Clinical and pathophysiological characteristics of acute-onset functional dyspepsia
Background & Aims: Functional bowel disorders may follow acute intestinal infection. In animals, postinflammatory dysmotility is associated with nitrergic dysfunction. The aim of this study was to identify and characterize patients with presumed postinfectious dyspepsia (PD) compared with unspec...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2002-06, Vol.122 (7), p.1738-1747 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
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| creator | Tack, Jan Demedts, Ingrid Dehondt, Geert Caenepeel, Philip Fischler, Benjamin Zandecki, Michele Janssens, Jozef |
| description | Background & Aims: Functional bowel disorders may follow acute intestinal infection. In animals, postinflammatory dysmotility is associated with nitrergic dysfunction. The aim of this study was to identify and characterize patients with presumed postinfectious dyspepsia (PD) compared with unspecified-onset dyspepsia (UD). Methods: A total of 400 consecutive dyspeptic patients filled out a questionnaire to assess whether their symptoms were of postinfectious origin. They underwent testing for Helicobacter pylori infection as well as gastric emptying and gastric barostat studies. Pharmacological studies of nitrergic gastric function were performed in controls, in patients with presumed PD, and in patients with UD using sumatriptan, an activator of nitrergic neurons, and amylnitrite, a nitric oxide donor. Results: Presumed PD was present in 17% of the patients and associated with more prevalent early satiety, weight loss, nausea, and vomiting compared with UD. Both groups did not differ in H. pylori infection, gastric emptying, or gastric sensitivity. Impaired accommodation was significantly more prevalent in patients with presumed PD (67% vs. 30%; P < 0.05). Sumatriptan relaxed the stomach in controls and patients with UD but not in patients with presumed PD, whereas amyl nitrite relaxed the stomach in all subjects. Conclusions: A subset of dyspeptic patients has a history suggestive of postinfectious dyspepsia. These patients have a high prevalence of impaired accommodation attributable to a dysfunction at the level of gastric nitrergic neurons.
GASTROENTEROLOGY 2002;122:1738-1747 |
| doi_str_mv | 10.1053/gast.2002.33663 |
| format | Article |
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GASTROENTEROLOGY 2002;122:1738-1747</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1053/gast.2002.33663</identifier><identifier>PMID: 12055579</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Amyl Nitrite - pharmacology ; Biological and medical sciences ; Digestive system ; Dyspepsia - epidemiology ; Dyspepsia - microbiology ; Dyspepsia - physiopathology ; Enzyme Inhibitors - pharmacology ; Female ; Gastrointestinal Motility - drug effects ; Helicobacter Infections - complications ; Helicobacter pylori ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; omega-N-Methylarginine - pharmacology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Reference Values ; Sumatriptan - pharmacology ; Surveys and Questionnaires</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 2002-06, Vol.122 (7), p.1738-1747</ispartof><rights>2002 American Gastroenterological Association</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-d72a88836736b4214036710b0770fe97cefc60d5b20d98988be99f5bb163b1d83</citedby><cites>FETCH-LOGICAL-c354t-d72a88836736b4214036710b0770fe97cefc60d5b20d98988be99f5bb163b1d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/gast.2002.33663$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13713322$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12055579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tack, Jan</creatorcontrib><creatorcontrib>Demedts, Ingrid</creatorcontrib><creatorcontrib>Dehondt, Geert</creatorcontrib><creatorcontrib>Caenepeel, Philip</creatorcontrib><creatorcontrib>Fischler, Benjamin</creatorcontrib><creatorcontrib>Zandecki, Michele</creatorcontrib><creatorcontrib>Janssens, Jozef</creatorcontrib><title>Clinical and pathophysiological characteristics of acute-onset functional dyspepsia</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>Background & Aims: Functional bowel disorders may follow acute intestinal infection. In animals, postinflammatory dysmotility is associated with nitrergic dysfunction. The aim of this study was to identify and characterize patients with presumed postinfectious dyspepsia (PD) compared with unspecified-onset dyspepsia (UD). Methods: A total of 400 consecutive dyspeptic patients filled out a questionnaire to assess whether their symptoms were of postinfectious origin. They underwent testing for Helicobacter pylori infection as well as gastric emptying and gastric barostat studies. Pharmacological studies of nitrergic gastric function were performed in controls, in patients with presumed PD, and in patients with UD using sumatriptan, an activator of nitrergic neurons, and amylnitrite, a nitric oxide donor. Results: Presumed PD was present in 17% of the patients and associated with more prevalent early satiety, weight loss, nausea, and vomiting compared with UD. Both groups did not differ in H. pylori infection, gastric emptying, or gastric sensitivity. Impaired accommodation was significantly more prevalent in patients with presumed PD (67% vs. 30%; P < 0.05). Sumatriptan relaxed the stomach in controls and patients with UD but not in patients with presumed PD, whereas amyl nitrite relaxed the stomach in all subjects. Conclusions: A subset of dyspeptic patients has a history suggestive of postinfectious dyspepsia. These patients have a high prevalence of impaired accommodation attributable to a dysfunction at the level of gastric nitrergic neurons.
GASTROENTEROLOGY 2002;122:1738-1747</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amyl Nitrite - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Dyspepsia - epidemiology</subject><subject>Dyspepsia - microbiology</subject><subject>Dyspepsia - physiopathology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Female</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>omega-N-Methylarginine - pharmacology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Reference Values</subject><subject>Sumatriptan - pharmacology</subject><subject>Surveys and Questionnaires</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M-P1CAUwHFiNO64evZmetFbZx8wFDiaib-STTyoZ0LhdQfTKZVHTea_t7MzyZ48PUI-vJAvY285bDkoeffgqW4FgNhK2XXyGdtwJUwLwMVztllH1yow6oa9IvoNAFYa_pLdcAFKKW037Md-TFMKfmz8FJvZ10OeDydKecwPj9fh4IsPFUuimgI1eWh8WCq2eSKszbBMoaY8rTKeaMaZkn_NXgx-JHxznbfs1-dPP_df2_vvX77tP963QapdbaMW3hgjOy27fif4DtYjhx60hgGtDjiEDqLqBURrrDE9Wjuovued7Hk08pZ9uOydS_6zIFV3TBRwHP2EeSGnubZamDO8u8BQMlHBwc0lHX05OQ7u3NGdO7pzR_fYcX3x7rp66Y8Yn_w13AreX4GnNdNQ_BQSPTmpuZRCrM5eHK4h_iYsjkLCKWBMBUN1Maf_fuIfHtaPkw</recordid><startdate>200206</startdate><enddate>200206</enddate><creator>Tack, Jan</creator><creator>Demedts, Ingrid</creator><creator>Dehondt, Geert</creator><creator>Caenepeel, Philip</creator><creator>Fischler, Benjamin</creator><creator>Zandecki, Michele</creator><creator>Janssens, Jozef</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200206</creationdate><title>Clinical and pathophysiological characteristics of acute-onset functional dyspepsia</title><author>Tack, Jan ; Demedts, Ingrid ; Dehondt, Geert ; Caenepeel, Philip ; Fischler, Benjamin ; Zandecki, Michele ; Janssens, Jozef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-d72a88836736b4214036710b0770fe97cefc60d5b20d98988be99f5bb163b1d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amyl Nitrite - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Dyspepsia - epidemiology</topic><topic>Dyspepsia - microbiology</topic><topic>Dyspepsia - physiopathology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Female</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>omega-N-Methylarginine - pharmacology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Reference Values</topic><topic>Sumatriptan - pharmacology</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tack, Jan</creatorcontrib><creatorcontrib>Demedts, Ingrid</creatorcontrib><creatorcontrib>Dehondt, Geert</creatorcontrib><creatorcontrib>Caenepeel, Philip</creatorcontrib><creatorcontrib>Fischler, Benjamin</creatorcontrib><creatorcontrib>Zandecki, Michele</creatorcontrib><creatorcontrib>Janssens, Jozef</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tack, Jan</au><au>Demedts, Ingrid</au><au>Dehondt, Geert</au><au>Caenepeel, Philip</au><au>Fischler, Benjamin</au><au>Zandecki, Michele</au><au>Janssens, Jozef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and pathophysiological characteristics of acute-onset functional dyspepsia</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>2002-06</date><risdate>2002</risdate><volume>122</volume><issue>7</issue><spage>1738</spage><epage>1747</epage><pages>1738-1747</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>Background & Aims: Functional bowel disorders may follow acute intestinal infection. In animals, postinflammatory dysmotility is associated with nitrergic dysfunction. The aim of this study was to identify and characterize patients with presumed postinfectious dyspepsia (PD) compared with unspecified-onset dyspepsia (UD). Methods: A total of 400 consecutive dyspeptic patients filled out a questionnaire to assess whether their symptoms were of postinfectious origin. They underwent testing for Helicobacter pylori infection as well as gastric emptying and gastric barostat studies. Pharmacological studies of nitrergic gastric function were performed in controls, in patients with presumed PD, and in patients with UD using sumatriptan, an activator of nitrergic neurons, and amylnitrite, a nitric oxide donor. Results: Presumed PD was present in 17% of the patients and associated with more prevalent early satiety, weight loss, nausea, and vomiting compared with UD. Both groups did not differ in H. pylori infection, gastric emptying, or gastric sensitivity. Impaired accommodation was significantly more prevalent in patients with presumed PD (67% vs. 30%; P < 0.05). Sumatriptan relaxed the stomach in controls and patients with UD but not in patients with presumed PD, whereas amyl nitrite relaxed the stomach in all subjects. Conclusions: A subset of dyspeptic patients has a history suggestive of postinfectious dyspepsia. These patients have a high prevalence of impaired accommodation attributable to a dysfunction at the level of gastric nitrergic neurons.
GASTROENTEROLOGY 2002;122:1738-1747</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12055579</pmid><doi>10.1053/gast.2002.33663</doi><tpages>10</tpages></addata></record> |
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| subjects | Adolescent Adult Age of Onset Aged Aged, 80 and over Amyl Nitrite - pharmacology Biological and medical sciences Digestive system Dyspepsia - epidemiology Dyspepsia - microbiology Dyspepsia - physiopathology Enzyme Inhibitors - pharmacology Female Gastrointestinal Motility - drug effects Helicobacter Infections - complications Helicobacter pylori Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged omega-N-Methylarginine - pharmacology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Reference Values Sumatriptan - pharmacology Surveys and Questionnaires |
| title | Clinical and pathophysiological characteristics of acute-onset functional dyspepsia |
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