Adenoviral-mediated PTEN transgene expression sensitizes Bcl-2-expressing prostate cancer cells to radiation

Bcl-2 is associated with resistance to radiotherapy in prostate cancer. It was recently demonstrated that transduction of LNCaP prostate cells with the PTEN gene resulted in Bcl-2 downregulation. We hypothesized that forced expression of PTEN in prostate cancer cells would sensitize cells to radiati...

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Veröffentlicht in:	Cancer gene therapy 2004-04, Vol.11 (4), p.273-279
Hauptverfasser:	Rosser, Charles J, Tanaka, Motoyoshi, Pisters, Louis L, Tanaka, Noriyoshi, Levy, Lawrence B, Hoover, David C, Grossman, H Barton, McDonnell, Timothy J, Kuban, Deborah A, Meyn, Raymond E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Bcl-2 protein Biomedical and Life Sciences Biomedicine Care and treatment Cell Cycle - genetics Cell Line, Tumor Combined Modality Therapy Cytomegalovirus Down-Regulation - genetics Flow Cytometry Gene Expression Gene Expression Regulation, Neoplastic Gene Therapy Genetic aspects Genetic Therapy - methods Genetic Vectors - genetics Health aspects Human adenovirus 5 Humans Immunochemistry Male original-article Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Physiological aspects Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - radiotherapy Prostatic Neoplasms - therapy Proto-Oncogene Proteins c-bcl-2 - metabolism PTEN Phosphohydrolase PTEN protein Radiation therapy Radiation Tolerance Radioresistance Radiotherapy Transfection Transgenes Transgenes - genetics Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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