphate solution (pH 3.0). The photostability studies were carried out on inclusion complexes of
rac-nicardipine with α-cyclodextrin (αCD), β-cyclodextrin (βCD), γ-cyclodextrin (γCD), hydroxypropyl-α-cyclodextrin (HPαCD), hydroxypropyl-β-cyclodextrin (HPβCD), hydroxypropyl-γ-cyclodextrin (HPγCD), (2-hydroxyethyl)-β-cyclodextrin (HEβCD) and methyl-β-cyclodextrin (MβCD). A photoprotective effect was observed by βCD, HPαCD, HEβCD, whereas γCD, MβCD, HPβCD and HPγCD did not affect the nicardipine photostability. Conversely, αCD was found to favour the drug photodegradation.
Evidences for CD
s-mediated stereoselective photodegradation of
rac-nicardipine were observed only for the β-CD complex. In this case, two distinct photodegradation profiles, with two different kinetic constants (
k), were observed for the nicardipine enantiomers.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/S0731-7085(03)00532-6</identifier><identifier>PMID: 15063461</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Biotransformation - radiation effects ; Capillary electrophoresis ; Cyclodextrin complexes ; Cyclodextrins - analysis ; Cyclodextrins - metabolism ; Cyclodextrins - radiation effects ; Drug Stability ; Electrophoresis, Capillary - methods ; Enantioresolution ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Medical sciences ; Nicardipine ; Nicardipine - analysis ; Nicardipine - metabolism ; Nicardipine - radiation effects ; Pharmacology. Drug treatments ; Photostability ; Ultraviolet Rays</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2004-04, Vol.35 (2), p.267-275</ispartof><rights>2003 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-a730b5f39315e763e4cc65ac6277bde3fd1217fc6e81b4e1c428eff1ca22d7613</citedby><cites>FETCH-LOGICAL-c391t-a730b5f39315e763e4cc65ac6277bde3fd1217fc6e81b4e1c428eff1ca22d7613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0731-7085(03)00532-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15625593$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15063461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pomponio, R.</creatorcontrib><creatorcontrib>Gotti, R.</creatorcontrib><creatorcontrib>Fiori, J.</creatorcontrib><creatorcontrib>Cavrini, V.</creatorcontrib><creatorcontrib>Mura, P.</creatorcontrib><creatorcontrib>Cirri, M.</creatorcontrib><creatorcontrib>Maestrelli, F.</creatorcontrib><title>Photostability studies on nicardipine–cyclodextrin complexes by capillary electrophoresis</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>Nicardipine (NC)–cyclodextrin solid systems were prepared in equimolar ratios and their photostability in aqueous solution under exposure to UV(A)–UV(B) radiations was evaluated. The photodegradation process was monitored by a capillary electrophoresis (CE) method able to provide the enantioresolution of the
rac-nicardipine. Enantioresolution was achieved using the mixture 3.0% sulfate-β-cyclodextrin (SβCD) and 2.0% heptakis(2,3,6-tri-
O-methyl)-β-cyclodextrin (TMβCD) as chiral selector in 20
mM triethanolammonium phosphate solution (pH 3.0). The photostability studies were carried out on inclusion complexes of
rac-nicardipine with α-cyclodextrin (αCD), β-cyclodextrin (βCD), γ-cyclodextrin (γCD), hydroxypropyl-α-cyclodextrin (HPαCD), hydroxypropyl-β-cyclodextrin (HPβCD), hydroxypropyl-γ-cyclodextrin (HPγCD), (2-hydroxyethyl)-β-cyclodextrin (HEβCD) and methyl-β-cyclodextrin (MβCD). A photoprotective effect was observed by βCD, HPαCD, HEβCD, whereas γCD, MβCD, HPβCD and HPγCD did not affect the nicardipine photostability. Conversely, αCD was found to favour the drug photodegradation.
Evidences for CD
s-mediated stereoselective photodegradation of
rac-nicardipine were observed only for the β-CD complex. In this case, two distinct photodegradation profiles, with two different kinetic constants (
k), were observed for the nicardipine enantiomers.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biotransformation - radiation effects</subject><subject>Capillary electrophoresis</subject><subject>Cyclodextrin complexes</subject><subject>Cyclodextrins - analysis</subject><subject>Cyclodextrins - metabolism</subject><subject>Cyclodextrins - radiation effects</subject><subject>Drug Stability</subject><subject>Electrophoresis, Capillary - methods</subject><subject>Enantioresolution</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Nicardipine</subject><subject>Nicardipine - analysis</subject><subject>Nicardipine - metabolism</subject><subject>Nicardipine - radiation effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Photostability</subject><subject>Ultraviolet Rays</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EFLHDEUwPFQlLrafoSWuSh6mDZvMkl2TqWI2oJgQYVCDyHz8gZTZifTZFbcm9-h37CfxOgu1Zu55PJ7yePP2Afgn4CD-nzJtYBS87k85OKIcymqUr1hM5hrUVaq_rnFZv_JDttN6TfPCpr6LdsByZWoFczYrx83YQppsq3v_bQq0rR0nlIRhmLwaKPzox_o3_1fXGEfHN1N0Q8FhsXY01127apAO_q-t3FVUE84xTDehEjJp3dsu7N9ovebe49dn55cHX8rzy_Ovh9_PS9RNDCVVgveyk40AiRpJahGVNKiqrRuHYnOQQW6Q0VzaGsCrKs5dR2grSqnFYg9drB-d4zhz5LSZBY-IeWdBgrLZDToJh-doVxDjCGlSJ0Zo1_kzQ1w81jVPFU1j8kMF-apqlF57uPmg2W7IPc8tcmYwf4G2IS276Id0KcXTlVSNiK7L2tHOcetp2gSehqQnI85nXHBv7LKA7E0l5Q</recordid><startdate>20040416</startdate><enddate>20040416</enddate><creator>Pomponio, R.</creator><creator>Gotti, R.</creator><creator>Fiori, J.</creator><creator>Cavrini, V.</creator><creator>Mura, P.</creator><creator>Cirri, M.</creator><creator>Maestrelli, F.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040416</creationdate><title>Photostability studies on nicardipine–cyclodextrin complexes by capillary electrophoresis</title><author>Pomponio, R. ; Gotti, R. ; Fiori, J. ; Cavrini, V. ; Mura, P. ; Cirri, M. ; Maestrelli, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-a730b5f39315e763e4cc65ac6277bde3fd1217fc6e81b4e1c428eff1ca22d7613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biotransformation - radiation effects</topic><topic>Capillary electrophoresis</topic><topic>Cyclodextrin complexes</topic><topic>Cyclodextrins - analysis</topic><topic>Cyclodextrins - metabolism</topic><topic>Cyclodextrins - radiation effects</topic><topic>Drug Stability</topic><topic>Electrophoresis, Capillary - methods</topic><topic>Enantioresolution</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Nicardipine</topic><topic>Nicardipine - analysis</topic><topic>Nicardipine - metabolism</topic><topic>Nicardipine - radiation effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Photostability</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pomponio, R.</creatorcontrib><creatorcontrib>Gotti, R.</creatorcontrib><creatorcontrib>Fiori, J.</creatorcontrib><creatorcontrib>Cavrini, V.</creatorcontrib><creatorcontrib>Mura, P.</creatorcontrib><creatorcontrib>Cirri, M.</creatorcontrib><creatorcontrib>Maestrelli, F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pomponio, R.</au><au>Gotti, R.</au><au>Fiori, J.</au><au>Cavrini, V.</au><au>Mura, P.</au><au>Cirri, M.</au><au>Maestrelli, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photostability studies on nicardipine–cyclodextrin complexes by capillary electrophoresis</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2004-04-16</date><risdate>2004</risdate><volume>35</volume><issue>2</issue><spage>267</spage><epage>275</epage><pages>267-275</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>Nicardipine (NC)–cyclodextrin solid systems were prepared in equimolar ratios and their photostability in aqueous solution under exposure to UV(A)–UV(B) radiations was evaluated. The photodegradation process was monitored by a capillary electrophoresis (CE) method able to provide the enantioresolution of the
rac-nicardipine. Enantioresolution was achieved using the mixture 3.0% sulfate-β-cyclodextrin (SβCD) and 2.0% heptakis(2,3,6-tri-
O-methyl)-β-cyclodextrin (TMβCD) as chiral selector in 20
mM triethanolammonium phosphate solution (pH 3.0). The photostability studies were carried out on inclusion complexes of
rac-nicardipine with α-cyclodextrin (αCD), β-cyclodextrin (βCD), γ-cyclodextrin (γCD), hydroxypropyl-α-cyclodextrin (HPαCD), hydroxypropyl-β-cyclodextrin (HPβCD), hydroxypropyl-γ-cyclodextrin (HPγCD), (2-hydroxyethyl)-β-cyclodextrin (HEβCD) and methyl-β-cyclodextrin (MβCD). A photoprotective effect was observed by βCD, HPαCD, HEβCD, whereas γCD, MβCD, HPβCD and HPγCD did not affect the nicardipine photostability. Conversely, αCD was found to favour the drug photodegradation.
Evidences for CD
s-mediated stereoselective photodegradation of
rac-nicardipine were observed only for the β-CD complex. In this case, two distinct photodegradation profiles, with two different kinetic constants (
k), were observed for the nicardipine enantiomers.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15063461</pmid><doi>10.1016/S0731-7085(03)00532-6</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical and biomedical analysis, 2004-04, Vol.35 (2), p.267-275 |
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| subjects | Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Biotransformation - radiation effects Capillary electrophoresis Cyclodextrin complexes Cyclodextrins - analysis Cyclodextrins - metabolism Cyclodextrins - radiation effects Drug Stability Electrophoresis, Capillary - methods Enantioresolution Fundamental and applied biological sciences. Psychology General pharmacology Medical sciences Nicardipine Nicardipine - analysis Nicardipine - metabolism Nicardipine - radiation effects Pharmacology. Drug treatments Photostability Ultraviolet Rays |
| title | Photostability studies on nicardipine–cyclodextrin complexes by capillary electrophoresis |
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