Practical Robust Fit of Enzyme Inhibition Data

This chapter describes the practical robust fit of enzyme inhibition data. The analysis of enzyme inhibition data in the context of preclinical drug screening presents unique challenges to the data analyst. Outliers are data points that are affected by gross errors caused by malfunctioning volumetri...

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Veröffentlicht in:	Methods in Enzymology 2004, Vol.383, p.366-381
Hauptverfasser:	Kuzmič, Petr, Hill, Craig, Janc, James W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Dose-Response Relationship, Drug Drug Design Drug Evaluation, Preclinical Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes - drug effects Enzymology Kinetics Least-Squares Analysis Models, Chemical Protein Binding Regression Analysis
Online-Zugang:	Volltext
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