The GSK3 β signaling cascade and neurodegenerative disease
Biochemical signaling pathways are known to have a critical role in neuronal development and function. A growing body of evidence is accumulating to suggest that signaling pathways also underlie neurodegeneration and neurodegenerative disease. One pathway with a prominent role in neurodegenerative d...
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| Veröffentlicht in: | Current Opinion in Neurobiology 2002-06, Vol.12 (3), p.275-278 |
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| container_title | Current Opinion in Neurobiology |
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| creator | Kaytor, Michael D Orr, Harry T |
| description | Biochemical signaling pathways are known to have a critical role in neuronal development and function. A growing body of evidence is accumulating to suggest that signaling pathways also underlie neurodegeneration and neurodegenerative disease. One pathway with a prominent role in neurodegenerative disease is the signaling pathway in which the enzyme glycogen synthase kinase 3 (GSK3) is a key component.
In vitro and
in vivo evidence point to a key role for GSK3 in promoting neurodegeneration and in Alzheimer's disease plaque and neurofibrillary tangle formation. How GSK3 acts in this regard is still open to debate, but it may involve both extracellular and nuclear apoptotic activities.
Substantial
in vitro and
in vivo evidence points to a criticalrole for the GSK3beta signaling pathway in neurodegeneration. GSK3beta is a key regulator of both protective and proapoptotic pathways in the central nervous system. |
| doi_str_mv | 10.1016/S0959-4388(02)00320-3 |
| format | Article |
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In vitro and
in vivo evidence point to a key role for GSK3 in promoting neurodegeneration and in Alzheimer's disease plaque and neurofibrillary tangle formation. How GSK3 acts in this regard is still open to debate, but it may involve both extracellular and nuclear apoptotic activities.
Substantial
in vitro and
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In vitro and
in vivo evidence point to a key role for GSK3 in promoting neurodegeneration and in Alzheimer's disease plaque and neurofibrillary tangle formation. How GSK3 acts in this regard is still open to debate, but it may involve both extracellular and nuclear apoptotic activities.
Substantial
in vitro and
in vivo evidence points to a criticalrole for the GSK3beta signaling pathway in neurodegeneration. GSK3beta is a key regulator of both protective and proapoptotic pathways in the central nervous system.</description><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>apoptosis</subject><subject>Calcium-Calmodulin-Dependent Protein Kinases - physiology</subject><subject>Glycogen Synthase Kinase 3</subject><subject>Glycogen Synthase Kinases</subject><subject>Humans</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative Diseases - enzymology</subject><subject>Neurodegenerative Diseases - pathology</subject><subject>neurofibrillary tangles</subject><subject>NFAT</subject><subject>paired helical filaments</subject><subject>Signal Transduction - physiology</subject><subject>signalling</subject><subject>tau</subject><issn>0959-4388</issn><issn>1873-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotn78BGVPoofVyc42yeJBpGgVCx5azyHNztZIu1uTtuDf8of4m0w_0GNPA_M-My88jJ1xuObAxc0Aik6R5qjUJWRXAJhBinuszZXEVCiV7bP2H9JiRyF8AIBAhYesxTPIiwKxzW6H75T0Bi-Y_HwnwY1rM3H1OLEmWFNSYuoyqWnhm5LGVJM3c7ekpHSBTKATdlCZSaDT7Txmb48Pw-5T2n_tPXfv-6nFIpunRvHcSC5BcCUIlKpEB7EDucAKRSXAFjKuKi5zyvJqFDMjrOREkmJe4TG72Pyd-eZzQWGupy5YmkxMTc0i6Pi7kKKQO0GucoxOVAQ7G9D6JgRPlZ55NzX-S3PQK716rVev3GnI9Fqvxnh3vi1YjKZU_l9tfUbgbgNQ9LF05HWwjmpLpfNk57ps3I6KX9w9iDk</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Kaytor, Michael D</creator><creator>Orr, Harry T</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>The GSK3 β signaling cascade and neurodegenerative disease</title><author>Kaytor, Michael D ; Orr, Harry T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-a814a71706186e088f653350463f36f60c97f65f174e24fb335a6c71ee7e36ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>apoptosis</topic><topic>Calcium-Calmodulin-Dependent Protein Kinases - physiology</topic><topic>Glycogen Synthase Kinase 3</topic><topic>Glycogen Synthase Kinases</topic><topic>Humans</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative Diseases - enzymology</topic><topic>Neurodegenerative Diseases - pathology</topic><topic>neurofibrillary tangles</topic><topic>NFAT</topic><topic>paired helical filaments</topic><topic>Signal Transduction - physiology</topic><topic>signalling</topic><topic>tau</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaytor, Michael D</creatorcontrib><creatorcontrib>Orr, Harry T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current Opinion in Neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaytor, Michael D</au><au>Orr, Harry T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The GSK3 β signaling cascade and neurodegenerative disease</atitle><jtitle>Current Opinion in Neurobiology</jtitle><addtitle>Curr Opin Neurobiol</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>12</volume><issue>3</issue><spage>275</spage><epage>278</epage><pages>275-278</pages><issn>0959-4388</issn><eissn>1873-6882</eissn><abstract>Biochemical signaling pathways are known to have a critical role in neuronal development and function. A growing body of evidence is accumulating to suggest that signaling pathways also underlie neurodegeneration and neurodegenerative disease. One pathway with a prominent role in neurodegenerative disease is the signaling pathway in which the enzyme glycogen synthase kinase 3 (GSK3) is a key component.
In vitro and
in vivo evidence point to a key role for GSK3 in promoting neurodegeneration and in Alzheimer's disease plaque and neurofibrillary tangle formation. How GSK3 acts in this regard is still open to debate, but it may involve both extracellular and nuclear apoptotic activities.
Substantial
in vitro and
in vivo evidence points to a criticalrole for the GSK3beta signaling pathway in neurodegeneration. GSK3beta is a key regulator of both protective and proapoptotic pathways in the central nervous system.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>12049933</pmid><doi>10.1016/S0959-4388(02)00320-3</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0959-4388 |
| ispartof | Current Opinion in Neurobiology, 2002-06, Vol.12 (3), p.275-278 |
| issn | 0959-4388 1873-6882 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alzheimer's disease Animals apoptosis Calcium-Calmodulin-Dependent Protein Kinases - physiology Glycogen Synthase Kinase 3 Glycogen Synthase Kinases Humans Neurodegeneration Neurodegenerative Diseases - enzymology Neurodegenerative Diseases - pathology neurofibrillary tangles NFAT paired helical filaments Signal Transduction - physiology signalling tau |
| title | The GSK3 β signaling cascade and neurodegenerative disease |
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