Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells

Background & Aims: The mechanism by which cholelithiasis increases the risk of acute pancreatitis remains obscure. Because bile acids can enter the pancreas either by luminal diffusion or by interstitial leakage during gallstone impaction and pancreatitis is associated with impaired Ca2+ signali...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2002-06, Vol.122 (7), p.1941-1953
Hauptverfasser:	Kim, Joo Young, Kim, Kyung Hwan, Lee, Jin Ah, Namkung, Wan, Sun, An–Qiang, Ananthanarayanan, Meena, Suchy, Frederick J., Shin, Dong Min, Muallem, Shmuel, Lee, Min Goo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - pharmacology Biological and medical sciences Calcium - physiology Calcium-Transporting ATPases - antagonists & inhibitors Carrier Proteins - metabolism Cell Death - drug effects Cell Death - physiology Digestive system Drug Combinations Hydroxysteroid Dehydrogenases Immunologic Techniques In Vitro Techniques Investigative techniques, diagnostic techniques (general aspects) Medical sciences Membrane Glycoproteins Pancreas - cytology Pancreas - drug effects Pancreas - physiology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Rats Reverse Transcriptase Polymerase Chain Reaction Sarcoplasmic Reticulum Calcium-Transporting ATPases Signal Transduction - physiology
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