Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development

The CDK11(p110) protein kinases are part of large-molecular-weight complexes that also contain RNA polymerase II, transcriptional elongation factors, and general pre-mRNA splicing factors. CDK11(p110) isoforms may therefore couple transcription and pre-mRNA splicing by their effect(s) on certain pro...

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Veröffentlicht in:	Molecular and cellular biology 2004-04, Vol.24 (8), p.3188-3197
Hauptverfasser:	Li, Tongyuan, Inoue, Akira, Lahti, Jill M, Kidd, Vincent J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Blastocyst - cytology Blastocyst - physiology Caspase 3 Caspases - metabolism Cell Division - physiology Cell Size Cyclin-Dependent Kinases - genetics Cyclin-Dependent Kinases - metabolism Fetal Viability Gene Targeting In Situ Nick-End Labeling Isoenzymes - genetics Isoenzymes - metabolism Mice Mice, Knockout Mitosis - physiology
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