Heterogeneity of stroke pathophysiology and neuroprotective clinical trial design

Tissue substrates for action of neuroprotective agents may be absent in a significant proportion of strokes. Pathophysiological heterogeneity is a possible contributor to negative neuroprotective trials. Stroke subtypes and their individual outcomes in neuroprotective trial control populations were...

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Veröffentlicht in:	Stroke (1970) 2002-06, Vol.33 (6), p.1545-1550
1. Verfasser:	MUIR, Keith W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Clinical Trials as Topic - standards Humans Medical sciences Models, Statistical Neurology Neuroprotective Agents - therapeutic use Patient Selection Reproducibility of Results Research Design - standards Sample Size Stroke - classification Stroke - drug therapy Stroke - physiopathology Treatment Outcome Vascular diseases and vascular malformations of the nervous system
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