Manganese supplementation relieves the phenotypic deficits seen in superoxide-dismutase-null Escherichia coli

Escherichia coli, lacking cytoplasmic superoxide dismutases, exhibits a variety of oxygen-dependent phenotypic deficits. Enrichment of the growth medium with Mn(II) relieved those deficits. Extracts of cells grown on Mn(II)-rich medium exhibited superoxide dismutase-like activity that was due partia...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2002-06, Vol.402 (1), p.104-109
Hauptverfasser:	Al-Maghrebi, May, Fridovich, Irwin, Benov, Ludmil
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitase Aconitate Hydratase - metabolism Complementation by Mn(II) Culture Media Edetic Acid - pharmacology Escherichia coli - drug effects Escherichia coli - enzymology Hydrogen Peroxide - pharmacology Manganese - administration & dosage Manganese - pharmacology Manganese in Escherichia coli Molecular Weight Phenotype Protection by Mn(II) Reactive Oxygen Species - metabolism SOD mutants Superoxide Dismutase - genetics Superoxide Dismutase - physiology Superoxide scavenging by manganese
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