Serial Triggering of T Cell Receptors Results in Incremental Accumulation of Signaling Intermediates

Triggering of the T cell receptor (TCR) leads to the production of intracellular intermediates with half-life of a few minutes. Signaling kinetics of events originating from serial TCR triggering and its relation to antigen dose was investigated. In this study we documented incremental accumulation...

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Veröffentlicht in:	The Journal of biological chemistry 2002-06, Vol.277 (24), p.21529-21536
Hauptverfasser:	Borovsky, Zipora, Mishan-Eisenberg, Galit, Yaniv, Einat, Rachmilewitz, Jacob
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens - biosynthesis Antigens, CD - biosynthesis Antigens, Differentiation, T-Lymphocyte - biosynthesis B7-2 Antigen Blotting, Western CD3 Complex - biosynthesis CD4-Positive T-Lymphocytes - metabolism CD69 antigen Cells, Cultured Cytoskeleton - metabolism Dose-Response Relationship, Immunologic Down-Regulation Enzyme-Linked Immunosorbent Assay Humans Interferon-gamma - biosynthesis Interleukin-2 - biosynthesis Jurkat Cells Kinetics Lectins, C-Type Membrane Glycoproteins - biosynthesis Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Receptors, Antigen, T-Cell - metabolism Signal Transduction Time Factors Tyrosine - metabolism
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